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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
MGI:103301
58 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cacnb4lh-2J/Cacnb4lh-2J
involves: C3H * C57BL/6 * DBA/2J 		impaired limb coordination J:137891
seizures J:137891
Cacnb4lh-3J/Cacnb4lh-3J
C3HeB/FeJ-Cacnb4lh-3J/GrsrJ 		abnormal gait J:88414
abnormal head movements J:88414
abnormal locomotor behavior J:88414
decreased body size J:88414
lethargy J:88414
Cacnb4lh-4J/Cacnb4lh-4J
C3Fe(SWV)-Cacnb4lh-4J/GrsrJ 		abnormal gait J:121822
normal behavior/neurological phenotype J:121822
decreased body size J:121822
normal hearing/vestibular/ear phenotype J:121822
male infertility J:121822
Cacnb4lh/Cacnb4lh
B6EiC3Sn a/A-Cacnb4lh/J 		abnormal CD4-positive, alpha-beta T cell physiology J:115345
abnormal eye electrophysiology J:136113
abnormal interleukin secretion J:115345
abnormal lymph node morphology J:5281
abnormal Peyer's patch germinal center morphology J:5281
abnormal thymus involution J:5281
absent thymus corticomedullary boundary J:5281
cachexia J:5281
decreased double-positive T cell number J:115345
decreased interferon-gamma secretion J:115345
decreased interleukin-2 secretion J:115345
decreased lymphocyte cell number J:5281
decreased Peyer's patch number J:5281
diarrhea J:5281
enlarged lymph nodes J:5281
small Peyer's patches J:5281
small spleen J:5281
small thymus J:5281
normal vision/eye phenotype J:80080
Cacnb4lh/Cacnb4lh
BALB/cGn-Cacnb4lh 		abnormal behavior J:28465
abnormal fear/anxiety-related behavior J:28465
abnormal locomotor activation J:28465
abnormal thymus involution J:12166
absent corpus luteum J:12166
increased length of allograft survival J:5766
pituitary gland hyperplasia J:12166
postnatal growth retardation J:12166
premature death J:12166
reduced fertility J:12166
Cacnb4lh/Cacnb4lh
involves: BALB/cGn 		abnormal gait J:28466
abnormal nerve conduction J:6556
convulsive seizures J:28466
decreased nerve conduction velocity J:6556
increased IgG1 level J:5883
lethargy J:28466
Cacnb4lh/Cacnb4lh
involves: BALB/cGn * C3H/HeSnJ * C57BL/6JEi 		abnormal brain wave pattern J:1484, J:79139
abnormal CNS synaptic transmission J:106959
abnormal motor capabilities/coordination/movement J:79139
abnormal motor neuron morphology J:121463
abnormal neuromuscular synapse morphology J:121463
abnormal posture J:79139
ataxia J:79139
circling J:79139
clonic seizures J:79139
decreased locomotor activity J:79139
facial muscle spasm J:79139
impaired behavioral response to xenobiotic J:1484
impaired coordination J:79139
impaired righting response J:79139
normal nervous system phenotype J:121463
seizures J:1484
tonic seizures J:79139
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory