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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc12a1
solute carrier family 12, member 1
MGI:103150
62 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc12a1tm1Haca/Slc12a1tm1Haca
involves: 129S/SvEv * C57BL/6 * FVB/N 		abnormal mineral level J:135710
abnormal tubuloglomerular feedback response J:135710
decreased circulating renin level J:135710
decreased urine osmolality J:135710
Slc12a1tm1Tkh/Slc12a1tm1Tkh
involves: 129S6/SvEvTac 		abnormal blood homeostasis J:62224
abnormal fluid regulation J:62224
abnormal kidney morphology J:62224
abnormal kidney physiology J:62224
abnormal renal tubule morphology J:62224
decreased circulating glucose level J:62224
decreased skin turgor J:62224
hydronephrosis J:62224
increased circulating chloride level J:62224
increased circulating creatinine level J:62224
increased circulating sodium level J:62224
increased circulating total protein level J:62224
increased hematocrit J:62224
increased renin activity J:62224
increased urine calcium level J:62224
kidney failure J:62224
metabolic acidosis J:62224
nephrocalcinosis J:62224
polyuria J:62224
postnatal growth retardation J:62224
postnatal lethality, complete penetrance J:62224
Slc12a1tm2Haca/Slc12a1tm2Haca
involves: 129S/SvEv * FVB/N 		abnormal circulating magnesium level J:148062
abnormal renal reabsorption J:148062
abnormal renal water reabsorption J:148062
decreased tubuloglomerular feedback response J:148062
decreased urine osmolality J:148062
increased circulating renin level J:148062
increased tubuloglomerular feedback response J:148062
Slc12a1urehr3/Slc12a1urehr3
C3HeB/FeJ-Slc12a1urehr3 		abnormal kidney morphology J:121470
abnormal renal tubule morphology J:121470
decreased circulating chloride level J:121470
decreased circulating glucose level J:121470
decreased urine creatinine level J:121470
decreased urine sodium level J:121470
hydronephrosis J:121470
increased blood urea nitrogen level J:121470
increased circulating creatinine level J:121470
kidney papillary atrophy J:121470
nephrocalcinosis J:121470
polydipsia J:121470
polyuria J:121470
Slc12a1urehr3/Slc12a1urehr3
involves: C3HeB/FeJ 		abnormal blood homeostasis J:159994
abnormal bone structure J:159994
abnormal urine homeostasis J:159994
abnormal urine urea nitrogen level J:159994
alkalosis J:159994
normal behavior/neurological phenotype J:159994
decreased bone mineral density J:159994
decreased circulating chloride level J:159994
decreased circulating creatinine level J:159994
decreased circulating renin level J:159994
decreased mean systemic arterial blood pressure J:159994
decreased systemic arterial systolic blood pressure J:159994
decreased urine osmolality J:159994
decreased urine uric acid level J:159994
hydronephrosis J:159994
increased blood urea nitrogen level J:159994
increased circulating alkaline phosphatase level J:159994
increased circulating atrial natriuretic factor J:159994
increased circulating calcium level J:159994
increased circulating magnesium level J:159994
increased creatinine clearance J:159994
increased urine calcium level J:159994
increased urine creatinine level J:159994
increased urine magnesium level J:159994
increased urine osmolality J:159994
increased urine potassium level J:159994
increased urine prostaglandin level J:159994
increased urine sodium level J:159994
kidney papillary atrophy J:159994
nephrocalcinosis J:159994
polyuria J:159994
pyelitis J:159994
pyelonephritis J:159994
normal reproductive system phenotype J:159994
weight loss J:159994
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory