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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Vhl
von Hippel-Lindau tumor suppressor
MGI:103223
133 phenotypes from 9 alleles in 24 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hprt1tm1(Pck1-cre)Vhh/Y
Vhltm1Jae/Vhltm1Jae
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 		abnormal kidney morphology J:106705
abnormal kidney vasculature morphology J:106705
abnormal vasodilation J:97652
hepatic steatosis J:97652
increased hemoglobin content J:97652
increased hepatic hemangioma incidence J:97652
increased vascular endothelial cell number J:97652
kidney cyst J:106705
kidney inflammation J:106705
polycythemia J:97652
Tg(Fabp1-cre)1Jig/0
Vhltm1Jae/Vhltm1Jae
involves: 129S4/SvJae * BALB/c * FVB/N 		abnormal digestive system physiology J:93476
decreased susceptibility to induced colitis J:93476
Vhltm1.1Jae/Vhl+
involves: 129S4/SvJae * BALB/c 		abnormal blood vessel morphology J:67505
hepatic steatosis J:67505
increased hepatic hemangioma incidence J:67505
Vhltm1.1Jae/Vhltm1.1Jae
involves: 129S4/SvJae * BALB/c 		embryonic lethality during organogenesis, complete penetrance J:67505
Vhltm1.1Lss/Vhl+
involves: A/J 		abnormal liver morphology J:85513
Vhltm1.1Lss/Vhl+
involves: BALB/c 		increased hepatic hemangioma incidence J:85513
Vhltm1.1Whkr/Vhltm1.1Whkr
involves: 129S4/SvJae * C57BL/6 		abnormal intracellular organelle physiology J:198361
normal liver/biliary system phenotype J:198361
Vhltm1.1Wkr/Vhl+
involves: 129S4/SvJae * C57BL/6 		abnormal blood vessel morphology J:157369
increased adenocarcinoma incidence J:157369
increased incidence of tumors by chemical induction J:157369
kidney cortex cyst J:157369
normal liver/biliary system phenotype J:157369
preneoplasia J:157369
Vhltm1.1Wkr/Vhltm1.1Wkr
involves: 129S4/SvJae * C57BL/6 		embryonic lethality during organogenesis, incomplete penetrance J:157369
Vhltm1Bjg/Vhltm1Bjg
Not Specified 		abnormal limb bud morphology J:48254
abnormal pharyngeal arch morphology J:48254
embryonic growth retardation J:48254
embryonic lethality during organogenesis, complete penetrance J:48254
Vhltm1Jae/Vhltm1Jae
involves: 129S4/SvJae 		decreased cell proliferation J:160941
Vhltm1Jae/Vhltm1Jae
involves: 129S4/SvJae * BALB/c 		no abnormal phenotype detected J:67505
Vhltm1Jae/Vhltm1Jae
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJae 		increased inflammatory response J:107682
Vhltm1Jae/Vhltm1Jae
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA 		abnormal blood vessel morphology J:67505
abnormal liver morphology J:67505
abnormal vasodilation J:97652
decreased body weight J:67505
enlarged liver J:67505
hepatic steatosis J:67505, J:97652
increased vascular endothelial cell number J:97652
polycythemia J:67505
premature death J:67505
Vhltm1Jae/Vhltm1Jae
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * DBA 		abnormal blood vessel morphology J:144666
abnormal hepatocyte morphology J:144666
abnormal liver morphology J:144666
decreased body size J:144666
hepatic steatosis J:144666
increased hematocrit J:144666
increased hepatocyte proliferation J:144666
increased liver weight J:144666
premature death J:144666
reddish skin J:144666
reticulocytosis J:144666
Vhltm1Jae/Vhltm1Jae
Tg(Cdh16-cre)91Igr/0
involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR 		hydronephrosis J:137073
Vhltm1Jae/Vhltm1Jae
Tg(Cdh16-cre)91Igr/0
involves: 129S4/SvJae * ICR 		abnormal epididymis morphology J:137442
Vhltm1Jae/Vhltm1Jae
Tg(KRT14-cre)1Ipc/0
involves: 129S4/SvJae * C57BL/6 * SJL 		alopecia J:144666
decreased body size J:144666
dilated vasculature J:144666
epidermal hyperplasia J:144666
increased keratinocyte proliferation J:144666
increased vascular permeability J:144666
reddish skin J:144666
Vhltm1Jae/Vhltm1Jae
Tg(Myh6-cre)2182Mds/0
involves: 129S4/SvJae * FVB/N 		abnormal heart left ventricle morphology J:179490
cardiomyopathy J:179490
decreased heart rate J:193425
decreased heart ventricle muscle contractility J:179490
decreased mitochondrial number J:179490
increased angiogenesis J:179490
increased heart weight J:179490
irregular heartbeat J:193425
postnatal lethality, complete penetrance J:193425
premature death J:179490
prolonged QRS complex duration J:193425
prolonged QT interval J:193425
Vhltm1Jae/Vhltm1Jae
Tg(NPHS2-cre)295Lbh/?
involves: 129S4/SvJae * C57BL/6 * SJL 		abnormal renal glomerulus basement membrane morphology J:162099
albuminuria J:162099
cachexia J:162099
decreased podocyte number J:162099
dilated glomerular capillary J:162099
dilated kidney collecting duct J:162099
dilated renal tubule J:162099
edema J:162099
expanded mesangial matrix J:162099
glomerular crescent J:162099
increased blood urea nitrogen level J:162099
increased mesangial cell number J:162099
increased renal glomerulus basement membrane thickness J:162099
kidney failure J:162099
podocyte foot process effacement J:162099
premature death J:162099
renal cast J:162099
renal glomerulus fibrosis J:162099
renal interstitial fibrosis J:162099
normal renal/urinary system phenotype J:162099
Vhltm1Jae/Vhltm1Jae
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S4/SvJae 		abnormal retina vasculature morphology J:217533
Vhltm1Jae/Vhltm1Jae
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S4/SvJae * CD-1 		abnormal angiogenesis J:186085
abnormal blood cell morphology/development J:186085
abnormal foot pad morphology J:186085
decreased body size J:186085
decreased bone marrow cell number J:186085
decreased lymphocyte cell number J:186085
enlarged spleen J:186085
extramedullary hematopoiesis J:186085
increased bone trabecula number J:186085
increased circulating erythropoietin level J:186085
increased erythrocyte cell number J:186085
increased erythroid progenitor cell number J:186085
increased hematocrit J:186085
increased hematopoietic stem cell number J:186085
increased osteoblast cell number J:186085
increased trabecular bone mass J:186085
increased trabecular bone volume J:186085
polycythemia J:186085
Vhltm1Lss/Vhltm1.1Lss
involves: 129X1/SvJ * C57BL/6 		increased hepatic hemangioma incidence J:85513
oligozoospermia J:85513
Vhltm1Lss/Vhltm1.1Lss
Tg(ACTB-cre)1Tes/0
involves: 129X1/SvJ * C3H * C57BL/6 		abnormal angiogenesis J:85513
abnormal blood vessel morphology J:85513
abnormal liver morphology J:85513
decreased Sertoli cell number J:85513
increased hepatic hemangioma incidence J:85513
male infertility J:85513
multinucleated giant male germ cells J:85513
oligozoospermia J:85513
premature death J:85513
seminiferous tubule degeneration J:85513
small testis J:85513
Vhltm1Lss/Vhltm1.1Lss
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal blood vessel morphology J:110518
abnormal placenta labyrinth morphology J:110518
abnormal placental labyrinth vasculature morphology J:110518
abnormal vitelline vasculature morphology J:110518
decreased blood urea nitrogen level J:155367
decreased circulating creatinine level J:155367
decreased embryo size J:110518
decreased renal tubule apoptosis J:155367
decreased susceptibility to kidney reperfusion injury J:155367
embryo tissue necrosis J:110518
focal hepatic necrosis J:110518
hemorrhage J:110518
lethality throughout fetal growth and development, complete penetrance J:110518
pallor J:110518
thin placenta labyrinth J:110518
Vhltm1Lss/Vhltm1Lss
Tg(Gcg-cre)1Slib/0
either: (involves: 129X1/SvJ * A/J) or (involves: 129X1/SvJ * C57BL/6) 		normal endocrine/exocrine gland phenotype J:148174
normal mortality/aging J:148174
Vhltm1Lss/Vhltm1Lss
Tg(Ins2-cre)25Mgn/0
either: (involves: 129X1/SvJ * C57BL/6 * DBA) or (involves: 129X1/SvJ * A/J * C57BL/6 * DBA) 		normal endocrine/exocrine gland phenotype J:148174
normal mortality/aging J:148174
Vhltm1Lss/Vhltm1Lss
Tg(Pdx1-cre)89.1Dam/0
either: (involves: 129X1/SvJ * A/J * C57BL/6 * CBA) or (involves: 129X1/SvJ * BALB/c * C57BL/6 * CBA) 		postnatal lethality, incomplete penetrance J:148174
Vhltm1Lss/Vhltm1Lss
Tg(Pdx1-cre)89.1Dam/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal exocrine pancreas morphology J:148174
abnormal pancreatic islet morphology J:148174
increased pancreas adenoma incidence J:148174
pancreas cyst J:148174
postnatal lethality, incomplete penetrance J:148174
Vhltm1Mcs/Vhltm1Mcs
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal common myeloid progenitor cell morphology J:130780
abnormal erythropoiesis J:130780
abnormal liver morphology J:130780
abnormal spleen morphology J:130780
decreased spleen white pulp amount J:130780
normal hematopoietic system phenotype J:130780
increased angiogenesis J:130780
increased erythrocyte cell number J:130780
increased erythroid progenitor cell number J:130780
increased hematocrit J:130780
increased hemoglobin content J:130780
increased leukocyte cell number J:130780
increased megakaryocyte cell number J:130780
increased spleen red pulp amount J:130780
increased spleen weight J:130780
normal neoplasm J:130780
polycythemia J:130780
prenatal lethality, incomplete penetrance J:130780
pulmonary hypertension J:130780
Vhltm1Wml/Vhl+
involves: 129S4/SvJae * C57BL/6 		increased incidence of tumors by chemical induction J:88492
Vhltm1Wml/Vhltm1Wml
involves: 129S4/SvJae * C57BL/6 		abnormal placenta development J:42486
abnormal placental labyrinth vasculature morphology J:42486
abnormal trophoblast layer morphology J:42486
embryonic lethality during organogenesis, complete penetrance J:42486
placenta hemorrhage J:42486
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory