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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
MGI:104511
33 phenotypes from 11 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Actb-Tnfsf4)1Nish/0
B6.D2-Tg(Actb-Tnfsf4)1Nish 		abnormal cytokine secretion J:80214
increased susceptibility to type IV hypersensitivity reaction J:80214
increased T cell proliferation J:80214
Tg(Lck-Tnfsf4)1Nish/0
B6.Cg-Tg(Lck-Tnfsf4)1Nish 		abnormal CD4-positive, alpha-beta T cell physiology J:194882
abnormal cytokine secretion J:80214
abnormal lung morphology J:194882
abnormal pulmonary artery morphology J:194882
abnormal T cell subpopulation ratio J:194882
heart right ventricle hypertrophy J:194882
increased CD4-positive, alpha-beta T cell number J:194882
increased interleukin-13 secretion J:194882
increased regulatory T cell number J:194882
increased right ventricle systolic pressure J:194882
increased susceptibility to type IV hypersensitivity reaction J:80214
increased T cell proliferation J:80214
increased vasoconstriction J:194882
lung inflammation J:194882
Tg(Lck-Tnfsf4)1Nish/0
C.Cg-Tg(Lck-Tnfsf4)1Nish 		abnormal CD4-positive, alpha-beta T cell physiology J:194882
normal cardiovascular system phenotype J:194882
increased CD4-positive, alpha-beta T cell number J:194882
increased interleukin-13 secretion J:194882
increased regulatory T cell number J:194882
normal respiratory system phenotype J:194882
Tg(Mt1-Tnfsf4)1Pgn/?
C57BL/6J-Tg(Mt1-Tnfsf4)1Pgn 		normal homeostasis/metabolism phenotype J:97460
increased susceptibility to atherosclerosis J:97460
Tg(Mt1-Tnfsf4)2Pgn/?
C57BL/6J-Tg(Mt1-Tnfsf4)2Pgn 		normal homeostasis/metabolism phenotype J:97460
increased susceptibility to atherosclerosis J:97460
Tnfsf4Ath1-BALB/cJ/?
involves: BALB/cJ * C57BL/6J 		decreased susceptibility to atherosclerosis J:8735
increased circulating HDL cholesterol level J:8735
Tnfsf4Ath1-C3H/HeJ/?
involves: C3H/HeJ * C57BL/6J 		increased circulating HDL cholesterol level J:9135
Tnfsf4Ath1-C57BL/6J/?
involves: BALB/cJ * C57BL/6J 		abnormal cardiovascular system morphology J:8735
abnormal lipid homeostasis J:8735
Tnfsf4Ath1-C57BL/6J/?
involves: C3H/HeJ * C57BL/6J 		decreased circulating HDL cholesterol level J:8735, J:9135
increased susceptibility to atherosclerosis J:8735
Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-C57BL/6J
B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn 		increased circulating HDL cholesterol level J:79722
Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn 		abnormal blood vessel morphology J:79722
increased circulating HDL cholesterol level J:79722
Tnfsf4Ath1-SPRET/EiJ/Tnfsf4Ath1-SPRET/EiJ
involves: C57BL/6J * SPRET/EiJ 		decreased susceptibility to atherosclerosis J:79722
Tnfsf4tm1Shr/Tnfsf4tm1Shr
C.129S4-Tnfsf4tm1Shr 		abnormal cytokine secretion J:59203
abnormal dendritic cell antigen presentation J:59203
Tnfsf4tm1Shr/Tnfsf4tm1Shr
involves: 129S4/SvJae 		abnormal cell-mediated immunity J:59203
abnormal dendritic cell antigen presentation J:59203
decreased interferon-gamma secretion J:59203
decreased interleukin-2 secretion J:59203
decreased interleukin-4 secretion J:59203
decreased susceptibility to type IV hypersensitivity reaction J:59203
decreased T cell proliferation J:59203
normal immune system phenotype J:59203
Tnfsf4tm1Shr/Tnfsf4tm1Shr
NOD.129S4-Tnfsf4tm1Shr 		decreased susceptibility to autoimmune diabetes J:86926
Tnfsf4tm1Sug/Tnfsf4tm1Sug
B6.129S4-Tnfsf4tm1Sug 		abnormal cytokine secretion J:80214
decreased susceptibility to type IV hypersensitivity reaction J:80214
decreased T cell proliferation J:80214
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory