Gfi1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gfi1
growth factor independent 1 transcription repressor
MGI:103170

68 phenotypes from 10 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gfi1^Gen/Gfi1⁺ C57BL/6J-Gfi1^Gen	abnormal myelopoiesis	J:182679
	abnormal NK cell differentiation	J:182679
	abnormal NK cell physiology	J:182679
	absent neutrophils	J:182679
	decreased NK cell degranulation	J:182679
	normal immune system phenotype	J:182679
Gfi1^tm1.1Wep/Gfi1^tm1.1Wep B6.129-Gfi1^tm1.1Wep	arrested T cell differentiation	J:117105
	decreased B cell number	J:117105
	decreased body size	J:117105
	small thymus	J:117105
	thymus hypoplasia	J:117105
Gfi1^tm1Sho/Gfi1^tm1Sho involves: 129S1/Sv * C57BL/6J	abnormal cochlear hair cell development	J:80025
	abnormal cochlear hair cell morphology	J:80025
	abnormal cochlear OHC efferent innervation pattern	J:80025
	abnormal outer hair cell stereociliary bundle morphology	J:80025
	abnormal vestibular hair cell morphology	J:80025
	absent startle reflex	J:80025
	ataxia	J:80025
	circling	J:80025
	cochlear ganglion degeneration	J:80025
	cochlear hair cell degeneration	J:80025
	cochlear inner hair cell degeneration	J:80025
	cochlear outer hair cell degeneration	J:80025
	deafness	J:80025
	decreased body size	J:80025
	decreased cochlear outer hair cell number	J:80025
	degeneration of organ of Corti supporting cells	J:80025
	head tilt	J:80025
	hyperactivity	J:80025
	increased vestibular hair cell number	J:80025
	organ of Corti degeneration	J:80025
	postnatal growth retardation	J:80025
	premature death	J:80025
Gfi1^tm1Tmo/Gfi1^tm1Tmo involves: 129S1/Sv * 129X1/SvJ	decreased B cell number	J:192927
	decreased granulocyte number	J:192927
	decreased neutrophil cell number	J:192927
	decreased thymocyte number	J:192927
	increased hematopoietic stem cell number	J:192927
	increased monocyte cell number	J:192927
Gfi1^tm1Tmo/Gfi1^tm1Tmo involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cochlear inner hair cell morphology	J:92833
	abnormal cochlear outer hair cell morphology	J:92833
	abnormal cytokine secretion	J:75143
	abnormal granulocyte differentiation	J:75143
	abnormal inner hair cell stereociliary bundle morphology	J:92833
	abnormal monocyte differentiation	J:75143
	abnormal myelopoiesis	J:75143
	abnormal outer hair cell stereociliary bundle morphology	J:92833
	abnormal T cell differentiation	J:75143
	abnormal vestibular system physiology	J:92833
	cochlear outer hair cell degeneration	J:92833
	deafness	J:92833
	decreased B cell number	J:75143
	decreased body weight	J:75143
	decreased granulocyte number	J:75143
	decreased lymphocyte cell number	J:75143
	decreased neutrophil cell number	J:75143
	decreased T cell number	J:75143
	decreased thymocyte number	J:75143
	increased interleukin-1 beta secretion	J:75143
	increased interleukin-10 secretion	J:75143
	increased susceptibility to endotoxin shock	J:75143
	increased tumor necrosis factor secretion	J:75143
	premature death	J:75143
	short inner hair cell stereocilia	J:92833
Gfi1^tm1Wep/Gfi1^tm1Wep B6.129-Gfi1^tm1Wep	abnormal definitive hematopoiesis	J:117105
	abnormal T cell proliferation	J:117105
	decreased body size	J:117105
Gfi1^tm1Wep/Gfi1^tm1Wep Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal T cell proliferation	J:117105
	abnormal T cell subpopulation ratio	J:117105
	abnormal T-helper 2 physiology	J:117105
Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/Gfi1⁺ B6.Cg-Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/Gan	no abnormal phenotype detected	J:297267
Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/Gfi1^{tm2.1(GFP/cre/ERT2)Gan} B6.Cg-Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/Gan	normal hearing/vestibular/ear phenotype	J:297267
	no abnormal phenotype detected	J:297267
Gfi1^tm2Tmo/Gfi1^tm2Tmo involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal T cell differentiation	J:93337
	decreased neutrophil cell number	J:93337
	decreased thymocyte number	J:93337
Gfi1^{tm3(Gfib1)Tmo}/Gfi1^{tm3(Gfib1)Tmo} involves: 129S1/Sv * 129X1/SvJ	abnormal cochlear inner hair cell morphology	J:116870
	abnormal cochlear outer hair cell morphology	J:116870
	abnormal monocyte morphology	J:116870
	absent outer hair cell stereocilia	J:116870
	absent pinna reflex	J:116870
	cochlear outer hair cell degeneration	J:116870
	deafness	J:116870
	decreased granulocyte number	J:116870
	head bobbing	J:116870
	normal hematopoietic system phenotype	J:116870
	increased or absent threshold for auditory brainstem response	J:116870
Gfi1^tm4Tmo/Gfi1^tm4Tmo involves: 129S1/Sv * 129X1/SvJ	abnormal cochlear inner hair cell morphology	J:116870
	abnormal cochlear outer hair cell morphology	J:116870
	abnormal lymphopoiesis	J:116870
	abnormal monocyte morphology	J:116870
	abnormal neutrophil morphology	J:116870
	abnormal T cell differentiation	J:116870
	abnormal vestibular system physiology	J:116870
	absent outer hair cell stereocilia	J:116870
	absent pinna reflex	J:116870
	cochlear outer hair cell degeneration	J:116870
	deafness	J:116870
	decreased double-negative T cell number	J:116870
	decreased lymphocyte cell number	J:116870
	decreased neutrophil cell number	J:116870
	decreased thymocyte number	J:116870
Gfi1^{tm6.1(GFI1)Tmo}/Gfi1^{tm6.1(GFI1)Tmo} involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal hematopoietic system phenotype	J:192927

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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