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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hand1
heart and neural crest derivatives expressed 1
MGI:103577
115 phenotypes from 11 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hand1tm1.1(EGFP/cre)Abfi/Hand1+
involves: 129S/SvEv * 129S4/SvJaeSor 		no abnormal phenotype detected J:165398
Hand1tm1.1(EGFP/cre)Abfi/Hand1tm1.1(EGFP/cre)Abfi
involves: 129S/SvEv * 129S4/SvJaeSor 		embryonic lethality during organogenesis, complete penetrance J:165398
Hand1tm1Cse/Hand1tm1Cse
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster) 		abnormal extraembryonic endoderm formation J:89474
abnormal vitelline vascular remodeling J:89474
embryonic lethality, complete penetrance J:89474
Hand1tm1Cse/Hand1tm1Cse
involves: 129S1/Sv 		embryonic lethality between implantation and somite formation, complete penetrance J:89474
Hand1tm1Eno/Hand1+
involves: 129S7/SvEvBrd * C57BL/6 		no abnormal phenotype detected J:46384
Hand1tm1Eno/Hand1tm1Eno
involves: 129S7/SvEvBrd * C57BL/6 		abnormal amnion morphology J:46384
abnormal chorioallantoic fusion J:46384
abnormal chorion morphology J:46384
abnormal embryo turning J:46384
abnormal heart development J:46384
abnormal heart looping J:46384
abnormal neural tube morphology J:46384
absent vitelline blood vessels J:46384
embryonic growth retardation J:46384
embryonic lethality during organogenesis, complete penetrance J:46384
excessive folding of visceral yolk sac J:46384
Hand1tm1Eno/Hand1tm2Eno
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		no abnormal phenotype detected J:94514
Hand1tm1Eno/Hand1tm2Eno
Tg(Myh6-cre)2182Mds/0
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal atrioventricular cushion morphology J:94514
abnormal atrioventricular valve morphology J:94514
abnormal interventricular septum muscular part morphology J:94514
cyanosis J:94514
decreased heart left ventricle size J:94514
double outlet right ventricle J:94514
overriding aortic valve J:94514
perimembraneous ventricular septal defect J:94514
postnatal lethality, incomplete penetrance J:94514
Hand1tm1Eno/Hand1tm2Eno
Tg(Nkx2-5-cre)9Eno/0
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal heart morphology J:94514
postnatal lethality, complete penetrance J:94514
Hand1tm1Jcc/Hand1+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:46383
Hand1tm1Jcc/Hand1tm1Jcc
involves: 129S1/Sv * 129X1/SvJ 		abnormal embryo implantation J:202357
abnormal extraembryonic tissue morphology J:202357
abnormal spongiotrophoblast cell morphology J:202357
embryonic lethality, complete penetrance J:202357
failure of heart looping J:202357
Hand1tm1Jcc/Hand1tm1Jcc
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal extraembryonic tissue morphology J:46383
abnormal parietal yolk sac morphology J:46383
abnormal trophoblast giant cell morphology J:46383
abnormal visceral yolk sac morphology J:46383
decreased trophoblast giant cell number J:46383
embryonic growth arrest J:46383
embryonic lethality during organogenesis, complete penetrance J:46383
small ectoplacental cone J:46383
Hand1tm1Jcc/Hand1tm2.1Jcc
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial morphology J:202357
abnormal heart morphology J:202357
abnormal metencephalon morphology J:202357
abnormal pharyngeal arch development J:202357
abnormal placenta labyrinth morphology J:202357
abnormal placenta morphology J:202357
abnormal telencephalon development J:202357
decreased spongiotrophoblast cell number J:202357
embryonic lethality during organogenesis, incomplete penetrance J:202357
lethality, incomplete penetrance J:202357
pale yolk sac J:202357
Hand1tm2(Hand1)Abfi/Hand1tm2(Hand1)Abfi
Not Specified 		abnormal cardiac outflow tract development J:164028
abnormal heart morphology J:164028
abnormal heart septum morphology J:164028
abnormal mesoderm development J:164028
abnormal myocardial trabeculae morphology J:164028
abnormal neural tube morphology J:164028
abnormal visceral yolk sac morphology J:164028
decreased cell proliferation J:164028
dilated heart J:164028
embryonic lethality during organogenesis, complete penetrance J:164028
enlarged allantois J:164028
enlarged heart J:164028
impaired placental function J:164028
Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi
Not Specified 		abnormal cardiac outflow tract development J:164028
abnormal cardiovascular system morphology J:164028
abnormal craniofacial morphology J:164028
abnormal embryo development J:164028
abnormal embryo turning J:164028
abnormal interventricular septum morphology J:164028
abnormal limb bud morphology J:164028
abnormal rostral-caudal axis patterning J:164028
decreased cell proliferation J:164028
decreased embryo size J:164028
embryonic lethality during organogenesis, incomplete penetrance J:164028
hemopericardium J:164028
thin ventricular wall J:164028
Hand1tm2.1Jcc/Hand1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial morphology J:202357
abnormal heart morphology J:202357
abnormal placenta development J:202357
Hand1tm2.1Jcc/Hand1tm2.1Jcc
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial morphology J:202357
abnormal embryo implantation J:202357
abnormal heart development J:202357
abnormal heart morphology J:202357
abnormal metencephalon morphology J:202357
abnormal pharyngeal arch development J:202357
abnormal placenta development J:202357
abnormal placenta labyrinth morphology J:202357
abnormal placenta morphology J:202357
abnormal somite development J:202357
abnormal telencephalon development J:202357
decreased body length J:202357
decreased spongiotrophoblast cell number J:202357
embryonic lethality during organogenesis, complete penetrance J:202357
pale yolk sac J:202357
thin ventricular wall J:202357
ventricular hypoplasia J:202357
Hand1tm2Eno/Hand1tm2Eno
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		no abnormal phenotype detected J:94514
Hand1tm2Eno/Hand1tm3Abfi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal craniofacial development J:214092
abnormal maxillary prominence morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal secondary palate development J:214092
abnormal tongue position J:214092
absent nasal septum J:214092
basisphenoid bone hypoplasia J:214092
midline facial cleft J:214092
nasal bone hypoplasia J:214092
neonatal lethality J:214092
Hand1tm2Eno/Hand1tm4Abfi
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: 129S6/SvEvTac * C3H * C57BL/6 		abnormal craniofacial development J:214092
abnormal maxillary prominence morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal secondary palate development J:214092
absent middle ear ossicles J:214092
absent nasal septum J:214092
decreased maxillary shelf size J:214092
decreased palatine bone horizontal plate size J:214092
mandible hypoplasia J:214092
middle ear ossicle hypoplasia J:214092
midline facial cleft J:214092
neonatal lethality J:214092
temporal bone squamous part hypoplasia J:214092
Hand1tm3Abfi/Hand1+
Tg(Mpz-cre)94Imeg/0
Not Specified 		abnormal nasal capsule morphology J:214092
abnormal palate development J:214092
small frontal bone J:214092
small nasal bone J:214092
Hand1tm3Abfi/Hand1+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 		abnormal alisphenoid bone morphology J:214092
abnormal basicranium morphology J:214092
abnormal maxilla morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal Reichert's cartilage morphology J:214092
abnormal sagittal suture morphology J:214092
abnormal secondary palate development J:214092
abnormal tongue position J:214092
absent nasal bone J:214092
absent nasal septum J:214092
absent temporal bone squamous part J:214092
basisphenoid bone hypoplasia J:214092
frontal bone hypoplasia J:214092
interparietal bone hypoplasia J:214092
mandible hypoplasia J:214092
midline facial cleft J:214092
neonatal lethality J:214092
pterygoid bone hypoplasia J:214092
short Meckel's cartilage J:214092
short premaxilla J:214092
zygomatic bone hypoplasia J:214092
Hand1tm4Abfi/Hand1+
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 		abnormal alisphenoid bone morphology J:214092
abnormal nasal capsule morphology J:214092
abnormal palatal shelf fusion at midline J:214092
abnormal pharyngeal arch morphology J:214092
abnormal tongue position J:214092
absent nasal septum J:214092
midline facial cleft J:214092
nasal bone hypoplasia J:214092
neonatal lethality J:214092
premaxilla hypoplasia J:214092
small mandible J:214092
temporal bone squamous part hypoplasia J:214092
Hand1tm5Abfi/Hand1+
Tg(Myh6-cre)2182Mds/0
involves: FVB/N 		abnormal heart apex morphology J:311466
cardiac hypertrophy J:311466
lethality during fetal growth through weaning, incomplete penetrance J:311466
Hand1tm5Abfi/Hand1+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd 		abnormal cardiac outflow tract development J:311466
abnormal interventricular septum morphology J:311466
abnormal myocardial trabeculae morphology J:311466
cardiac edema J:311466
decreased heart right ventricle size J:311466
hemorrhage J:311466
increased cell death J:311466
lethality throughout fetal growth and development, complete penetrance J:311466
thin left ventricle myocardium compact layer J:311466
thin myocardium J:311466
ventricular septal defect J:311466
Hand1tm5Abfi/Hand1+
Tg(Mef2c-cre)2Blk/0
Not Specified 		abnormal cardiac outflow tract development J:311466
decreased heart right ventricle size J:311466
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory