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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
MGI:103296
52 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfatc2tm1Glm/Nfatc2tm1Glm
Nfatc3tm1c(EUCOMM)Hmgu/Nfatc3tm1c(EUCOMM)Hmgu
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6N * CBA 		decreased interleukin-2 secretion J:346703
Nfatc2tm1Glm/Nfatc2tm1Glm
Nfatc3tm1Glm/Nfatc3tm1Glm
involves: 129S2/SvPas 		abnormal lymph node morphology J:51339
abnormal lymphocyte cell number J:51339
blepharitis J:51339
decreased T cell number J:51339
enlarged spleen J:51339
increased B cell number J:51339
increased inflammatory response J:51339
increased T cell number J:51339
interstitial pneumonia J:51339
postnatal growth retardation J:51339
Nfatc2tm1Glm/Nfatc2tm1Glm
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Grc/Nfatc4tm1Grc
involves: 129S2/SvPas 		abnormal locomotor activation J:109139
abnormal sensory neuron innervation pattern J:83744
abnormal social/conspecific interaction behavior J:109139
abnormal spinal cord dorsal column morphology J:83744
abnormal trigeminal nerve morphology J:83744
decreased anxiety-related response J:109139
decreased embryo size J:83744
decreased grip strength J:109139
hypotonia J:109139
Nfatc2tm1Rao/Nfatc2tm1Rao
Nfatc3tm1Grc/Nfatc3tm1Grc
Tg(Lck-cre)I57Jxm/0
involves: ICR 		abnormal double-negative T cell morphology J:141917
abnormal T cell differentiation J:141917
increased T cell apoptosis J:141917
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Grc/Nfatc4tm1Grc
involves: 129S2/SvPas 		abnormal blood vessel morphology J:70266
abnormal heart morphology J:84138
abnormal intersomitic vessel morphology J:70266
abnormal placental labyrinth vasculature morphology J:109139
abnormal sensory neuron innervation pattern J:83744
abnormal vitelline vasculature morphology J:70266
aganglionic megacolon J:109139
annular pancreas J:109139
embryonic lethality during organogenesis, incomplete penetrance J:70266
enlarged heart J:84138
enlarged pericardium J:70266
trabecula carnea hypoplasia J:84138
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal cardiovascular system physiology J:84138
abnormal cellular respiration J:84138
abnormal heart development J:84138
abnormal heart morphology J:84138
abnormal heart ventricle morphology J:84138
abnormal myocardial fiber mitochondrial morphology J:84138
abnormal myocardium compact layer morphology J:84138
abnormal myocardium layer morphology J:84138
abnormal trabecula carnea morphology J:84138
anemia J:84138
dilated heart J:84138
embryonic growth retardation J:84138
embryonic lethality during organogenesis, complete penetrance J:84138
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-NFATC4)#Eno/?
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB 		normal cardiovascular system phenotype J:84138
embryonic lethality during organogenesis, complete penetrance J:84138
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(TIE2-lacZ)182Sato/?
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal dorsal aorta morphology J:84138
Nfatc3tm1Glm/Nfatc3tm1Glm
Tg(DO11.10)10Dlo/?
involves: 129S2/SvPas * BALB/c * C3H * C57BL/6 		decreased double-positive T cell number J:50124
increased double-negative T cell number J:50124
small thymus J:50124
Nfatc3tm1Glm/Nfatc3tm1Glm
Tg(Myh6-Ppp3ca)37Eno/?
involves: 129S2/SvPas * FVB 		cardiac hypertrophy J:79608
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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07/02/2024
MGI 6.13 		The Jackson Laboratory