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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
MGI:104512
52 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
B9d2/Tgfb1tm1Flv/B9d2+
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal enterocyte proliferation J:169839
abnormal T cell differentiation J:169839
cachexia J:169839
colitis J:169839
decreased susceptibility to experimental autoimmune encephalomyelitis J:169839
decreased T-helper 17 cell number J:169839
increased regulatory T cell number J:169839
increased T-helper 1 cell number J:169839
liver inflammation J:169839
lung inflammation J:169839
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal enterocyte proliferation J:169839
abnormal T cell differentiation J:169839
cachexia J:169839
colitis J:169839
decreased susceptibility to experimental autoimmune encephalomyelitis J:169839
decreased T-helper 17 cell number J:169839
increased regulatory T cell number J:169839
increased T-helper 1 cell number J:169839
liver inflammation J:169839
lung inflammation J:169839
Card11tm1.1Litt/Card11tm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal T cell activation J:180410
normal immune system phenotype J:180410
respiratory system inflammation J:180410
normal respiratory system phenotype J:180410
Cd4tm1Nik/Cd4tm1Nik
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ 		abnormal regulatory T cell physiology J:152472
Elavl1tm1.1Atas/Elavl1tm1.1Atas
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ * C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:207013
decreased T cell proliferation J:207013
decreased T-helper 17 cell number J:207013
Fyntm1Sor/Fyntm1Sor
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S7/SvEvBrd * 129X1/SvJ 		abnormal regulatory T cell physiology J:152472
decreased regulatory T cell number J:152472
decreased T cell proliferation J:152472
enlarged lymph nodes J:152472
increased regulatory T cell number J:152472
increased T cell number J:152472
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ 		abnormal regulatory T cell physiology J:152472
decreased regulatory T cell number J:152472
decreased T cell proliferation J:152472
enlarged lymph nodes J:152472
increased regulatory T cell number J:152472
increased T cell number J:152472
Nbr1tm1.1Jmos/Nbr1tm1.1Jmos
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ * C57BL/6J 		abnormal T-helper 1 cell differentiation J:165438
abnormal T-helper 2 cell differentiation J:165438
decreased inflammatory response J:165438
decreased interferon-gamma secretion J:165438
decreased interleukin-4 secretion J:165438
decreased interleukin-5 secretion J:165438
decreased interleukin-13 secretion J:165438
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
Rag2tm1Fwa/Rag2tm1Fwa
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal keratinocyte differentiation J:226194
dermatitis J:226194
epidermal hyperplasia J:226194
premature death J:226194
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129X1/SvJ * C57BL/6 		abnormal hypodermis fat layer morphology J:226194
abnormal keratinocyte differentiation J:226194
abnormal regulatory T cell number J:226194
abnormal T cell physiology J:226194
cachexia J:226194
dermatitis J:226194
enlarged lymph nodes J:226194
enlarged spleen J:226194
epidermal hyperplasia J:226194
hair follicle degeneration J:226194
hyperkeratosis J:226194
impaired skin barrier function J:226194
premature death J:226194
premature hair loss J:226194
scaly skin J:226194
skin fibrosis J:226194
skin hyperplasia J:226194
skin lesions J:226194
thick skin J:226194
Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal humoral immune response J:164283
decreased germinal center B cell number J:164283
decreased IgG1 level J:164283
decreased spleen germinal center number J:164283
decreased T follicular helper cell number J:164283
Ptentm2.1Ppp/Ptentm2.1Ppp
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S1/Sv * 129X1/SvJ 		increased germinal center B cell number J:164283
increased IgG1 level J:164283
increased T follicular helper cell number J:164283
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129 * C57BL/6 * NOD * SJL 		normal immune system phenotype J:196160
increased susceptibility to autoimmune diabetes J:196160
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11/12/2024
MGI 6.24 		The Jackson Laboratory