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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sox18
SRY (sex determining region Y)-box 18
MGI:103559
47 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sox18Mhdadcc1/Sox18+
C3HeB/FeJ-Sox18Mhdadcc1/Ieg 		darkened coat color J:81301
Sox18Mhdadcc1/Sox18Mhdadcc1
C3HeB/FeJ-Sox18Mhdadcc1/Ieg 		abnormal hair growth J:81301
darkened coat color J:81301
sparse hair J:81301
Sox18Ra-J/Sox18+
involves: C3H/HeSnJ 		darkened coat color J:30359
retarded hair growth J:30359
short vibrissae J:30359
sparse hair J:30359
Sox18Ra-J/Sox18Ra-J
involves: C3H/HeSnJ 		abnormal vibrissa number J:30359
decreased body size J:30359
hairless J:30359
neonatal lethality, incomplete penetrance J:30359
Sox18Ra-Op/Sox18+
involves: C57BL/6J * DBA/2J 		abnormal awl hair morphology J:260
abnormal hair follicle morphology J:279
abnormal hair growth J:260, J:279
abnormal vibrissa morphology J:279
abnormal vibrissa number J:260
abnormal zigzag hair morphology J:279
absent auchene hairs J:260
cyanosis J:260
decreased body size J:260, J:279
decreased zigzag hair amount J:260, J:279
delayed hair appearance J:260, J:279
distended abdomen J:279
edema J:260, J:279
perinatal lethality, incomplete penetrance J:260, J:279
postnatal lethality, incomplete penetrance J:260, J:279
short vibrissae J:279
skin edema J:260
sparse hair J:260, J:279
Sox18Ra-Op/Sox18Ra-Op
B6D2-Sox18Ra-Op/J 		abnormal blood vessel morphology J:150211
abnormal lymphatic vessel morphology J:143564
abnormal pericyte morphology J:150211
abnormal vascular endothelial cell physiology J:150211
normal cardiovascular system phenotype J:150211
edema J:150211
hematoma J:150211
hemorrhage J:150211
increased vascular endothelial cell number J:150211
lethality throughout fetal growth and development, complete penetrance J:143564, J:150211
skin edema J:143564, J:150211
Sox18Ra-Op/Sox18Ra-Op
involves: C57BL/6J * DBA/2J 		embryonic lethality, complete penetrance J:279
preweaning lethality, complete penetrance J:260
Sox18Ra/Sox18+
involves: AG/Cam 		chylous ascites J:6220, J:13089
decreased total body fat amount J:13089
intestinal fibrosis J:13089
retarded hair growth J:13089
Sox18Ra/Sox18+
Not Specified 		abnormal hair follicle morphology J:12991
abnormal zigzag hair morphology J:86
absent auchene hairs J:86
chylous ascites J:13089
darkened coat color J:86
retarded hair growth J:86
sparse hair J:86
Sox18Ra/Sox18Ra
Not Specified 		alopecia J:86
edema J:86
preweaning lethality, incomplete penetrance J:86
Sox18Ragl/Sox18+
involves: 129P3/J * C57BL/6J 		chylous ascites J:83731
disheveled coat J:83731
edema J:83731
sparse hair J:83731
Sox18Ragl/Sox18Ragl
involves: 129P3/J * C57BL/6J 		chylous ascites J:83731
edema J:83731
embryonic lethality, incomplete penetrance J:83731
hairless J:83731
neonatal lethality, complete penetrance J:83731
Sox18tm1(GFP/cre/ERT2)Pzg/Sox18+
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:159099
Sox18tm1.1(KOMP)Vlcg/Sox18tm1.1(KOMP)Vlcg
C57BL/6N-Sox18tm1.1(KOMP)Vlcg/J 		abnormal behavior J:211773
decreased thigmotaxis J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating sodium level J:211773
increased mean corpuscular hemoglobin J:211773
Sox18tm1Koop/Sox18+
B6.129-Sox18tm1Koop 		skin edema J:143564
Sox18tm1Koop/Sox18tm1Koop
B6.129-Sox18tm1Koop 		abnormal lymphatic vessel morphology J:143564
lethality throughout fetal growth and development, complete penetrance J:143564
skin edema J:143564
Sox18tm1Koop/Sox18tm1Koop
involves: 129/Sv * CD-1 		abnormal hair growth J:66010
darkened coat color J:66010
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory