About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hand2
heart and neural crest derivatives expressed 2
MGI:103580
101 phenotypes from 18 alleles in 17 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Hand2tm1.1Majh/Hand2tm1.1Majh
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/SvImJ * C57BL/6J * CBA/J * DBA/2 		abnormal craniofacial bone morphology J:137726
abnormal enteric ganglia morphology J:138032
abnormal enteric nervous system morphology J:138032
abnormal enteric neuron morphology J:138032
abnormal heart development J:137726
abnormal neuron differentiation J:137726
abnormal sympathetic ganglion morphology J:137726
decreased embryo size J:137726
embryonic lethality during organogenesis, complete penetrance J:137726
normal nervous system phenotype J:137726
short mandible J:137726
Hand2tm1.1Zllr/Hand2tm1.2Zllr
Tg(Prrx1-cre)1Cjt/0
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL 		abnormal autopod morphology J:159210
abnormal digit development J:159210
abnormal forelimb zeugopod morphology J:159210
abnormal hindlimb morphology J:159210
abnormal interdigital cell death J:159210
increased apoptosis J:159210
Hand2tm1.2Zllr/Hand2tm1.2Zllr
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL 		abnormal pharyngeal arch artery morphology J:159210
dilated aortic sac J:159210
distended pericardium J:159210
embryonic growth retardation J:159210
increased embryonic tissue cell apoptosis J:159210
Hand2tm1Cse/Hand2+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * C57BL/6J * CBA/J 		aberrant origin of the right subclavian artery J:155265
abnormal cell cycle J:155265
abnormal fetal cardiomyocyte proliferation J:155265
abnormal myocardial trabeculae morphology J:155265
abnormal thymus development J:155265
normal embryo phenotype J:155265
heart right ventricle hypertrophy J:155265
interrupted aortic arch J:155265
lethality throughout fetal growth and development, complete penetrance J:155265
perimembraneous ventricular septal defect J:155265
pulmonary artery stenosis J:155265
retroesophageal right subclavian artery J:155265
Hand2tm1Cse/Hand2+
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * C57BL/6J * DBA/2 		abnormal cardiac outflow tract development J:155265
abnormal heart ventricle morphology J:155265
decreased heart right ventricle size J:155265
embryonic lethality during organogenesis, complete penetrance J:155265
Hand2tm1Cse/Hand2+
Tg(Hoxb6-cre)#Mku/0
involves: 129S1/Sv * FVB/N 		abnormal limb development J:155265
normal cardiovascular system phenotype J:155265
normal embryo phenotype J:155265
normal mortality/aging J:155265
Hand2tm1Cse/Hand2+
Tg(DBH-cre)1Cse/0
involves: 129S1/Sv 		embryonic lethality during organogenesis, complete penetrance J:155265
liver vascular congestion J:155265
visceral vascular congestion J:155265
Hand2tm1Cse/Hand2tm1Cse
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA 		normal craniofacial phenotype J:149232
Hand2tm1Cse/Hand2tm1Cse
Osr2tm2(cre)Jian/Osr2+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		mandible hypoplasia J:149232
Hand2tm1Cse/Hand2tm1Cse
Tg(Pitx2-cre)1Ych/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		cleft secondary palate J:149232
failure of palatal shelf elevation J:149232
Hand2tm1Cse/Hand2tm1Dsr
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		abnormal palatal shelf elevation J:149232
abnormal primary and secondary palatal fusion J:122604
abnormal suckling behavior J:122604
cleft secondary palate J:122604
decreased palatal shelf size J:149232
neonatal lethality, complete penetrance J:122604
palatal shelves fail to meet at midline J:149232
tongue hypoplasia J:149232
Hand2tm1Cse/Hand2tm1Dsr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal adrenergic neuron morphology J:122604
abnormal blood circulation J:122604
abnormal enzyme/coenzyme level J:122604
embryonic lethality during organogenesis, complete penetrance J:122604
normal nervous system phenotype J:122604
visceral vascular congestion J:122604
Hand2tm1Dsr/Hand2tm1Dsr
involves: 129 * 129S7/SvEvBrd * C57BL/6 		heart right ventricle hypoplasia J:169213
increased apoptosis J:169213
Hand2tm1Dsr/Hand2tm1Dsr
involves: 129S7/SvEvBrd 		abnormal cardiac outflow tract development J:40768
abnormal first pharyngeal arch artery morphology J:40768
abnormal forelimb bud morphology J:62028
abnormal forelimb morphology J:62028
abnormal heart looping J:40768
abnormal heart ventricle morphology J:40768
abnormal pharyngeal arch artery morphology J:40768
absent heart right ventricle J:40768
absent myocardial trabeculae J:40768
absent second pharyngeal arch artery J:40768
absent trabeculae carneae J:40768
congestive heart failure J:40768
decreased cardiac muscle contractility J:40768
decreased embryo size J:40768
decreased somite size J:62028
dilated aortic sac J:40768
edema J:62028
embryonic growth retardation J:40768
embryonic lethality during organogenesis, complete penetrance J:40768
pericardial effusion J:40768
poor circulation J:62028
small forelimb buds J:62028
thin myocardium J:40768
Hand2tm1Dsr/Hand2tm1Dsr
involves: 129S7/SvEvBrd * C57BL/6 		absent pharyngeal arches J:49658
congestive heart failure J:49658
decreased embryo size J:49658
embryonic growth retardation J:49658
embryonic lethality during organogenesis, complete penetrance J:49658
incomplete somite formation J:49658
increased apoptosis J:49658
pharyngeal arch hypoplasia J:49658
Hand2tm1Dsr/Hand2tm2.1Dsr
Isl1tm1(cre)Tmj/Isl1+
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:169213
embryonic lethality during organogenesis, complete penetrance J:169213
heart right ventricle hypoplasia J:169213
increased apoptosis J:169213
Hand2tm1Dsr/Hand2tm2.1Dsr
Tg(Mef2c-cre)#Blk/0
involves: 129 * 129S7/SvEvBrd * C57BL/6 		abnormal tricuspid valve morphology J:169213
decreased heart right ventricle size J:169213
embryonic lethality during organogenesis, complete penetrance J:169213
heart right ventricle hypoplasia J:169213
persistent truncus arteriosus J:169213
thin myocardium J:169213
ventricular septal defect J:169213
Hand2tm1Dsr/Hand2tm2.1Dsr
Tg(Nkx2-5-cre)9Eno/0
involves: 129 * 129S7/SvEvBrd * C57BL/6 		decreased heart left ventricle size J:169213
decreased heart right ventricle size J:169213
embryonic lethality during organogenesis, complete penetrance J:169213
Hand2tm1Dsr/Hand2tm2.1Dsr
Tg(Tbx1-cre)#Dsr/0
involves: 129 * 129S7/SvEvBrd * C57BL/6 		abnormal cardiac outflow tract development J:169213
decreased heart right ventricle size J:169213
lethality throughout fetal growth and development, complete penetrance J:169213
Hand2tm1Majh/Hand2tm1Majh
involves: 129S1/SvImJ 		abnormal craniofacial bone morphology J:137726
abnormal heart development J:137726
abnormal suckling behavior J:137726
cleft secondary palate J:137726
decreased embryo size J:137726
embryonic lethality during organogenesis, complete penetrance J:137726
normal nervous system phenotype J:137726
short mandible J:137726
Hand2tm2.1Dsr/Hand2tm2.1Dsr
involves: 129 * C57BL/6 		no abnormal phenotype detected J:169213
Hand2tm2Eno/Hand2tm2Eno
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal apical ectodermal ridge morphology J:146638
abnormal atrioventricular cushion morphology J:146638
abnormal cardiac outflow tract development J:146638
abnormal facial morphology J:146638
abnormal first pharyngeal arch morphology J:146638
abnormal heart left ventricle morphology J:146638
abnormal heart right ventricle morphology J:146638
abnormal interventricular septum morphology J:146638
abnormal jaw morphology J:146638
abnormal limb bud morphology J:146638
decreased heart right ventricle size J:146638
dilated heart left ventricle J:146638
embryonic lethality during organogenesis, complete penetrance J:146638
increased atrioventricular cushion size J:146638
Tg(Hand2)#Tshir/0
Not Specified 		abnormal pollex morphology J:198239
decreased lumbar vertebrae number J:198239
hemimelia J:198239
Tg(Prrx1-Hand2)1Eno/0
involves: C57BL/6 * CBA 		polydactyly J:80030
Tg(Prrx1-Hand2)2Eno/0
involves: C57BL/6 * CBA 		abnormal forelimb zeugopod morphology J:80030
abnormal hindlimb zeugopod morphology J:80030
abnormal limb bone morphology J:80030
polydactyly J:80030
short limbs J:80030
Tg(Prrx1-Hand2)3Eno/0
involves: C57BL/6 * CBA 		oligodactyly J:80030
polydactyly J:80030
short limbs J:80030
Tg(Prrx1-Hand2)4Eno/0
involves: C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:80030
Tg(Prrx1-Hand2)5Eno/0
involves: C57BL/6 * CBA 		abnormal forelimb zeugopod morphology J:80030
abnormal hindlimb zeugopod morphology J:80030
abnormal limb bone morphology J:80030
polydactyly J:80030
Tg(Prrx1-Hand2)6Eno/0
involves: C57BL/6 * CBA 		abnormal forelimb zeugopod morphology J:80030
abnormal hindlimb zeugopod morphology J:80030
abnormal limb bone morphology J:80030
polydactyly J:80030
Tg(Prrx1-Hand2)7Eno/0
involves: C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:80030
Tg(Prrx1-Hand2)8Eno/0
involves: C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:80030
Tg(Prrx1-Hand2/VP16)1Eno/0
involves: C57BL/6 * CBA 		polydactyly J:80030
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory