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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Uchl1
ubiquitin carboxy-terminal hydrolase L1
MGI:103149
45 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Uchl1gad-2J/Uchl1gad-2J
B6.Cg-Uchl1gad-2J/GrsrJ 		abnormal locomotor coordination J:161692
ataxia J:161692
neurodegeneration J:161692
paralysis J:161692
premature death J:161692
weight loss J:161692
Uchl1gad-J/Uchl1gad-J
involves: BALB/c * C57BL/6 		impaired coordination J:142436
premature death J:142436
weight loss J:142436
Uchl1gad/Uchl1gad
involves: CBA/Nga * RFM/Nga 		abnormal dorsal root ganglion morphology J:71819
abnormal gait J:71819
abnormal hindlimb morphology J:30954
abnormal medulla oblongata morphology J:30954
abnormal spinal cord dorsal column morphology J:30954
abnormal stationary movement J:30954
ataxia J:30954, J:71819
axon degeneration J:30954
axonal dystrophy J:71819
normal cardiovascular system phenotype J:30954
decreased body weight J:71819
normal digestive/alimentary phenotype J:30954
normal hematopoietic system phenotype J:30954
normal liver/biliary system phenotype J:30954
paralysis J:71819
premature death J:30954, J:71819
normal renal/urinary system phenotype J:30954
normal respiratory system phenotype J:30954
tremors J:30954
weight loss J:30954
Uchl1gad/Uchl1gad
Not Specified 		axon degeneration J:28526
motor neuron degeneration J:28526
Uchl1tm1b(EUCOMM)Hmgu/Uchl1+
C57BL/6N-Uchl1tm1b(EUCOMM)Hmgu/H 		abnormal spine curvature J:211773
hyperactivity J:211773
increased blood urea nitrogen level J:211773
increased circulating alkaline phosphatase level J:211773
increased mean platelet volume J:211773
increased startle reflex J:211773
Uchl1tm1Dgen/Uchl1tm1Dgen
B6.129P2-Uchl1tm1Dgen/Mmnc 		abnormal endplate potential J:156538
abnormal gait J:156538
abnormal miniature endplate potential J:156538
abnormal neuromuscular synapse morphology J:156538
abnormal PNS synaptic transmission J:156538
abnormal synaptic plasticity J:156538
axon degeneration J:156538
decreased neurotransmitter release J:156538
decreased paired-pulse facilitation J:156538
forelimb paralysis J:156538
hindlimb paralysis J:156538
increased synaptic depression J:156538
kyphosis J:156538
limb grasping J:156538
motor neuron degeneration J:156538
premature death J:156538
Uchl1tm1Dgen/Uchl1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		decreased grip strength J:207278
impaired coordination J:101679, J:207278
increased coping response J:101679
increased thermal nociceptive threshold J:101679
weight loss J:207278
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory