Xpc Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xpc
xeroderma pigmentosum, complementation group C
MGI:103557

30 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apex1^tm1Ecf/Apex1⁺ Xpc^tm1Ecf/Xpc^tm1Ecf involves: 129	increased tumor incidence	J:70397
Apex1^tm1Ecf/Apex1⁺ Xpc^tm1Ecf/Xpc^tm1Ecf involves: 129	oxidative stress	J:70397
Ercc3^tm1.1Gima/Ercc3^tm1.1Gima Xpc^tm1Ecf/Xpc^tm1Ecf either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * FVB/N)	increased cellular sensitivity to ultraviolet irradiation	J:154596
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpc^tm1Brd/Xpc^tm1Brd involves: 129P2/OlaHsd * 129S7/SvEvBrd	abnormal gait	J:182229
	abnormal myelin sheath morphology	J:182229
	abnormal myelination	J:182229
	abnormal oligodendrocyte physiology	J:182229
	ataxia	J:182229
	cachexia	J:182229
	impaired coordination	J:182229
	lethality at weaning, complete penetrance	J:182229
	limb grasping	J:182229
	postnatal growth retardation	J:182229
	short stride length	J:182229
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpc^tm1Ecf/Xpc^tm1Ecf involves: 129 * 129P2/OlaHsd * C57BL/6J	abnormal base-excision repair	J:122013
	cachexia	J:122013
	disproportionate dwarf	J:122013
	increased cellular sensitivity to ultraviolet irradiation	J:122013
	perinatal lethality, incomplete penetrance	J:122013
	postnatal growth retardation	J:122013
	postnatal lethality, complete penetrance	J:122013
Ercc8^tm1Jhjh/Ercc8^tm1Jhjh Xpc^tm1Ecf/Xpc⁺ involves: 129P2/OlaHsd * C57BL/6J	increased incidence of tumors by UV-induction	J:74959
Ercc8^tm1Jhjh/Ercc8^tm1Jhjh Xpc^tm1Ecf/Xpc^tm1Ecf involves: 129P2/OlaHsd * C57BL/6J	decreased body size	J:74959
	premature death	J:74959
Gadd45a^tm1Ajf/Gadd45a^tm1Ajf Xpc^tm1Ecf/Xpc^tm1Ecf either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)	increased lung adenocarcinoma incidence	J:101421
	increased lung adenoma incidence	J:101421
	increased lung tumor incidence	J:101421
	increased metastatic potential	J:101421
	premature death	J:101421
Mc1r^e/Mc1r^e Xpc^tm1Brd/Xpc^tm1Brd Tg(KRT14-Kitl)1Takk/0 involves: 129S7/SvEvBrd * C57BL/6 * SJL	increased squamous cell carcinoma incidence	J:112959
	increased tumor incidence	J:112959
	skin lesions	J:112959
	thick epidermis	J:112959
	weight loss	J:112959
Msh2^tm1Rak/Msh2^tm1Rak Xpc^tm1Ecf/Xpc^tm1Ecf involves: 129P2/OlaHsd * SKH1	abnormal cell cycle	J:94447
	increased cellular sensitivity to ultraviolet irradiation	J:94447

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24