Atp6v0a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atp6v0a1
ATPase, H+ transporting, lysosomal V0 subunit A1
MGI:103286

27 phenotypes from 4 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atp6v0a1^em1Hisa/Atp6v0a1^em1Hisa involves: ICR	embryonic lethality between implantation and placentation, complete penetrance	J:305201
Atp6v0a1^em2Hisa/Atp6v0a1^em2Hisa involves: ICR	abnormal cerebellar molecular layer	J:305201
	abnormal cerebral cortex pyramidal cell morphology	J:305201
	abnormal dentate gyrus morphology	J:305201
	abnormal excitatory synapse morphology	J:305201
	abnormal hippocampus CA3 region morphology	J:305201
	abnormal lysosome morphology	J:305201
	abnormal miniature excitatory postsynaptic currents	J:305201
	abnormal miniature inhibitory postsynaptic currents	J:305201
	abnormal synaptic vesicle morphology	J:305201
	absent gastric milk in neonates	J:305201
	ataxia	J:305201
	cleft palate	J:305201
	decreased body weight	J:305201
	decreased brain size	J:305201
	decreased cerebral cortex pyramidal cell number	J:305201
	decreased CNS synapse formation	J:305201
	impaired autophagy	J:305201
	impaired righting response	J:305201
	increased neuron apoptosis	J:305201
	postnatal lethality, complete penetrance	J:305201
Atp6v0a1^em3Hisa/Atp6v0a1^em3Hisa involves: ICR	embryonic lethality between implantation and placentation, complete penetrance	J:305201
Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Atp6v0a1⁺ C57BL/6N-Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Tcp	decreased total body fat amount	J:211773
	increased bone mineral content	J:211773
	increased circulating potassium level	J:211773
Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Atp6v0a1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Atp6v0a1^{tm1b(EUCOMM)Hmgu}/Tcp	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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