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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptger4
prostaglandin E receptor 4 (subtype EP4)
MGI:104311
58 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptger4tm1.1Matb/Ptger4tm1.1Matb
involves: 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:92301
Ptger4tm1.1Matb/Ptger4tm1.1Matb
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * FVB/N 		abnormal cardiac muscle tissue morphology J:158439
abnormal heart echocardiography feature J:158439
abnormal myocardial fiber morphology J:158439
cardiac hypertrophy J:158439
cardiac interstitial fibrosis J:158439
decreased cardiac muscle contractility J:158439
decreased heart left ventricle posterior wall thickness J:158439
dilated cardiomyopathy J:158439
dilated heart left ventricle J:158439
heart inflammation J:158439
increased heart weight J:158439
Ptger4tm1.2Matb/Ptger4+
B6.129S6-Ptger4tm1.2Matb 		abnormal calcium ion homeostasis J:112753
Ptger4tm1.2Matb/Ptger4tm1.2Matb
B6.129S6-Ptger4tm1.2Matb 		abnormal calcium ion homeostasis J:112753
Ptger4tm1.2Matb/Ptger4tm1.2Matb
involves: 129S6/SvEvTac * C57BL/6 		patent ductus arteriosus J:92301
perinatal lethality J:92301
Ptger4tm1Bhk/Ptger4tm1Bhk
involves: 129P2/OlaHsd * 129S/SvEv 		abnormal capillary morphology J:44108
abnormal lung morphology J:44108
decreased pulmonary vascular resistance J:44108
increased lung weight J:44108
left-to-right shunt J:44108
liver vascular congestion J:44108
lung hemorrhage J:44108
lymphangiectasis J:44108
macrovesicular hepatic steatosis J:44108
microvesicular hepatic steatosis J:44108
patent ductus arteriosus J:44108
postnatal lethality, complete penetrance J:44108
pulmonary alveolar hemorrhage J:44108
pulmonary edema J:44108
pulmonary vascular congestion J:44108
Ptger4tm1Bhk/Ptger4tm1Bhk
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal circulating interleukin-6 level J:78964
abnormal circulating serum amyloid protein level J:78964
abnormal cytokine level J:78964
abnormal macrophage physiology J:78964
abnormal prostaglandin level J:78964
abnormal vascular regression J:44108
decreased susceptibility to induced arthritis J:78964
normal immune system phenotype J:78964
normal mortality/aging J:44108
rheumatoid arthritis J:78964
Ptger4tm1Matb/Ptger4tm1Matb
involves: 129S6/SvEvTac * C57BL/6 		neonatal lethality J:92301
patent ductus arteriosus J:92301
Ptger4tm1Sna/Ptger4tm1Sna
involves: 129P2/OlaHsd * C57BL/6 		abnormal Langerhans cell physiology J:83725
abnormal osteoclast differentiation J:63070
abnormal osteoclast physiology J:63070
abnormal pulmonary alveolus morphology J:47618
abnormal T cell activation J:83725
normal cardiovascular system phenotype J:92865
congestive heart failure J:47618
decreased interferon-gamma secretion J:83725
decreased survivor rate J:47618
decreased susceptibility to type IV hypersensitivity reaction J:83725
decreased T cell proliferation J:83725
dilated heart left ventricle J:47618
dilated pulmonary artery J:47618
normal homeostasis/metabolism phenotype J:70534, J:92865
normal immune system phenotype J:83725, J:197334
lethargy J:47618
pallor J:47618
patent ductus arteriosus J:47618
postnatal lethality J:47618
pulmonary vascular congestion J:47618
Ptger4tm1Sna/Ptger4tm1Sna
involves: 129P2/OlaHsd * C57BL/6Cr 		decreased incidence of tumors by chemical induction J:73944
preneoplasia J:73944
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory