Rela Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
MGI:103290

68 phenotypes from 10 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rela^tm1.1Gho/Rela^tm1.1Gho involves: 129S6/SvEvTac * C57BL/6	abnormal eye development	J:134684
	abnormal limb morphology	J:134684
	anophthalmia	J:134684
	embryonic lethality, incomplete penetrance	J:134684
	microphthalmia	J:134684
Rela^tm1.2Gho/Rela^tm1.2Gho involves: 129S6/SvEvTac * C57BL/6	increased hepatocyte apoptosis	J:134684
	lethality throughout fetal growth and development, complete penetrance	J:134684
Rela^tm1Asba/Rela^tm1Asba Tg(Vil1-cre)997Gum/0 involves: 129 * C57BL/6J * SJL	abnormal intestinal epithelium morphology	J:131977
	abnormal small intestinal villus morphology	J:131977
	abnormal small intestine crypts of Lieberkuhn morphology	J:131977
	abnormal small intestine morphology	J:131977
	decreased survivor rate	J:131977
	diarrhea	J:131977
	impaired intestine regeneration	J:131977
	increased susceptibility to induced colitis	J:131977
	increased susceptibility to xenobiotic induced morbidity/mortality	J:131977
	megacolon	J:131977
	premature death	J:131977
	slow postnatal weight gain	J:131977
Rela^tm1Bal/Rela^tm1Bal B6.129S4-Rela^tm1Bal	increased hepatocyte apoptosis	J:111325
	internal hemorrhage	J:111325
	lethality throughout fetal growth and development, complete penetrance	J:111325
Rela^tm1Bal/Rela^tm1Bal B6;129S4-Rela^tm1Bal/J	normal homeostasis/metabolism phenotype	J:91366
Rela^tm1Bal/Rela^tm1Bal involves: 129S4/SvJae	abnormal cell death	J:28390
	abnormal neuron physiology	J:119844
	abnormal trigeminal nerve morphology	J:119844
	decreased marginal zone B cell number	J:65246
	normal immune system phenotype	J:113514
	increased neuron apoptosis	J:119844
Rela^tm1Bal/Rela^tm1Bal involves: 129S4/SvJae * C57BL/6J	increased hepatocyte apoptosis	J:28390
	internal hemorrhage	J:28390
	lethality throughout fetal growth and development, complete penetrance	J:28390
	liver degeneration	J:28390
Rela^tm1Mpa/Rela^tm1Mpa Tg(Alb1-cre)7Gsc/0 involves: FVB/N	increased susceptibility to endotoxin shock	J:137861
Rela^tm1Rsch/Rela^tm1Rsch Ptf1a^tm1(cre)Hnak/? involves: C57BL/6	abnormal interleukin level	J:122194
	abnormal response/metabolism to endogenous compounds	J:122194
	abnormal tumor necrosis factor level	J:122194
	increased susceptibility to xenobiotic induced morbidity/mortality	J:122194
	lung inflammation	J:122194
	pancreas inflammation	J:122194
Rela^tm1Rsch/Rela^tm1Rsch Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal gamma-delta T cell morphology	J:169863
Rela^tm1Rsch/Rela^tm1Rsch Tg(Lck-cre)I57Jxm/0 involves: ICR	abnormal gamma-delta T cell morphology	J:169863
	decreased interleukin-17 secretion	J:169863
	normal immune system phenotype	J:169863
	increased susceptibility to bacterial infection	J:169863
Rela^tm1Ukl/Rela^tm1Ukl B6.129S1-Rela^tm1Ukl/J	no abnormal phenotype detected	J:101977
Rela^tm1Yuo/Rela^tm1Yuo involves: 129S/SvEv	abnormal hepatocyte morphology	J:63099
	abnormal liver morphology	J:63099
	abnormal lymphocyte physiology	J:63099
	abnormal myogenesis	J:135692
	decreased B cell proliferation	J:63099
	decreased double-positive T cell number	J:63099
	decreased IgA level	J:63099
	decreased IgG1 level	J:63099
	decreased T cell proliferation	J:63099
	lethality throughout fetal growth and development, complete penetrance	J:63099
Rela^tm2.1Gho/Rela^tm2.1Gho involves: 129S6/SvEvTac * C57BL/6	abnormal bone structure	J:163663
	abnormal brain morphology	J:163663
	abnormal colon morphology	J:163663
	abnormal heart morphology	J:163663
	abnormal spleen morphology	J:163663
	decreased body size	J:163663
	distorted hair follicle pattern	J:163663
	epidermal hyperplasia	J:163663
	epidermal necrosis	J:163663
	extramedullary hematopoiesis	J:163663
	hepatic necrosis	J:163663
	increased inflammatory response	J:163663
	increased neutrophil cell number	J:163663
	interstitial pneumonia	J:163663
	liver fibrosis	J:163663
	liver hypoplasia	J:163663
	liver inflammation	J:163663
	lung inflammation	J:163663
	myositis	J:163663
	postnatal growth retardation	J:163663
	premature death	J:163663
	skin fibrosis	J:163663
	small hair follicles	J:163663
Rela^tm2.1Mpa/Rela^tm2.1Mpa involves: C57BL/6	no abnormal phenotype detected	J:148519

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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