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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
MGI:103562
43 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hsd11b1tm1.1Awhi/Hsd11b1tm1.1Awhi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal growth/size/body region phenotype J:207713
normal homeostasis/metabolism phenotype J:207713
increased food intake J:207713
Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
involves: 129P2/OlaHsd 		abnormal enzyme/coenzyme activity J:141273
decreased circulating corticosterone level J:189059
enlarged adrenal glands J:189059
Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		enlarged adrenal glands J:189132
normal muscle phenotype J:189132
Hsd11b1tm1.2Awhi/Hsd11b1tm1.2Awhi
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal food intake J:207713
normal growth/size/body region phenotype J:207713
normal homeostasis/metabolism phenotype J:207713
Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal circulating insulin level J:203302
abnormal epididymal fat pad morphology J:203302
decreased susceptibility to weight gain J:203302
normal homeostasis/metabolism phenotype J:203302
Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1+
involves: C57BL/6Jcl * C57BL/6N 		abnormal corticosterone level J:214146
decreased collagen level J:214146
increased circulating corticosterone level J:214146
increased fibroblast proliferation J:214146
Hsd11b1tm1a(KOMP)Wtsi/Hsd11b1tm1a(KOMP)Wtsi
involves: C57BL/6Jcl * C57BL/6N 		abnormal corticosterone level J:214146
abnormal fibroblast proliferation J:214146
decreased collagen level J:214146
increased circulating corticosterone level J:214146
increased fibroblast proliferation J:214146
increased subcutaneous adipose tissue amount J:214146
Hsd11b1tm1Ggla/Hsd11b1tm1Ggla
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal eating behavior J:189059
abnormal glucose tolerance J:189059
decreased circulating corticosterone level J:189059
decreased circulating insulin level J:189059
enlarged adrenal glands J:189059
normal growth/size/body region phenotype J:189059
normal homeostasis/metabolism phenotype J:189059
increased circulating HDL cholesterol level J:189059
normal liver/biliary system phenotype J:189059
Hsd11b1tm1Yko/Hsd11b1tm1Yko
B6.129P2(Cg)-Hsd11b1tm1Yko 		abnormal abdominal fat pad morphology J:89080
abnormal epididymal fat pad morphology J:89080
decreased circulating LDL cholesterol level J:89080
improved glucose tolerance J:89080
increased circulating HDL cholesterol level J:89080
Hsd11b1tm1Yko/Hsd11b1tm1Yko
involves: 129P2/OlaHsd * MF1 		abnormal abdominal fat pad morphology J:89080
abnormal amniotic fluid composition J:80523
abnormal brainstem morphology J:68825
abnormal circulating cholesterol level J:72402
abnormal corticosterone level J:45085, J:67184
abnormal epididymal fat pad morphology J:89080
abnormal glucose homeostasis J:37960
abnormal hippocampus morphology J:68825
abnormal lipid homeostasis J:72402
abnormal lung development J:80523
abnormal pulmonary alveolus morphology J:80523
abnormal spatial learning J:68825
absent alveolar lamellar bodies J:80523
decreased alveolar lamellar body number J:80523
decreased circulating glucose level J:37960, J:45085
decreased circulating triglyceride level J:72402
decreased surfactant secretion J:80523
enlarged adrenal glands J:37960, J:45085
hepatic steatosis J:72402
improved glucose tolerance J:72402
increased circulating cholesterol level J:72402
increased circulating HDL cholesterol level J:72402
increased liver glycogen level J:45085
small alveolar lamellar bodies J:80523
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory