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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mpz
myelin protein zero
MGI:103177
56 phenotypes from 17 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mpzem1(IMPC)Tcp/Mpzem1(IMPC)Tcp
C57BL/6NCrl-Mpzem1(IMPC)Tcp/Tcp 		abnormal gait J:211773
abnormal lung morphology J:211773
abnormal skin morphology J:211773
decreased fasting circulating glucose level J:211773
decreased grip strength J:211773
decreased locomotor activity J:211773
decreased prepulse inhibition J:211773
increased mean platelet volume J:211773
tremors J:211773
Mpzm1Anu/?
involves: BALB/c * C57BL/6 * DBA/2 		abnormal gait J:196547
limb grasping J:196547
tremors J:196547
Mpzm1Btlr/Mpzm1Btlr
C57BL/6J-Mpzm1Btlr 		abnormal limb posture J:265100
ataxia J:265100
limb grasping J:265100
Mpztm1.1Wra/Mpz+
FVB.129S2-Mpztm1.1Wra 		abnormal axon radial sorting J:267903
dysmyelination J:267903
impaired coordination J:267903
Mpztm1.1Wra/Mpztm1.1Wra
FVB.129S2-Mpztm1.1Wra 		dysmyelination J:267903
Mpztm1Msch/Mpz+
B6.129S7-Mpztm1Msch 		abnormal myelin sheath morphology J:59319
abnormal myelination J:59319
abnormal nerve conduction J:59319
abnormal nervous system physiology J:59319
abnormal neuron morphology J:59319
autoimmune response J:59319
increased Schwann cell number J:59319
Mpztm1Msch/Mpz+
involves: 129S7/SvEvBrd 		abnormal myelination J:42838
abnormal nerve conduction J:42838
demyelination J:133028
dysmyelination J:267903
increased macrophage cell number J:133028
neuron degeneration J:133028
Mpztm1Msch/Mpz+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cytokine secretion J:82432
abnormal gait J:82432
abnormal macrophage chemotaxis J:67581
abnormal T-helper 1 physiology J:82432
increased monocyte cell number J:82432
paralysis J:82432
Mpztm1Msch/Mpz+
Tg(Mpz)88.1Mfel/0
FVB.Cg-Mpztm1Msch Tg(Mpz)88.1Mfel 		decreased nerve conduction velocity J:77658
Mpztm1Msch/Mpz+
Tg(Mpz)88.4Mfel/0
FVB.Cg-Mpztm1Msch Tg(Mpz)88.4Mfel 		decreased myelin sheath thickness J:77658
tomacula J:77658
Mpztm1Msch/Mpz+
Tg(Mpz*S63X)31Mes/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal action potential J:105751
axon degeneration J:105751
decreased myelin sheath thickness J:105751
decreased nerve conduction velocity J:105751
demyelination J:105751
impaired coordination J:105751
Mpztm1Msch/Mpz+
Tg(Mpz*S63C)33Mes/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal myelin sheath morphology J:105751
demyelination J:105751
dysmyelination J:105751
Mpztm1Msch/Mpztm1Msch
involves: 129S7/SvEvBrd 		abnormal gait J:3234
abnormal locomotor coordination J:3234
abnormal myelination J:42838
abnormal nerve conduction J:42838
abnormal Schwann cell morphology J:3234
impaired swimming J:3234
limb grasping J:3234
tremors J:3234
weakness J:3234
Mpztm1Msch/Mpztm1Msch
Tg(Mpz)80.4Wra/0
involves: 129S7/SvEvBrd * FVB/N 		normal nervous system phenotype J:78758
Mpztm1Msch/Mpztm1Msch
Tg(Mpz)88.4Mfel/0
FVB.Cg-Mpztm1Msch Tg(Mpz)88.4Mfel 		abnormal myelin sheath morphology J:77658
decreased myelin sheath thickness J:77658
dysmyelination J:77658
tomacula J:77658
Mpztm1Msch/Mpztm1Msch
Tg(Mpz*S63C)33Mes/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal myelination J:105751
Mpztm1Msch/Mpztm1Msch
Tg(Mpz*S63X)31Mes/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal myelination J:105751
Mpztm3.1Wra/Mpz+
FVB.129S2(Cg)-Mpztm3.1Wra 		abnormal action potential J:241742
abnormal myelin sheath morphology J:241742
abnormal Schwann cell morphology J:241742
abnormal sciatic nerve morphology J:241742
decreased myelin sheath thickness J:241742
decreased nerve conduction velocity J:241742
impaired coordination J:241742
increased Schwann cell proliferation J:241742
Mpztm3.1Wra/Mpztm3.1Wra
FVB.129S2(Cg)-Mpztm1.1Wra 		abnormal action potential J:241742
abnormal myelin sheath morphology J:241742
abnormal Schwann cell morphology J:241742
abnormal sciatic nerve morphology J:241742
ataxia J:241742
decreased myelin sheath thickness J:241742
decreased nerve conduction velocity J:241742
dysmyelination J:241742
impaired coordination J:241742
increased endoplasmic reticulum stress J:241742
increased Schwann cell proliferation J:241742
tremors J:241742
Mpzttrr/Mpzttrr
B6.Cg-Mpzttrr/GrsrJ 		abnormal gait J:149880
demyelination J:149880
female infertility J:149880
hindlimb paralysis J:149880
infertility J:149880
male infertility J:149880
premature death J:149880
tremors J:149880
Tg(Mpz)80.2Wra/0
involves: FVB/N 		abnormal axon radial sorting J:78758
abnormal gait J:78758
abnormal myelin sheath morphology J:78758
abnormal nervous system development J:78758
decreased body weight J:78758
decreased grip strength J:78758
decreased nerve conduction velocity J:78758
dysmyelination J:78758
increased collagen level J:78758
infertility J:78758
muscular atrophy J:78758
premature death J:78758
tremors J:78758
Tg(Mpz)80.3Wra/0
involves: FVB/N 		normal behavior/neurological phenotype J:78758
dysmyelination J:78758
normal mortality/aging J:78758
Tg(Mpz)80.3Wra/Tg(Mpz)80.3Wra
involves: FVB/N 		dysmyelination J:78758
tremors J:78758
Tg(Mpz)80.4Wra/0
involves: FVB/N 		decreased nerve conduction velocity J:78758
dysmyelination J:78758
premature death J:78758
tremors J:78758
Tg(Mpz)88.1Mfel/0
FVB/N-Tg(Mpz)88.1Mfel 		abnormal myelin sheath morphology J:77658
axon degeneration J:77658
decreased nerve conduction velocity J:77658
demyelination J:77658
dysmyelination J:77658
muscle weakness J:77658
muscular atrophy J:77658
tomacula J:77658
tremors J:77658
Tg(Mpz)88.2Mfel/0
FVB/N-Tg(Mpz)88.2Mfel 		abnormal behavior J:77658
abnormal myelin sheath morphology J:77658
axon degeneration J:77658
demyelination J:77658
dysmyelination J:77658
muscle weakness J:77658
muscular atrophy J:77658
tomacula J:77658
tremors J:77658
Tg(Mpz)88.4Mfel/0
FVB/N-Tg(Mpz)88.4Mfel 		abnormal myelin sheath morphology J:77658
decreased nerve conduction velocity J:77658
dysmyelination J:77658
muscle weakness J:77658
tomacula J:77658
tremors J:77658
Tg(Mpz*S63C)32Mes/0
involves: FVB/N 		abnormal nervous system physiology J:105751
ataxia J:105751
demyelination J:105751
dysmyelination J:105751
muscular atrophy J:105751
tremors J:105751
weakness J:105751
Tg(Mpz*S63C)33Mes/0
involves: FVB/N 		abnormal myelin sheath morphology J:105751
abnormal nervous system physiology J:105751
ataxia J:105751
demyelination J:105751
dysmyelination J:105751
muscular atrophy J:105751
tremors J:105751
weakness J:105751
Tg(Mpz*S63X)30Mes/0
involves: FVB/N 		abnormal nervous system physiology J:105751
ataxia J:105751
demyelination J:105751
dysmyelination J:105751
muscular atrophy J:105751
tremors J:105751
weakness J:105751
Tg(Mpz*S63X)31Mes/0
involves: FVB/N 		abnormal nervous system physiology J:105751
ataxia J:105751
demyelination J:105751
dysmyelination J:105751
muscular atrophy J:105751
tremors J:105751
weakness J:105751
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory