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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cish
cytokine inducible SH2-containing protein
MGI:103159
22 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cishtm1.1Cdon/Cishtm1.1Cdon
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:204829
Cishtm1.1Cdon/Cishtm1.1Cdon
Tg(Cd4-cre)1Cwi/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal T-helper 2 cell differentiation J:204829
increased eosinophil cell number J:204829
increased interleukin-4 secretion J:204829
increased interleukin-5 secretion J:204829
increased interleukin-10 secretion J:204829
increased interleukin-13 secretion J:204829
increased susceptibility to type I hypersensitivity reaction J:204829
Cishtm1.1Khk/Cishtm1.1Khk
Tg(Ins1-EGFP)1Hara/0
Tg(Pdx1-cre)89.1Dam/0
involves: C57BL/6 * CBA * CD-1 		normal endocrine/exocrine gland phenotype J:203844
normal homeostasis/metabolism phenotype J:203844
Cishtm1.2Cdon/Cishtm1.2Cdon
B6.129S6(Cg)-Cishtm1.2Cdon 		abnormal CD4-positive T cell differentiation J:204829
abnormal immune system morphology J:204829
abnormal immune system physiology J:204829
abnormal respiratory mucosa goblet cell morphology J:204829
abnormal T-helper 2 cell differentiation J:204829
normal immune system phenotype J:204829
increased eosinophil cell number J:204829
increased interleukin-4 secretion J:204829
increased interleukin-5 secretion J:204829
increased interleukin-9 secretion J:204829
increased interleukin-13 secretion J:204829
increased lymphocyte cell number J:204829
increased susceptibility to type I hypersensitivity reaction J:204829
increased T cell proliferation J:204829
lung inflammation J:204829
lymph node hyperplasia J:204829
pulmonary fibrosis J:204829
spleen hyperplasia J:204829
thymus hyperplasia J:204829
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory