Yap1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Yap1
yes-associated protein 1
MGI:103262

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Col1a1^{tm1(tetO-Yap1)Lrsn}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * C57BL/6	premature death	J:185310
Kras^tm4Tyj/Kras^tm4Tyj Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	increased hepatocellular carcinoma incidence	J:162628
Lats1^tm1Noj/Lats1^tm1Noj Lats2^tm1.1Dupa/Lats2^tm1.1Dupa Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Dupa/Yap1^tm1.1Dupa involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas	abnormal bile duct epithelium morphology	J:223215
	enlarged liver	J:223215
Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Yap1^{tm1c(KOMP)Mbp}/Yap1^{tm1c(KOMP)Mbp} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA	abnormal cholangiocyte morphology	J:228499
	increased liver weight	J:228499
	liver fibrosis	J:228499
Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA	enlarged liver	J:162628
	normal liver/biliary system phenotype	J:162628
	normal neoplasm	J:162628
Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA	normal liver/biliary system phenotype	J:162628
	normal neoplasm	J:162628
Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm2.1Dupa/Yap1^tm2.1Dupa involves: 129P2/OlaHsd	abnormal bile duct epithelium morphology	J:223215
	abnormal bile duct physiology	J:223215
	enlarged liver	J:223215
	increased hamartoma incidence	J:223215
Sav1^tm1.1Dupa/Sav1^tm1.1Dupa Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Tg(Vil1-cre)997Gum/0 involves: 129P2/OlaHsd * C57BL/6J * SJL	normal digestive/alimentary phenotype	J:165471
Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk Yap1^tm1Smil/Yap1⁺ either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	abnormal developmental patterning	J:131426
	abnormal embryo turning	J:131426
Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺ Yap1^tm1Smil/Yap1⁺ either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	abnormal allantois morphology	J:131426
	abnormal embryo development	J:131426
	abnormal embryonic tissue morphology	J:131426
Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0 involves: 129S4/SvJae * C57BL/6N * CBA * SJL	normal cardiovascular system phenotype	J:273437
Wwtr1^tm1.1Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	increased cardiomyocyte apoptosis	J:200670
	myocardium hypoplasia	J:200670
	postnatal lethality, complete penetrance	J:200670
	thin myocardium	J:200670
Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	abnormal atrial thrombosis	J:200670
	dilated cardiomyopathy	J:200670
	premature death	J:200670
Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	abnormal heart morphology	J:200670
	neonatal lethality, complete penetrance	J:200670
Wwtr1^tm1Hku/Wwtr1^tm1Hku Yap1^tm1Smil/Yap1^tm1Smil involves: 129S/SvEv	embryonic lethality before implantation, complete penetrance	J:147050
Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl	abnormal kidney development	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	kidney cyst	J:195266

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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