Xrcc5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
MGI:104517

80 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Xrcc5^{em1(IMPC)Ccpcz}/Xrcc5^{em1(IMPC)Ccpcz} C57BL/6NCrl-Xrcc5^{em1(IMPC)Ccpcz}/Ccpcz	abnormal cranium morphology	J:211773
	abnormal heart left ventricle morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal spine curvature	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal thymus morphology	J:211773
	abnormal vertebrae morphology	J:211773
	abnormal vertebral arch morphology	J:211773
	abnormal zygomatic bone morphology	J:211773
	aorta stenosis	J:211773
	decreased cardiac output	J:211773
	decreased cardiac stroke volume	J:211773
	decreased exploration in new environment	J:211773
	decreased grip strength	J:211773
	decreased heart left ventricle size	J:211773
	decreased hemoglobin content	J:211773
	decreased lean body mass	J:211773
	decreased leukocyte cell number	J:211773
	decreased locomotor activity	J:211773
	female infertility	J:211773
	hyperactivity	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating phosphate level	J:211773
	increased circulating triglyceride level	J:211773
	increased grip strength	J:211773
	increased heart weight	J:211773
	increased kidney weight	J:211773
	increased liver weight	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
	increased mean platelet volume	J:211773
	increased red blood cell distribution width	J:211773
	kyphosis	J:211773
	male infertility	J:211773
	scoliosis	J:211773
	short tibia	J:211773
	small spleen	J:211773
	small testis	J:211773
	small thymus	J:211773
	thin ventricular wall	J:211773
Xrcc5^m1Btlr/Xrcc5^m1Btlr C57BL/6J-Xrcc5^m1Btlr	abnormal B cell differentiation	J:274736
	abnormal CD8-positive, alpha-beta T cell differentiation	J:274736
	abnormal T cell differentiation	J:274736
	decreased B-2 B cell number	J:274736
	decreased CD4-positive, alpha-beta T cell number	J:274736
	decreased CD8-positive, alpha-beta T cell number	J:274736
	decreased CD8-positive, naive alpha-beta T cell number	J:274736
	decreased T cell number	J:274736
	increased B-1a cell number	J:274736
	increased B-1b cell number	J:274736
	increased CD4-positive, alpha-beta T cell number	J:274736
	increased dendritic cell number	J:274736
	increased effector memory CD4-positive, alpha-beta T cell number	J:274736
	increased effector memory CD8-positive, alpha-beta T cell number	J:274736
	increased neutrophil cell number	J:274736
Xrcc5^tm1Dbr/Xrcc5⁺ involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S1/Sv * C57BL/6	abnormal B cell differentiation	J:34834
	abnormal retina morphology	J:86825
	absent T cells	J:34834
	arrested B cell differentiation	J:34834
	arrested T cell differentiation	J:34834
	increased double-negative T cell number	J:34834
	increased retina apoptosis	J:86825
	lymph node hypoplasia	J:34834
	thymus hypoplasia	J:34834
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
	normal mortality/aging	J:80467
	prenatal lethality, incomplete penetrance	J:80467
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr Not Specified	increased neuron apoptosis	J:110848
Xrcc5^tm1Nus/Xrcc5^tm1Nus involves: 129S1/Sv * 129X1/SvJ	abnormal bone marrow cell morphology/development	J:108657
	abnormal class switch recombination	J:120658
	abnormal double-strand DNA break repair	J:108657
	abnormal humoral immune response	J:120658
	abnormal maternal nurturing	J:81484
	decreased body size	J:81484
	decreased litter size	J:81484
	fetal growth retardation	J:81484
	increased cellular sensitivity to ionizing radiation	J:108657
	postnatal lethality, incomplete penetrance	J:81484
	proportional dwarf	J:81484
	spleen hypoplasia	J:108657
	thymus hypoplasia	J:108657

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