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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Musk
muscle, skeletal, receptor tyrosine kinase
MGI:103581
37 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Musktm1.1Vwi/Musktm1.1Vwi
involves: C57BL/6J 		neonatal lethality, complete penetrance J:106867
Musktm1.1Vwi/Musktm2Vwi
Not Specified 		abnormal axon extension J:141024
abnormal endplate potential J:141024
abnormal gait J:141024
abnormal innervation J:141024
abnormal miniature endplate potential J:141024
abnormal muscle electrophysiology J:141024
abnormal neuromuscular synapse morphology J:141024
abnormal spine curvature J:141024
decreased body weight J:141024
decreased grip strength J:141024
decreased skeletal muscle mass J:141024
impaired coordination J:141024
kyphosis J:141024
muscle weakness J:141024
premature death J:141024
thin diaphragm muscle J:141024
Musktm1.2Ics/Musktm1.2Ics
involves: BALB/cN * C57BL/6NTac 		abnormal axon extension J:221340
abnormal motor capabilities/coordination/movement J:221340
abnormal neurite morphology J:221340
abnormal neuromuscular synapse morphology J:221340
abnormal phrenic nerve innervation pattern to diaphragm J:221340
abnormal spine curvature J:221340
decreased body size J:221340
decreased body weight J:221340
decreased grip strength J:221340
increased muscle fatigability J:221340
kyphosis J:221340
postnatal lethality, incomplete penetrance J:221340
progressive muscle weakness J:221340
respiratory failure J:221340
Musktm1Gdy/Musktm1Gdy
involves: 129P2/OlaHsd * C57BL/6 		abnormal innervation pattern to muscle J:33132
abnormal motor neuron innervation pattern J:33132
abnormal neuromuscular synapse morphology J:33132
cyanosis J:33132
failure of neuromuscular synapse postsynaptic differentiation J:33132
failure of neuromuscular synapse presynaptic differentiation J:33132
neonatal lethality, complete penetrance J:33132
no spontaneous movement J:33132
respiratory failure J:33132
unresponsive to tactile stimuli J:33132
Musktm1Vwi/Musktm1.1Vwi
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6J * FVB 		abnormal neuromuscular synapse morphology J:106867
abnormal phrenic nerve innervation pattern to diaphragm J:106867
decreased grip strength J:106867
kyphosis J:106867
muscle weakness J:106867
premature death J:106867
weight loss J:106867
Musktm1Vwi/Musktm1Vwi
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6J * FVB 		abnormal neuromuscular synapse morphology J:106867
abnormal phrenic nerve innervation pattern to diaphragm J:106867
decreased grip strength J:106867
kyphosis J:106867
muscle weakness J:106867
premature death J:106867
weight loss J:106867
Musktm2Vwi/Musktm2Vwi
Not Specified 		normal behavior/neurological phenotype J:141024
normal growth/size/body region phenotype J:141024
normal mortality/aging J:141024
normal muscle phenotype J:141024
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory