Myo7a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Myo7a
myosin VIIA
MGI:104510

86 phenotypes from 21 alleles in 23 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Myo7a^26SB/Myo7a^26SB involves: BALB/cRl	abnormal hair cell morphology	J:49926
Myo7a^26SB/Myo7a^26SB involves: BALB/cRl	abnormal hearing physiology	J:49926
Myo7a^816SB/Myo7a^816SB involves: BALB/cRl	abnormal hair cell morphology	J:49926
Myo7a^816SB/Myo7a^816SB involves: BALB/cRl	abnormal hearing physiology	J:49926
Myo7a^816SB/Myo7a^816SB involves: BALB/cRl * 47BS/Rl	abnormal auditory summating potential	J:46373
	abnormal cochlear hair cell stereociliary bundle morphology	J:46373
	abnormal orientation of cochlear hair cell stereociliary bundles	J:46373
	absent cochlear microphonics	J:46373
Myo7a^3336SB/Myo7a^3336SB involves: BALB/cRl	abnormal hair cell morphology	J:49926
Myo7a^3336SB/Myo7a^3336SB involves: BALB/cRl	abnormal hearing physiology	J:49926
Myo7a^4494SB/Myo7a^4494SB involves: BALB/cRl	abnormal hair cell morphology	J:49926
Myo7a^4494SB/Myo7a^4494SB involves: BALB/cRl	abnormal hearing physiology	J:49926
Myo7a^4626SB/Myo7a⁺ involves: BALB/cRl * 47BS/Rl * CBA/Ca	abnormal cochlear nerve compound action potential	J:134369
	abnormal outer hair cell stereociliary bundle morphology	J:134369
	decreased cochlear outer hair cell number	J:134369
	decreased outer hair cell stereocilia number	J:134369
	impaired hearing	J:134369
	increased susceptibility to age-related hearing loss	J:134369
Myo7a^4626SB/Myo7a^4626SB involves: 129S7/SvEvBrd * BALB/cRl * C3H * C57BL/6J * CBA/Ca	abnormal cochlear hair cell stereociliary bundle morphology	J:132633
Myo7a^4626SB/Myo7a^4626SB involves: BALB/cRl	abnormal cochlear hair cell inter-stereocilial links morphology	J:135991
	abnormal cochlear outer hair cell morphology	J:158897
	abnormal inner hair cell stereociliary bundle morphology	J:135991
	abnormal orientation of cochlear hair cell stereociliary bundles	J:135991
	abnormal outer hair cell stereociliary bundle morphology	J:135991, J:158897
	absent cochlear hair bundle ankle links	J:135991
	cochlear outer hair cell degeneration	J:135991
	short cochlear outer hair cells	J:135991
Myo7a^4626SB/Myo7a^4626SB involves: BALB/cRl * 47BS/Rl * C3Hf/Rl * C57BL/10Rl * CBA/Ca	abnormal outer hair cell stereociliary bundle morphology	J:108877
Myo7a^dmbo2/Myo7a^dmbo2 involves: C57BL/6J	abnormal cochlear hair cell stereociliary bundle morphology	J:195666
	abnormal inner hair cell stereociliary bundle morphology	J:195666
	abnormal orientation of outer hair cell stereociliary bundles	J:195666
	abnormal vestibular hair cell stereociliary bundle morphology	J:195666
	decreased inner hair cell stereocilia number	J:195666
	normal hearing/vestibular/ear phenotype	J:195666
	impaired hearing	J:195666
	increased or absent threshold for auditory brainstem response	J:195666
Myo7a^ewaso/Myo7a⁺ involves: C57BL/6J	increased or absent threshold for auditory brainstem response	J:195666
Myo7a^ewaso/Myo7a^ewaso involves: C57BL/6J	abnormal cochlear basement membrane morphology	J:195666
	abnormal cochlear outer hair cell morphology	J:195666
	abnormal inner hair cell stereociliary bundle morphology	J:195666
	abnormal orientation of inner hair cell stereociliary bundles	J:195666
	abnormal vestibular hair cell stereociliary bundle morphology	J:195666
	circling	J:195666
	cochlear hair cell degeneration	J:195666
	decreased inner hair cell stereocilia number	J:195666
	decreased outer hair cell stereocilia number	J:195666
	decreased vestibular hair cell stereocilia number	J:195666
	fused inner hair cell stereocilia	J:195666
	normal hearing/vestibular/ear phenotype	J:195666
	impaired hearing	J:195666
	increased or absent threshold for auditory brainstem response	J:195666
	trunk curl	J:195666
Myo7a^Hdb/Myo7a⁺ C3HeB/FeJ-Myo7a^Hdb/Ieg	abnormal inner hair cell stereociliary bundle morphology	J:93998
	abnormal outer hair cell stereociliary bundle morphology	J:93998
	abnormal vestibular hair cell stereociliary bundle morphology	J:93998
	fused inner hair cell stereocilia	J:93998
	head bobbing	J:93998
	hyperactivity	J:93998
	increased cochlear nerve compound action potential	J:93998
Myo7a^Hdb/Myo7a^4626SB involves: BALB/c * 47BS/Rl * C3HeB/FeJ * CBA/Ca	abnormal inner hair cell stereociliary bundle morphology	J:93998
	abnormal outer hair cell stereociliary bundle morphology	J:93998
	fused inner hair cell stereocilia	J:93998
Myo7a^Hdb/Myo7a^Hdb C3HeB/FeJ-Myo7a^Hdb/Ieg	abnormal inner hair cell stereociliary bundle morphology	J:93998
	abnormal outer hair cell stereociliary bundle morphology	J:93998
	decreased inner hair cell stereocilia number	J:93998
	decreased outer hair cell stereocilia number	J:93998
	fused inner hair cell stereocilia	J:93998
	head bobbing	J:93998
	hyperactivity	J:93998
	increased cochlear nerve compound action potential	J:93998
Myo7a^m1Btlr/Myo7a^m1Btlr C57BL/6J-Myo7a^m1Btlr	circling	J:213050
	head tossing	J:213050
	hyperactivity	J:213050
Myo7a^mpc142H/Myo7a^mpc142H involves: BALB/c * C3H/HeH * C57BL/6J	abnormal inner ear vestibule morphology	J:234901
	deafness	J:234901
Myo7a^polka/Myo7a^polka involves: C57BL/6J	abnormal cochlear hair cell stereociliary bundle morphology	J:157102
	abnormal retina pigment epithelium morphology	J:157102
	absent distortion product otoacoustic emissions	J:157102
	circling	J:119820
	decreased startle reflex	J:119820
	impaired swimming	J:119820
	increased or absent threshold for auditory brainstem response	J:119820
	short cochlear hair cell stereocilia	J:157102
Myo7a^sh1-1R/Myo7a^sh1-1R involves: D7R75M	impaired balance	J:81149
Myo7a^sh1-6J/Myo7a^sh1-6J involves: C57BLKS/J	abnormal gait	J:17340
	deafness	J:17340
	decreased body size	J:17340
	head tossing	J:17340
	impaired swimming	J:17340
	male infertility	J:17340
	retropulsion	J:17340
Myo7a^sh1-7J/Myo7a^sh1-7J STOCK Myo7a^sh1-7J/J	circling	J:91063
	deafness	J:91063
	head shaking	J:91063
	head tilt	J:91063
Myo7a^sh1-7J/Myo7a^sh1-8J B6.Cg-Myo7a^sh1-7J Myo7a^sh1-8J	absent startle reflex	J:183898
Myo7a^sh1-7J/Myo7a^sh1-8J B6.Cg-Myo7a^sh1-7J Myo7a^sh1-8J	circling	J:183898
Myo7a^sh1-8J/Myo7a⁺ B6.Cg-Myo7a^sh1-8J/J	impaired hearing	J:183898
Myo7a^sh1-8J/Myo7a^sh1-8J B6.Cg-Myo7a^sh1-8J/J	abnormal cochlear hair cell stereociliary bundle morphology	J:183898
	abnormal parental behavior	J:77937
	abnormal vestibular hair cell stereociliary bundle morphology	J:183898
	circling	J:77937, J:183898
	head bobbing	J:77937
	increased or absent threshold for auditory brainstem response	J:183898
	normal pigmentation phenotype	J:141035
Myo7a^sh1-9J/Myo7a^sh1-9J involves: C3.MRL-Fas^lpr/J	circling	J:49039
Myo7a^sh1-9J/Myo7a^sh1-9J involves: C3.MRL-Fas^lpr/J	deafness	J:49039
Myo7a^sh1-11J/Myo7a^sh1-11J 129.B6-Myo7a^sh1-11J	abnormal retina rod cell morphology	J:181430
Myo7a^sh1-11J/Myo7a^sh1-11J 129.B6-Myo7a^sh1-11J	retina rod cell degeneration	J:181430
Myo7a^sh1-11J/Myo7a^sh1-11J C57BL/6J-Myo7a^sh1-11J/J	circling	J:82238
Myo7a^sh1-11J/Myo7a^sh1-11J C57BL/6J-Myo7a^sh1-11J/J	head tilt	J:82238
Myo7a^sh1-13J/Myo7a^sh1-13J C.Cg-Myo7a^sh1-13J/GrsrJ	abnormal gait	J:209272
	abnormal head movements	J:209272
	head bobbing	J:209272
	head shaking	J:209272
	head tossing	J:209272
	retropulsion	J:209272
	straub tail	J:209272
Myo7a^sh1/Myo7a^sh1 involves: BALB	abnormal behavior	J:15554
	abnormal cochlear hair cell morphology	J:14846
	abnormal cochlear OHC efferent innervation pattern	J:28477
	abnormal ear physiology	J:14858
	abnormal organ of Corti morphology	J:14846, J:28477
	absent pinna reflex	J:14858
	circling	J:15554, J:93998
	cochlear ganglion degeneration	J:13130, J:14846, J:14858, J:28477
	cochlear hair cell degeneration	J:13130, J:14858, J:93998
	deafness	J:14858, J:15554, J:93998
	gliosis	J:14891
	head tossing	J:93998
	hyperactivity	J:15554, J:93998
	impaired swimming	J:13130
	increased anxiety-related response	J:15554
	increased fluid intake	J:15554
	increased food intake	J:15554
	jerky movement	J:15554
	reduced male fertility	J:15554
	slow postnatal weight gain	J:15554
	stria vascularis degeneration	J:14858
	vestibular ganglion hypoplasia	J:13130
	vestibular saccular macula degeneration	J:13130
Myo7a^sh1/Myo7a^sh1 SH1/LeJ	absent linear vestibular evoked potential	J:116914
	circling	J:116914
	impaired swimming	J:116914
Myo7a^{tm1a(EUCOMM)Wtsi}/Myo7a^{tm1a(EUCOMM)Wtsi} C57BL/6N-Myo7a^{tm1a(EUCOMM)Wtsi}/Wtsi	absent pinna reflex	J:211773
	impaired righting response	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating sodium level	J:211773
	persistence of hyaloid vascular system	J:211773
	stereotypic behavior	J:211773
	trunk curl	J:211773
Myo7a^{tm1b(EUCOMM)Wtsi}/Myo7a⁺ B6J.Cg-Myo7a^{tm1b(EUCOMM)Wtsi}	abnormal electroretinogram waveform feature	J:283233
	cochlear ganglion degeneration	J:283233
	cochlear outer hair cell degeneration	J:283233
	decreased a-wave amplitude	J:283233
	decreased b-wave amplitude	J:283233
	increased or absent threshold for auditory brainstem response	J:283233
	sensorineural hearing loss	J:283233
Myo7a^{tm1b(EUCOMM)Wtsi}/Myo7a^{tm1b(EUCOMM)Wtsi} B6J.Cg-Myo7a^{tm1b(EUCOMM)Wtsi}	abnormal electroretinogram waveform feature	J:283233
	cochlear degeneration	J:283233
	cochlear ganglion degeneration	J:283233
	cochlear hair cell degeneration	J:283233
	deafness	J:283233
	decreased a-wave amplitude	J:283233
	decreased b-wave amplitude	J:283233
	head tilt	J:283233
	hyperactivity	J:283233
	impaired pupillary reflex	J:283233
	increased or absent threshold for auditory brainstem response	J:283233
	sensorineural hearing loss	J:283233
	spinning	J:283233
	thin stria vascularis	J:283233

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