Cxcl12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cxcl12
C-X-C motif chemokine ligand 12
MGI:103556

41 phenotypes from 10 alleles in 19 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cxcl12^{tm1.1(KOMP)Vlcg}/Cxcl12⁺ C57BL/6N-Cxcl12^{tm1.1(KOMP)Vlcg}/Ucd	abnormal uterus morphology	J:211773
	enlarged uterus	J:211773
	hydrometra	J:211773
	thrombocytopenia	J:211773
Cxcl12^{tm1.1(KOMP)Vlcg}/Cxcl12^{tm1.1(KOMP)Vlcg} C57BL/6N-Cxcl12^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
Cxcl12^tm1.1Fass/Cxcl12^tm1.1Fass involves: 129S6/SvEvTac * C57BL/6NTac	abnormal physiological neovascularization	J:209558
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Commd10^{Tg(Vav1-icre)A2Kio}/? involves: C57BL/6 * C57BL/10 * CBA/Ca	normal hematopoietic system phenotype	J:194748
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Lepr^tm2(cre)Rck/Lepr⁺ involves: C57BL/6	abnormal hematopoietic system morphology/development	J:194748
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/? involves: 129S/SvEv * C57BL/6	decreased bone marrow cell number	J:194748
	decreased hematopoietic stem cell number	J:194748
	decreased leukocyte cell number	J:194748
	decreased lymphocyte cell number	J:194748
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Tg(Col1a1-cre)2Bek/? involves: C57BL/6 * CD-1	abnormal bone marrow cell physiology	J:194748
	decreased bone marrow cell number	J:194748
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Tg(Nes-cre)1Kln/? involves: C57BL/6 * SJL	normal hematopoietic system phenotype	J:194748
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Tg(Prrx1-cre)1Cjt/? involves: C57BL/6 * SJL/J	abnormal B cell differentiation	J:194748
	decreased bone marrow cell number	J:194748
Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Tg(Tek-cre)12Flv/? involves: C3H * C57BL/6	abnormal bone marrow cell physiology	J:194748
	decreased hematopoietic stem cell number	J:194748
Cxcl12^tm1.1Ystz/Cxcl12^tm1.2Ystz Tg(CAG-cre/Esr1)5Amc/0 involves: 129X1/SvJ C57BL/6 * CBA * FVB/N	abnormal hematopoietic stem cell physiology	J:168434
	abnormal hematopoietic system physiology	J:168434
	decreased hematopoietic stem cell number	J:168434
	decreased pro-B cell number	J:168434
	increased hematopoietic stem cell number	J:168434
	increased neutrophil cell number	J:168434
Cxcl12^tm1.2Sjm/Cxcl12^tm1.2Sjm involves: BALB/cJ * C57BL/6	prenatal lethality, complete penetrance	J:194748
Cxcl12^tm1Tng/Cxcl12^tm1.1Link Tg(BGLAP-cre)1Clem/0 involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * FVB/N	decreased B cell number	J:193594
	normal hematopoietic system phenotype	J:193594
Cxcl12^tm1Tng/Cxcl12^tm1.1Link Tg(Prrx1-cre)1Cjt/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J	abnormal bone marrow cell physiology	J:193594
	abnormal common lymphocyte progenitor cell morphology	J:193594
	abnormal hematopoietic stem cell physiology	J:193594
	decreased B cell number	J:193594
	decreased bone marrow cell number	J:193594
	decreased common myeloid progenitor cell number	J:193594
	decreased hematopoietic stem cell number	J:193594
	decreased pre-pro B cell number	J:193594
Cxcl12^tm1Tng/Cxcl12^tm1.1Link Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N	abnormal blood cell morphology/development	J:193594
	abnormal hematopoietic stem cell physiology	J:193594
	decreased B cell number	J:193594
	decreased bone marrow cell number	J:193594
	decreased hematopoietic stem cell number	J:193594
	decreased pre-pro B cell number	J:193594
Cxcl12^tm1Tng/Cxcl12^tm1.1Link Tg(Tek-cre)1Ywa/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	abnormal bone marrow cell physiology	J:193594
	normal hematopoietic system phenotype	J:193594
Cxcl12^tm1Tng/Cxcl12^tm1Tng B6.Cg-Cxcl12^tm1Tng	abnormal primordial germ cell migration	J:83291
Cxcl12^tm1Tng/Cxcl12^tm1Tng involves: 129P2/OlaHsd	abnormal angiogenesis	J:69256
	abnormal cerebellum morphology	J:49070
	abnormal developmental vascular remodeling	J:195048
	abnormal skin vasculature morphology	J:195048
	abnormal vascular smooth muscle morphology	J:195048
	decreased bone marrow cell number	J:34750, J:49070
	decreased pre-B cell number	J:34750
	decreased pro-B cell number	J:34750
	impaired myelopoiesis	J:49070
	lethality throughout fetal growth and development, incomplete penetrance	J:34750
	neonatal lethality, complete penetrance	J:34750
	normal nervous system phenotype	J:195048
	perimembraneous ventricular septal defect	J:34750
	poor arterial differentiation	J:195048
	thin external granule cell layer	J:49070
Cxcl12^tm2Tng/Cxcl12⁺ B6.Cg-Cxcl12^tm2Tng	no abnormal phenotype detected	J:82996
Tg(Ins2-Cxcl12)2Cys/0 involves: C57BL/6 * DBA/2	abnormal pancreatic islet morphology	J:77238

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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