Cacnb3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
MGI:103307

22 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cacnb3^tm1Acv/Cacnb3^tm1Acv involves: 129S1/Sv * 129X1/SvJ	abnormal calcium ion homeostasis	J:86381
	abnormal CD4-positive, alpha-beta T cell physiology	J:115345
	abnormal interleukin secretion	J:115345
	abnormal vascular smooth muscle morphology	J:86381
	abnormal vascular smooth muscle physiology	J:86381
	decreased interferon-gamma secretion	J:115345
	enlarged heart	J:86381
	increased heart weight	J:86381
	increased systemic arterial blood pressure	J:86381
	increased systemic arterial diastolic blood pressure	J:86381
	increased systemic arterial systolic blood pressure	J:86381
	vascular smooth muscle hypertrophy	J:86381
Cacnb3^tm1Hssh/Cacnb3^tm1Hssh involves: 129/Sv * 129S4/SvJae	abnormal channel response	J:50152
	normal nervous system phenotype	J:50152
	normal vision/eye phenotype	J:80080
Cacnb3^tm1Hssh/Cacnb3^tm1Hssh involves: 129S4/SvJae * C57BL/6J	abnormal discrimination learning	J:136837
	abnormal optic tract morphology	J:72711
	abnormal sensory neuron innervation pattern	J:72711
	enhanced contextual conditioning behavior	J:136837
	enhanced long-term object recognition memory	J:136837
	enhanced long-term potentiation	J:136837
	enhanced NMDA-mediated synaptic currents	J:136837
	normal nervous system phenotype	J:136837

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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