Xrcc5 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
MGI:104517

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Nhej1^tm1Fwa/Nhej1^tm1Fwa Xrcc5^tm1Nus/Xrcc5^tm1Nus involves: 129S6/SvEvTac * C57BL/6	athymia	J:236776
	decreased body size	J:236776
	normal mortality/aging	J:236776
	small spleen	J:236776
Paxx^em1Spj/Paxx^em1Spj Xrcc5^tm1Nus/Xrcc5^tm1Nus involves: C57BL/6 * C57BL/6NTac	postnatal lethality, incomplete penetrance	J:236776
Rag1^tm1Mom/Rag1^tm1Mom Trp53^tm1Brd/Trp53^tm1Brd Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S7/SvEvBrd * C57BL	dehydration	J:141515
	impaired balance	J:141515
	increased medulloblastoma incidence	J:141515
	increased sarcoma incidence	J:141515
	increased stomach tumor incidence	J:141515
	increased T cell derived lymphoma incidence	J:141515
	premature death	J:141515
	respiratory distress	J:141515
Rag1^tm1Mom/Rag1^tm1Mom Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S7/SvEvBrd * C57BL	increased cerebellar granule cell number	J:141515
	normal neoplasm	J:141515
Trp53^tm1Brd/Trp53^tm1Brd Xrcc5^tm1Dbr/Xrcc5^tm1Dbr involves: 129S7/SvEvBrd * C57BL	increased lymphoma incidence	J:141515
	increased medulloblastoma incidence	J:141515
	premature death	J:141515
Xrcc5^tm1Dbr/Xrcc5⁺ Lig4^tm1Fwa/Lig4⁺ involves: 129S6/SvEvTac * C57BL/6	chromosome breakage	J:80467
Xrcc5^tm1Dbr/Xrcc5^tm1Dbr Lig4^tm1Fwa/Lig4^tm1Fwa involves: 129S6/SvEvTac * C57BL/6	abnormal lymphocyte morphology	J:80467
	abnormal small intestine morphology	J:80467
	chromosome breakage	J:80467
	normal mortality/aging	J:80467
	prenatal lethality, incomplete penetrance	J:80467

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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