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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hand1
heart and neural crest derivatives expressed 1
MGI:103577
24 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hand1tm1(tTA)Prri/Hand1+
Tg(tetO-Hand1)1Prri/0
involves: 129/Sv * C57BL/6 		abnormal cardiac outflow tract development J:116090
abnormal fetal cardiomyocyte proliferation J:116090
abnormal heart development J:116090
abnormal heart left ventricle morphology J:116090
abnormal heart looping J:116090
abnormal heart tube morphology J:116090
abnormal myocardial fiber morphology J:116090
embryonic lethality during organogenesis, incomplete penetrance J:116090
Hand1tm1Eno/Hand1+
Rr133tm1Eno/Rr133tm1Eno
Not Specified 		abnormal heart ventricle morphology J:94514
abnormal myocardium layer morphology J:94514
embryonic lethality during organogenesis, complete penetrance J:94514
Hand1tm1Eno/Hand1+
Hand2os1em1Eno/Hand2os1+
involves: 129S7/SvEvBrd * C57BL/6 		common ventricle J:241318
embryonic growth retardation J:241318
embryonic lethality, complete penetrance J:241318
pericardial effusion J:241318
Hand1tm1Eno/Hand1tm2Eno
Rr133tm1Eno/Rr133+
Tg(Nkx2-5-cre)9Eno/0
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal myocardial trabeculae morphology J:94514
embryonic growth retardation J:94514
embryonic lethality during organogenesis, complete penetrance J:94514
thin myocardium J:94514
Hand1tm1Eno/Hand1tm2Eno
Rr133tm1Eno/Rr133tm1Eno
Tg(Nkx2-5-cre)9Eno/0
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal heart atrium morphology J:94514
abnormal heart ventricle morphology J:94514
abnormal myocardium layer morphology J:94514
embryonic lethality between somite formation and embryo turning, complete penetrance J:94514
trabecula carnea hypoplasia J:94514
Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi
Hand2tm1Dsr/Hand2tm1Dsr
involves: 129S7/SvEvBrd 		abnormal cardiovascular system morphology J:164028
abnormal rostral-caudal axis patterning J:164028
decreased embryo size J:164028
thin ventricular wall J:164028
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory