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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pms2
PMS1 homolog2, mismatch repair system component
MGI:104288
28 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pms2tm1.1Sks/Pms2tm1.1Sks
involves: 129S4/SvJae * C57BL/6J 		normal reproductive system phenotype J:310354
Pms2tm1.1Wed/Pms2tm1.1Wed
involves: 129S6/SvEvTac * C57BL/6NCr 		abnormal class switch recombination J:162378
abnormal DNA repair J:162378
abnormal mismatch repair J:162378
increased adenocarcinoma incidence J:162378
increased B cell derived lymphoma incidence J:162378
increased hemangioma incidence J:162378
increased liver adenoma incidence J:162378
increased lymphoma incidence J:162378
increased sarcoma incidence J:162378
increased T cell derived lymphoma incidence J:162378
premature death J:162378
normal reproductive system phenotype J:162378
Pms2tm1Lisk/Pms2+
involves: 129S2/SvPas 		increased incidence of tumors by chemical induction J:61787
Pms2tm1Lisk/Pms2tm1Lisk
involves: 129S2/SvPas 		abnormal cell physiology J:125218
abnormal class switch recombination J:162378
abnormal DNA repair J:162378
abnormal mismatch repair J:162378
abnormal seminiferous tubule morphology J:162378
abnormal sperm head morphology J:162378
chromosomal instability J:125218
coiled sperm flagellum J:162378
decreased male germ cell number J:162378
increased B cell derived lymphoma incidence J:162378
increased carcinoma incidence J:125218
increased lymphoma incidence J:125218
increased sarcoma incidence J:125218
male infertility J:162378
premature death J:125218, J:162378
short sperm flagellum J:162378
small testis J:162378
teratozoospermia J:162378
Pms2tm1Lisk/Pms2tm1Lisk
involves: 129S2/SvPas * C57BL/6 		abnormal male meiosis J:27389
abnormal mismatch repair J:27389
abnormal sperm flagellum morphology J:27389
globozoospermia J:27389
increased lymphoma incidence J:27389
increased sarcoma incidence J:27389
male infertility J:27389
oligozoospermia J:27389
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Not Specified 		premature death J:204653
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory