Nfatc3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
MGI:103296

24 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nfatc3^tm1.1Grc/Nfatc3^tm1.1Grc involves: C57BL/6	decreased litter size	J:141917
	decreased survivor rate	J:141917
	normal immune system phenotype	J:141917
	lymph node hypoplasia	J:141917
	prenatal lethality, incomplete penetrance	J:141917
Nfatc3^{tm1b(EUCOMM)Hmgu}/Nfatc3⁺ C57BL/6N-Nfatc3^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal lens morphology	J:211773
	increased startle reflex	J:211773
Nfatc3^{tm1b(EUCOMM)Hmgu}/Nfatc3^{tm1b(EUCOMM)Hmgu} C57BL/6N-Nfatc3^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Nfatc3^tm1Glm/Nfatc3^tm1Glm involves: 129S2/SvPas	abnormal skeletal muscle morphology	J:68675
	decreased embryo size	J:50124
	decreased extensor digitorum longus weight	J:68675
	decreased response of heart to induced stress	J:79608
	decreased skeletal muscle fiber number	J:68675
	decreased soleus weight	J:68675
	muscle weakness	J:68675
	periorbital edema	J:50124
	prenatal lethality, incomplete penetrance	J:50124
Nfatc3^tm1Grc/Nfatc3^tm1Grc Not Specified	no abnormal phenotype detected	J:141917
Nfatc3^tm1Grc/Nfatc3^tm1Grc Tg(Lck-cre)I57Jxm/0 involves: ICR	abnormal T cell differentiation	J:141917
	decreased CD4-positive, alpha-beta T cell number	J:141917
	decreased CD8-positive, alpha-beta T cell number	J:141917
	decreased thymocyte number	J:141917
	increased double-negative T cell number	J:141917
	increased T cell apoptosis	J:141917
	lymph node hypoplasia	J:141917
	thymus hypoplasia	J:141917

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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