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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
MGI:103234
22 phenotypes from 13 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Herc2Gt(AR0530)Wtsi/Herc2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal autophagy J:252045
abnormal lysosome morphology J:252045
abnormal Purkinje cell dendrite morphology J:252045
impaired coordination J:252045
normal nervous system phenotype J:252045
Purkinje cell axonal dystrophy J:252045
Purkinje cell degeneration J:252045
Herc2Gt(AR0530)Wtsi/Herc2Gt(AR0530)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality, complete penetrance J:252045
Herc2J/Herc2J
BALB/cJ-Herc2J 		abnormal spermatid morphology J:58776
decreased body size J:58776
decreased corpora lutea number J:58776
decreased male germ cell number J:58776
male infertility J:58776
oligozoospermia J:58776
reduced female fertility J:58776
tremors J:58776
Herc2jdf2-1R/Herc2jdf2-1R
Not Specified 		abnormal behavior J:100221
decreased body size J:100221
female infertility J:100221
male infertility J:100221
Herc2jdf2-2R/Herc2jdf2-2R
Not Specified 		abnormal behavior J:100221
decreased body size J:100221
female infertility J:100221
male infertility J:100221
Herc2jdf2-3R/Herc2jdf2-3R
Not Specified 		abnormal behavior J:100221
decreased body size J:100221
female infertility J:100221
male infertility J:100221
Herc2jdf2-4R/Herc2jdf2-4R
Not Specified 		prenatal lethality, complete penetrance J:100221
Herc2jdf2-5R/Herc2jdf2-5R
Not Specified 		prenatal lethality, complete penetrance J:100221
Herc2jdf2-6R/Herc2jdf2-6R
Not Specified 		prenatal lethality, complete penetrance J:100221
Herc2jdf2-7R/Herc2jdf2-7R
Not Specified 		prenatal lethality, complete penetrance J:100221
Herc2jdf2-8R/Herc2jdf2-8R
Not Specified 		abnormal behavior J:100221
decreased body size J:100221
female infertility J:100221
male infertility J:100221
Herc2jdf2-9R/Herc2jdf2-9R
Not Specified 		decreased body size J:100221
postnatal lethality, incomplete penetrance J:100221
Herc2jdf2-10R/Herc2jdf2-10R
Not Specified 		decreased body size J:100221
postnatal lethality, incomplete penetrance J:100221
Herc2mpc178H/Herc2mpc178H
involves: BALB/c * C3H/HeH * C57BL/6J 		decreased body fat mass J:234901
decreased lean body mass J:234901
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory