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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Yap1
yes-associated protein 1
MGI:103262
92 phenotypes from 12 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Raxtm1.1(cre/ERT2)Sbls/Rax+
Yap1tm1Hmc/Yap1tm1Hmc
involves: 129S6/SvEvTac * C57BL/6NCrl 		abnormal glial cell physiology J:304126
abnormal retina morphology J:304126
retina gliosis J:304126
Tg(MYH7-Yap1*S112A)#Eno/?
involves: C3H * C57BL/6 		abnormal myocardial trabeculae morphology J:189577
abnormal myocardium layer morphology J:189577
thick myocardium J:189577
Yap1M1Btlr/Yap1M1Btlr
C57BL/6J-Yap1M1Btlr 		increased susceptibility to induced colitis J:267549
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal bile duct development J:162628
abnormal bile duct morphology J:162628
abnormal hepatocyte morphology J:162628
enlarged liver J:162628
increased circulating alanine transaminase level J:162628
increased circulating bilirubin level J:162628
increased hepatocyte apoptosis J:162628
increased hepatocyte proliferation J:162628
liver cirrhosis J:162628
liver fibrosis J:162628
macrovesicular hepatic steatosis J:162628
pale liver J:162628
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6J * SJL 		abnormal enterocyte proliferation J:165471
normal digestive/alimentary phenotype J:165471
increased enterocyte apoptosis J:165471
increased susceptibility to induced colitis J:165471
increased susceptibility to weight loss J:165471
increased susceptibility to xenobiotic induced morbidity/mortality J:165471
Yap1tm1.1Eno/Yap1tm1.1Eno
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S/SvEv 		abnormal myocardium layer morphology J:189577
decreased heart rate J:189577
embryonic lethality during organogenesis, complete penetrance J:189577
thin myocardium J:189577
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N 		abnormal atrial thrombosis J:200670
abnormal cardiovascular system physiology J:200670
cardiac fibrosis J:200670
decreased cardiac muscle contractility J:200670
dilated cardiomyopathy J:200670
dilated heart ventricle J:200670
increased myocardial infarct size J:200670
lethargy J:200670
premature death J:200670
respiratory distress J:200670
thin ventricular wall J:200670
Yap1tm1.1Fcam/Yap1tm1.1Fcam
Tg(KRT14-cre)1Amc/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal epidermal layer morphology J:171057
abnormal epidermal stem cell morphology J:171057
abnormal epidermis stratum basale morphology J:171057
abnormal epidermis stratum corneum morphology J:171057
abnormal skin condition J:171057
decreased cell proliferation J:171057
impaired skin barrier function J:171057
increased cell proliferation J:171057
thin epidermis J:171057
thin epidermis stratum basale J:171057
thin skin J:171057
Yap1tm1.1Fcam/Yap1tm2.1Fcam
Tg(KRT14-cre)1Amc/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal epidermal layer morphology J:171057
abnormal skin morphology J:171057
decreased cell proliferation J:171057
neonatal lethality, complete penetrance J:171057
thin skin J:171057
Yap1tm1.1Hmc/Yap1+
involves: 129S6/SvEvTac * BALB/c * C57BL/6 * C57BL/6NCrl 		abnormal electroretinogram waveform feature J:304126
abnormal glial cell physiology J:304126
abnormal retina morphology J:304126
abnormal retina progenitor cell morphology J:304126
abnormal ribbon synapse morphology J:304126
cataract J:304126
decreased b-wave amplitude J:304126
decreased retina cone cell number J:304126
retina cone cell degeneration J:304126
retina gliosis J:304126
Yap1tm1.2Dupa/Yap1tm1.2Dupa
Not Specified 		preweaning lethality, complete penetrance J:162628
Yap1tm1b(KOMP)Mbp/Yap1tm1b(KOMP)Mbp
C57BL/6N-Yap1tm1b(KOMP)Mbp/MbpMmucd 		preweaning lethality, complete penetrance J:211773
Yap1tm1Hmc/Yap1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl 		abnormal kidney cortex morphology J:195266
abnormal kidney development J:195266
abnormal kidney medulla morphology J:195266
abnormal kidney papilla morphology J:195266
abnormal loop of Henle morphology J:195266
abnormal metanephros morphology J:195266
abnormal nephrogenic zone morphology J:195266
abnormal proximal convoluted tubule morphology J:195266
abnormal renal glomerulus morphology J:195266
abnormal renal tubule morphology J:195266
anuria J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
impaired branching involved in ureteric bud morphogenesis J:195266
podocyte foot process effacement J:195266
postnatal lethality, complete penetrance J:195266
renal hypoplasia J:195266
Yap1tm1Smil/Yap1tm1Smil
either: (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * C57BL/6J * CD-1) 		abnormal blood vessel morphology J:102253
abnormal dorsal-ventral axis patterning J:102253
abnormal embryo development J:102253
abnormal embryonic tissue morphology J:102253
abnormal nervous system morphology J:102253
abnormal posterior primitive streak morphology J:102253
abnormal rostral-caudal body axis extension J:102253
abnormal ventral body wall morphology J:102253
abnormal visceral yolk sac morphology J:102253
absent visceral yolk sac blood islands J:102253
decreased embryo size J:102253
disorganized yolk sac vascular plexus J:102253
embryonic lethality during organogenesis, complete penetrance J:102253
embryonic-extraembryonic boundary constriction J:102253
excessive folding of visceral yolk sac J:102253
incomplete embryo turning J:102253
Yap1tm2.1Dupa/Yap1tm2.1Dupa
Not Specified 		increased incidence of tumors by chemical induction J:223215
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory