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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Brca1
breast cancer 1, early onset
MGI:104537
108 phenotypes from 19 alleles in 33 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brca1tm1.1Brn/Brca1tm1.1Brn
involves: 129P2/OlaHsd * BALB/cJ * FVB/N 		prenatal lethality, complete penetrance J:126551
Brca1tm1.1Jjon/Brca1tm1.1Jjon
involves: C57BL/6J 		embryonic growth retardation J:178595
embryonic lethality during organogenesis, complete penetrance J:178595
Brca1tm1Aash/Brca1tm1Aash
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:119996
Brca1tm1Aash/Brca1tm1Aash
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		increased mammary gland tumor incidence J:119996
increased salivary adenocarcinoma incidence J:119996
Brca1tm1Arge/Brca1+
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:40594
Brca1tm1Arge/Brca1tm1Arge
involves: 129S/SvEv * C57BL/6 		abnormal egg cylinder morphology J:40594
abnormal embryonic tissue morphology J:40594
absent amniotic folds J:40594
absent mesoderm J:40594
embryonic growth retardation J:40594
embryonic lethality, complete penetrance J:40594
empty decidua capsularis J:40594
Brca1tm1Arge/Brca1tm1Arge
Tg(Hsp70-1-cre)1Arge/0
involves: 129S/SvEv * C57BL/6J * CBA 		embryonic lethality, complete penetrance J:134977
Brca1tm1Arge/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6J 		increased mammary adenocarcinoma incidence J:134977
Brca1tm1Bhk/Brca1+
C.129P2-Brca1tm1Bhk 		decreased body weight J:198018
decreased mammary gland epithelial cell proliferation J:198018
early cellular replicative senescence J:198018
increased mammary gland tumor incidence J:198018
Brca1tm1Bhk/Brca1+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		no abnormal phenotype detected J:31571
Brca1tm1Bhk/Brca1tm1Bhk
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:74077
open neural tube J:74077
Brca1tm1Bhk/Brca1tm1Bhk
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal embryonic neuroepithelial layer differentiation J:31571
decreased embryo size J:31571
embryonic lethality during organogenesis, complete penetrance J:31571
exencephaly J:31571
open neural tube J:31571
spina bifida J:31571
Brca1tm1Brn/Brca1tm1Brn
involves: 129P2/OlaHsd 		abnormal cell death J:117113
abnormal ovary morphology J:117113
decreased cell proliferation J:117113
Brca1tm1Brn/Brca1tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * BALB/cJ * FVB/N 		normal neoplasm J:126551
Brca1tm1Cxd/Brca1tm1Cxd
either: 129S6/SvEvTac-Brca1tm1Cxd or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal axial mesoderm morphology J:51834
abnormal chromosome number J:51834
abnormal embryonic tissue morphology J:51834
abnormal primitive streak formation J:51834
decreased embryo size J:51834
embryonic lethality between implantation and placentation, complete penetrance J:51834
increased cellular sensitivity to gamma-irradiation J:51834
Brca1tm1Cxd/Brca1tm1Cxd
involves: 129S6/SvEvTac 		abnormal double-strand DNA break repair J:269823
Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-cre)5132Jlj/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal epidermal layer morphology J:85354
increased keratinocyte proliferation J:85354
increased mouth tumor incidence J:85354
increased skin tumor incidence J:85354
increased squamous cell carcinoma incidence J:85354
increased tumor incidence J:85354
Brca1tm1Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB 		abnormal branching of the mammary ductal tree J:54533
abnormal involution of the mammary gland J:54533
abnormal mammary gland development J:54533
abnormal mammary gland growth during pregnancy J:54533
increased mammary adenocarcinoma incidence J:54533
increased mammary gland tumor incidence J:54533
Brca1tm1Cxd/Brca1tm2Cxd
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss 		abnormal branching of the mammary ductal tree J:54533
abnormal involution of the mammary gland J:54533
abnormal mammary gland development J:54533
abnormal mammary gland growth during pregnancy J:54533
increased mammary gland tumor incidence J:54533
Brca1tm1Mak/Brca1+
either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) 		no abnormal phenotype detected J:33880
Brca1tm1Mak/Brca1tm1Mak
either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) 		abnormal developmental patterning J:33880
abnormal embryonic tissue morphology J:33880
abnormal embryonic-extraembryonic boundary morphology J:33880
abnormal extraembryonic tissue morphology J:33880
abnormal parietal endoderm morphology J:33880
abnormal trophoblast layer morphology J:33880
abnormal visceral endoderm morphology J:33880
absent mesoderm J:33880
absent trophoblast giant cells J:33880
decreased embryo size J:33880
disorganized extraembryonic tissue J:33880
embryonic growth retardation J:33880
embryonic lethality between implantation and somite formation, complete penetrance J:33880
failure of primitive streak formation J:33880
Brca1tm1Rfo/Brca1tm1Rfo
involves: 129P2/OlaHsd 		abnormal developmental patterning J:69602
abnormal embryonic tissue morphology J:69602
abnormal heart development J:69602
embryonic growth retardation J:69602
embryonic lethality during organogenesis, complete penetrance J:67880
enlarged tail bud J:69602
incomplete somite formation J:69602
increased apoptosis J:69602
Brca1tm1Thl/Brca1tm1Thl
involves: 129 * C57BL/6J 		no abnormal phenotype detected J:134977
Brca1tm1Thl/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129S1/Sv * C57BL/6J 		increased mammary adenocarcinoma incidence J:134977
Brca1tm1Whl/Brca1+
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:34458
Brca1tm1Whl/Brca1tm1Whl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal developmental patterning J:34458
abnormal embryonic tissue morphology J:34458
absent egg cylinders J:34458
absent mesoderm J:34458
decreased cell proliferation J:34458
decreased embryo size J:34458
disorganized embryonic tissue J:34458
embryonic growth retardation J:34458
embryonic lethality between implantation and somite formation, complete penetrance J:34458
Brca1tm2.1Cxd/Brca1tm2.1Cxd
involves: 129S6/SvEvTac 		abnormal cell adhesion J:134494
abnormal cell death J:70271
abnormal cell migration J:134494
abnormal nervous system morphology J:70271
chromosomal instability J:307190
decreased embryo size J:70271
exencephaly J:70271
increased apoptosis J:70271
increased cellular sensitivity to gamma-irradiation J:81541
prenatal lethality, complete penetrance J:70271
Brca1tm2.1Cxd/Brca1tm2.1Cxd
involves: 129S6/SvEvTac * C57BL/6 		abnormal centrosome morphology J:177853
decreased fibroblast proliferation J:177853
early cellular replicative senescence J:177853
Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		normal neoplasm J:177853
Brca1tm2Arge/Brca1tm2Arge
129-Brca1tm2Arge 		abnormal skin pigmentation J:69187
arrest of spermatogenesis J:69187
increased mammary gland tumor incidence J:69187
increased tumor incidence J:69187
kinked tail J:69187
male infertility J:69187
postnatal growth retardation J:69187
Brca1tm2Arge/Brca1tm2Arge
B6.129-Brca1tm2Arge 		prenatal lethality, incomplete penetrance J:69187
Brca1tm2Arge/Brca1tm2Arge
involves: 129 		abnormal double-strand DNA break repair J:194229
increased susceptibility to xenobiotic induced morbidity/mortality J:194229
Brca1tm2Arge/Brca1tm2Arge
involves: 129 * C57BL/6 		increased tumor incidence J:177853
Brca1tm2Arge/Brca1tm2Arge
involves: 129 * C57BL/6J 		prenatal lethality, incomplete penetrance J:69187
Brca1tm2Arge/Brca1tm2Arge
involves: 129/Sv * C57BL/6J * MF1 		abnormal skin pigmentation J:69187
arrest of spermatogenesis J:69187
increased mammary gland tumor incidence J:69187
increased tumor incidence J:69187
kinked tail J:69187
male infertility J:69187
postnatal growth retardation J:69187
Brca1tm2Arge/Brca1tm3.1Rjbr
involves: 129 * C57BL/6 		normal neoplasm J:177853
Brca1tm2Cxd/Brca1tm2Cxd
involves: 129S6/SvEvTac * NIH Black Swiss 		no abnormal phenotype detected J:54533
Brca1tm2Cxd/Brca1tm2Cxd
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		chromosome breakage J:197442
Brca1tm2Cxd/Brca1tm2Cxd
Tg(Fshr-cre)1Ldu/0
involves: C57BL/6 * C57BL/6J * DBA/2 		kidney cyst J:97090
ovary cyst J:97090
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * C57BL/6 * FVB 		abnormal mammary gland duct morphology J:132088
increased mammary gland epithelial cell proliferation J:132088
increased mammary gland tumor incidence J:132088
mammary gland alveolar hyperplasia J:132088
ureter obstruction J:132088
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cell cycle checkpoint function J:63282
abnormal cell death J:63282
abnormal immune system organ morphology J:63282
abnormal T cell number J:63282
decreased double-positive T cell number J:63282
decreased single-positive T cell number J:63282
decreased T cell proliferation J:63282
decreased thymocyte number J:63282
increased cellular sensitivity to gamma-irradiation J:63282
increased double-negative T cell number J:63282
increased tumor incidence J:90512
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		increased mammary gland tumor incidence J:90512
Brca1tm2Rjbr/Brca1tm2Rjbr
involves: 129 		increased tumor incidence J:197743
Brca1tm2Rjbr/Brca1tm2Rjbr
involves: 129 * C57BL/6 		abnormal centrosome morphology J:177853
decreased fibroblast proliferation J:177853
early cellular replicative senescence J:177853
increased tumor incidence J:177853
male infertility J:177853
normal mortality/aging J:177853
Brca1tm3.1Rjbr/Brca1tm3.1Rjbr
involves: 129 * C57BL/6 		arrest of spermatogenesis J:177853
azoospermia J:177853
normal cellular phenotype J:177853
decreased body weight J:177853
male infertility J:177853
normal mortality/aging J:177853
normal neoplasm J:177853
small testis J:177853
Brca1tm4.1Rjbr/Brca1tm4.1Rjbr
involves: 129 * C57BL/6 		normal reproductive system phenotype J:177853
Brca1tm5.1Cxd/Brca1tm5.1Cxd
involves: 129S6/SvEvTac * FVB/N 		abnormal branching of the mammary ductal tree J:155810
abnormal coat/hair pigmentation J:155810
abnormal hair follicle morphology J:155810
abnormal hair growth J:155810
abnormal mammary gland development J:155810
abnormal mammary gland lobule morphology J:155810
abnormal small intestinal villus morphology J:155810
decreased body weight J:155810
decreased hair follicle number J:155810
decreased small intestinal villus height J:155810
decreased subcutaneous adipose tissue amount J:155810
decreased survivor rate J:155810
dermatitis J:155810
hyperactivity J:155810
increased cellular sensitivity to gamma-irradiation J:155810
increased incidence of tumors by ionizing radiation induction J:155810
increased liver tumor incidence J:155810
increased lymphoma incidence J:155810
increased mammary gland apoptosis J:155810
increased mammary gland epithelial cell proliferation J:155810
increased mammary gland tumor incidence J:155810
increased mortality induced by gamma-irradiation J:155810
increased T cell derived lymphoma incidence J:155810
mammary gland hyperplasia J:155810
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory