Cdc25a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdc25a
cell division cycle 25A
MGI:103198

21 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdc25a^{Gt(OST186277)Lex}/Cdc25a⁺ involves: 129S5/SvEvBrd * C57BL/6J	abnormal trabecular bone morphology	J:103485
Cdc25a^{Gt(OST186277)Lex}/Cdc25a^{Gt(OST186277)Lex} involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Cdc25a^m1Rfp/Cdc25a^m1Rfp multiple strains	abnormal cell cycle checkpoint function	J:80142
	abnormal enzyme/coenzyme activity	J:80142
	abnormal erythropoiesis	J:80142
	increased cell proliferation	J:80142
Cdc25a^tm1.1Hpw/Cdc25a^tm1.1Hpw involves: 129X1/SvJ * C57BL/6	abnormal inner cell mass morphology	J:145768
	embryonic growth retardation	J:145768
	embryonic lethality between implantation and somite formation, complete penetrance	J:145768
	increased apoptosis	J:145768
Cdc25a^tm1Dvb/Cdc25a^tm1Dvb involves: 129	abnormal centrosome morphology	J:144548
	abnormal mitosis	J:144548
	aneuploidy	J:144548
	increased cellular sensitivity to gamma-irradiation	J:144548
	increased incidence of tumors by ionizing radiation induction	J:144548
Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	normal digestive/alimentary phenotype	J:145768
Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Tg(Vil1-cre/ERT2)23Syr/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal large intestine morphology	J:169457
	abnormal small intestine morphology	J:169457
	normal growth/size/body region phenotype	J:169457
Cdc25a^tm1Hpw/Cdc25a^tm1Hpw involves: 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:145768
Cdc25a^tm1Kiyo/Cdc25a^tm1Kiyo involves: 129/Sv * C57BL/6	abnormal blastocyst hatching	J:123144
Cdc25a^tm1Kiyo/Cdc25a^tm1Kiyo involves: 129/Sv * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:123144

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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