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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Clcn3
chloride channel, voltage-sensitive 3
MGI:103555
71 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Clcn3tm1.1Jrhm/Clcn3tm1.1Jrhm
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-cre)3Jig/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal heart echocardiography feature J:222375
abnormal myocardial fiber physiology J:222375
congestive heart failure J:222375
decreased heart left ventricle muscle contractility J:222375
dilated cardiomyopathy J:222375
enlarged heart J:222375
increased heart weight J:222375
myocardium hypertrophy J:222375
premature death J:222375
Clcn3tm1Lamb/Clcn3tm1Lamb
involves: 129S1/Sv * 129X1/SvJ 		abnormal excitatory postsynaptic currents J:122982
abnormal excitatory postsynaptic potential J:122982
abnormal neutrophil physiology J:112692
impaired neutrophil phagocytosis J:112692
increased susceptibility to induced morbidity/mortality J:112692
sepsis J:112692
Clcn3tm1Lamb/Clcn3tm1Lamb
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal abdominal fat pad morphology J:80901
abnormal behavioral response to xenobiotic J:80901
abnormal brain morphology J:80901
abnormal entorhinal cortex morphology J:80901
abnormal gait J:80901
abnormal hippocampus morphology J:80901
abnormal nervous system morphology J:80901
abnormal nervous system physiology J:80901
astrocytosis J:80901
decreased body weight J:80901
decreased cerebral cortex pyramidal cell number J:80901
decreased circulating glucose level J:80901
decreased hippocampus pyramidal cell number J:80901
decreased retina photoreceptor cell number J:80901
decreased susceptibility to pharmacologically induced seizures J:80901
enhanced behavioral response to xenobiotic J:80901
enlarged lateral ventricles J:80901
gliosis J:80901
hippocampal neuron degeneration J:80901
impaired coordination J:80901
increased susceptibility to age-related retinal degeneration J:80901
kyphosis J:80901
lethality at weaning, incomplete penetrance J:80901
loss of GABAergic neurons J:80901
postnatal growth retardation J:80901
premature death J:80901
reduced fertility J:80901
reduced male fertility J:80901
seizures J:80901
stereotypic behavior J:80901
tonic-clonic seizures J:80901
Clcn3tm1Suc/Clcn3tm1Suc
involves: 129P2/OlaHsd * C57BL/6 		abnormal astrocyte morphology J:96311
abnormal hippocampus pyramidal cell morphology J:96311
abnormal ileum morphology J:96311
abnormal liver physiology J:96150, J:96311
abnormal retina neuronal layer morphology J:96311
blindness J:96311
decreased body weight J:96311
decreased hippocampus pyramidal cell number J:96311
hippocampus atrophy J:96311
hyperactivity J:96311
impaired coordination J:96311
kyphoscoliosis J:96311
premature death J:96311
Clcn3tm1Tjj/Clcn3tm1Tjj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal eye electrophysiology J:77635
abnormal eye morphology J:77635
abnormal eye physiology J:77635
abnormal hippocampus morphology J:77635
abnormal hippocampus pyramidal cell morphology J:77635
abnormal microglial cell physiology J:77635
abnormal motor capabilities/coordination/movement J:77635
abnormal nervous system morphology J:77635
abnormal nervous system physiology J:77635
abnormal posture J:77635
abnormal response to new environment J:77635
abnormal synaptic vesicle morphology J:77635
blindness J:77635
decreased body weight J:77635
decreased brain size J:77635
decreased retina photoreceptor cell number J:77635
disorganized photoreceptor outer segment J:77635
hippocampal neuron degeneration J:77635
impaired coordination J:77635
impaired synaptic plasticity J:77635
increased locomotor activity J:77635
increased susceptibility to age-related retinal degeneration J:77635
photoreceptor inner segment degeneration J:77635
photoreceptor outer segment degeneration J:77635
premature death J:77635
normal renal/urinary system phenotype J:164474
small hippocampus J:77635
stereotypic behavior J:77635
tremors J:77635
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory