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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfib
nuclear factor I/B
MGI:103188
43 phenotypes from 3 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfibtm1Hsch/Nfib+
involves: 129S1/Sv * C57BL/6 		abnormal lung development J:75698
abnormal lung saccule morphology J:75698
increased wet-to-dry lung weight ratio J:75698
pulmonary hypoplasia J:75698
thick lung-associated mesenchyme J:75698
Nfibtm1Hsch/Nfibtm1Hsch
involves: 129S1/Sv * C57BL/6 		abnormal lung development J:75698
abnormal lung morphology J:75698
abnormal pulmonary alveolus epithelial cell morphology J:75698
abnormal respiration J:75698
absent lung saccules J:75698
atelectasis J:75698
cyanosis J:75698
eyelids open at birth J:75698
failure of eyelid fusion J:75698
impaired branching involved in terminal bronchiole morphogenesis J:75698
increased wet-to-dry lung weight ratio J:75698
neonatal lethality, complete penetrance J:75698
pulmonary hypoplasia J:75698
respiratory distress J:75698
respiratory failure J:75698
Nfibtm1Rmg/Nfib+
involves: 129P2/OlaHsd * Black Swiss 		abnormal corpus callosum morphology J:96006
abnormal glial cell morphology J:96006
abnormal lung development J:96006
neonatal lethality, incomplete penetrance J:96006
small lung saccule J:96006
Nfibtm1Rmg/Nfib+
involves: 129P2/OlaHsd * C57BL/6 		abnormal corpus callosum morphology J:96006
abnormal glial cell morphology J:96006
abnormal lung development J:96006
postnatal lethality, incomplete penetrance J:96006
small lung saccule J:96006
Nfibtm1Rmg/Nfib+
involves: 129P2/OlaHsd * FVB/N 		abnormal lung development J:96006
normal mortality/aging J:96006
small lung saccule J:96006
Nfibtm1Rmg/Nfibtm1Rmg
involves: 129P2/OlaHsd 		abnormal lung development J:173651
abnormal respiratory system physiology J:173651
Nfibtm1Rmg/Nfibtm1Rmg
involves: 129P2/OlaHsd * Black Swiss 		abnormal glial cell morphology J:96006
abnormal hippocampal fimbria morphology J:96006
abnormal hippocampus CA3 region morphology J:96006
abnormal hippocampus development J:96006
abnormal lung development J:96006
abnormal lung morphology J:96006
abnormal pons morphology J:96006
absent cerebellar foliation J:96006
absent corpus callosum J:96006
absent dentate gyrus J:96006
absent hippocampus CA3 region J:96006
absent lung saccules J:96006
enlarged brain ventricles J:96006
neonatal lethality, complete penetrance J:96006
Nfibtm1Rmg/Nfibtm1Rmg
involves: 129P2/OlaHsd * C57BL/6 		abnormal cerebellar granule cell morphology J:121963
abnormal craniofacial development J:177282
abnormal glial cell morphology J:96006
abnormal hippocampal fimbria morphology J:96006
abnormal hippocampus CA3 region morphology J:96006
abnormal hippocampus development J:96006
abnormal lung development J:96006
abnormal lung morphology J:96006
abnormal major salivary gland morphology J:218202
abnormal pons morphology J:96006
abnormal submandibular gland development J:218202
absent cerebellar foliation J:96006
absent corpus callosum J:96006
absent dentate gyrus J:96006
absent hippocampus CA3 region J:96006
absent lung saccules J:96006
decreased fetal size J:177282
decreased submandibular gland size J:218202
enlarged brain ventricles J:96006
submandibular gland hypoplasia J:218202
Nfibtm1Rmg/Nfibtm1Rmg
involves: 129P2/OlaHsd * FVB/N 		abnormal lung development J:96006
abnormal lung morphology J:96006
absent lung saccules J:96006
Nfibtm2Rmg/Nfibtm2Rmg
involves: 129S4/SvJae * C57BL/6 		normal respiratory system phenotype J:173651
Nfibtm2Rmg/Nfibtm2Rmg
Twist2tm1(cre)Dor/Twist2+
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal lung development J:173651
abnormal lung morphology J:173651
abnormal lung saccule morphology J:173651
abnormal respiratory system physiology J:173651
enlarged lung J:173651
perinatal lethality, complete penetrance J:173651
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory