About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Brca1
breast cancer 1, early onset
MGI:104537
108 phenotypes from 19 alleles in 33 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Brca1tm1.1Brn/Brca1tm1.1Brn
involves: 129P2/OlaHsd * BALB/cJ * FVB/N 		prenatal lethality, complete penetrance J:126551
Brca1tm1.1Jjon/Brca1tm1.1Jjon
involves: C57BL/6J 		embryonic growth retardation J:178595
embryonic lethality during organogenesis, complete penetrance J:178595
Brca1tm1Aash/Brca1tm1Aash
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:119996
Brca1tm1Aash/Brca1tm1Aash
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		increased mammary gland tumor incidence J:119996
increased salivary adenocarcinoma incidence J:119996
Brca1tm1Arge/Brca1+
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:40594
Brca1tm1Arge/Brca1tm1Arge
involves: 129S/SvEv * C57BL/6 		abnormal egg cylinder morphology J:40594
abnormal embryonic tissue morphology J:40594
absent amniotic folds J:40594
absent mesoderm J:40594
embryonic growth retardation J:40594
embryonic lethality, complete penetrance J:40594
empty decidua capsularis J:40594
Brca1tm1Arge/Brca1tm1Arge
Tg(Hsp70-1-cre)1Arge/0
involves: 129S/SvEv * C57BL/6J * CBA 		embryonic lethality, complete penetrance J:134977
Brca1tm1Arge/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6J 		increased mammary adenocarcinoma incidence J:134977
Brca1tm1Bhk/Brca1+
C.129P2-Brca1tm1Bhk 		decreased body weight J:198018
decreased mammary gland epithelial cell proliferation J:198018
early cellular replicative senescence J:198018
increased mammary gland tumor incidence J:198018
Brca1tm1Bhk/Brca1+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		no abnormal phenotype detected J:31571
Brca1tm1Bhk/Brca1tm1Bhk
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:74077
open neural tube J:74077
Brca1tm1Bhk/Brca1tm1Bhk
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal embryonic neuroepithelial layer differentiation J:31571
decreased embryo size J:31571
embryonic lethality during organogenesis, complete penetrance J:31571
exencephaly J:31571
open neural tube J:31571
spina bifida J:31571
Brca1tm1Brn/Brca1tm1Brn
involves: 129P2/OlaHsd 		abnormal cell death J:117113
abnormal ovary morphology J:117113
decreased cell proliferation J:117113
Brca1tm1Brn/Brca1tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * BALB/cJ * FVB/N 		normal neoplasm J:126551
Brca1tm1Cxd/Brca1tm1Cxd
either: 129S6/SvEvTac-Brca1tm1Cxd or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal axial mesoderm morphology J:51834
abnormal chromosome number J:51834
abnormal embryonic tissue morphology J:51834
abnormal primitive streak formation J:51834
decreased embryo size J:51834
embryonic lethality between implantation and placentation, complete penetrance J:51834
increased cellular sensitivity to gamma-irradiation J:51834
Brca1tm1Cxd/Brca1tm1Cxd
involves: 129S6/SvEvTac 		abnormal double-strand DNA break repair J:269823
Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-cre)5132Jlj/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal epidermal layer morphology J:85354
increased keratinocyte proliferation J:85354
increased mouth tumor incidence J:85354
increased skin tumor incidence J:85354
increased squamous cell carcinoma incidence J:85354
increased tumor incidence J:85354
Brca1tm1Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * Black Swiss * FVB 		abnormal branching of the mammary ductal tree J:54533
abnormal involution of the mammary gland J:54533
abnormal mammary gland development J:54533
abnormal mammary gland growth during pregnancy J:54533
increased mammary adenocarcinoma incidence J:54533
increased mammary gland tumor incidence J:54533
Brca1tm1Cxd/Brca1tm2Cxd
Tg(Wap-cre)11738Mam/0
involves: 129S6/SvEvTac * Black Swiss 		abnormal branching of the mammary ductal tree J:54533
abnormal involution of the mammary gland J:54533
abnormal mammary gland development J:54533
abnormal mammary gland growth during pregnancy J:54533
increased mammary gland tumor incidence J:54533
Brca1tm1Mak/Brca1+
either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) 		no abnormal phenotype detected J:33880
Brca1tm1Mak/Brca1tm1Mak
either: (involves: 129P2/OlaHsd * C3H/HeJ) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1) 		abnormal developmental patterning J:33880
abnormal embryonic tissue morphology J:33880
abnormal embryonic-extraembryonic boundary morphology J:33880
abnormal extraembryonic tissue morphology J:33880
abnormal parietal endoderm morphology J:33880
abnormal trophoblast layer morphology J:33880
abnormal visceral endoderm morphology J:33880
absent mesoderm J:33880
absent trophoblast giant cells J:33880
decreased embryo size J:33880
disorganized extraembryonic tissue J:33880
embryonic growth retardation J:33880
embryonic lethality between implantation and somite formation, complete penetrance J:33880
failure of primitive streak formation J:33880
Brca1tm1Rfo/Brca1tm1Rfo
involves: 129P2/OlaHsd 		abnormal developmental patterning J:69602
abnormal embryonic tissue morphology J:69602
abnormal heart development J:69602
embryonic growth retardation J:69602
embryonic lethality during organogenesis, complete penetrance J:67880
enlarged tail bud J:69602
incomplete somite formation J:69602
increased apoptosis J:69602
Brca1tm1Thl/Brca1tm1Thl
involves: 129 * C57BL/6J 		no abnormal phenotype detected J:134977
Brca1tm1Thl/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129S1/Sv * C57BL/6J 		increased mammary adenocarcinoma incidence J:134977
Brca1tm1Whl/Brca1+
involves: 129P2/OlaHsd * C57BL/6J 		no abnormal phenotype detected J:34458
Brca1tm1Whl/Brca1tm1Whl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal developmental patterning J:34458
abnormal embryonic tissue morphology J:34458
absent egg cylinders J:34458
absent mesoderm J:34458
decreased cell proliferation J:34458
decreased embryo size J:34458
disorganized embryonic tissue J:34458
embryonic growth retardation J:34458
embryonic lethality between implantation and somite formation, complete penetrance J:34458
Brca1tm2.1Cxd/Brca1tm2.1Cxd
involves: 129S6/SvEvTac 		abnormal cell adhesion J:134494
abnormal cell death J:70271
abnormal cell migration J:134494
abnormal nervous system morphology J:70271
chromosomal instability J:307190
decreased embryo size J:70271
exencephaly J:70271
increased apoptosis J:70271
increased cellular sensitivity to gamma-irradiation J:81541
prenatal lethality, complete penetrance J:70271
Brca1tm2.1Cxd/Brca1tm2.1Cxd
involves: 129S6/SvEvTac * C57BL/6 		abnormal centrosome morphology J:177853
decreased fibroblast proliferation J:177853
early cellular replicative senescence J:177853
Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		normal neoplasm J:177853
Brca1tm2Arge/Brca1tm2Arge
129-Brca1tm2Arge 		abnormal skin pigmentation J:69187
arrest of spermatogenesis J:69187
increased mammary gland tumor incidence J:69187
increased tumor incidence J:69187
kinked tail J:69187
male infertility J:69187
postnatal growth retardation J:69187
Brca1tm2Arge/Brca1tm2Arge
B6.129-Brca1tm2Arge 		prenatal lethality, incomplete penetrance J:69187
Brca1tm2Arge/Brca1tm2Arge
involves: 129 		abnormal double-strand DNA break repair J:194229
increased susceptibility to xenobiotic induced morbidity/mortality J:194229
Brca1tm2Arge/Brca1tm2Arge
involves: 129 * C57BL/6 		increased tumor incidence J:177853
Brca1tm2Arge/Brca1tm2Arge
involves: 129 * C57BL/6J 		prenatal lethality, incomplete penetrance J:69187
Brca1tm2Arge/Brca1tm2Arge
involves: 129/Sv * C57BL/6J * MF1 		abnormal skin pigmentation J:69187
arrest of spermatogenesis J:69187
increased mammary gland tumor incidence J:69187
increased tumor incidence J:69187
kinked tail J:69187
male infertility J:69187
postnatal growth retardation J:69187
Brca1tm2Arge/Brca1tm3.1Rjbr
involves: 129 * C57BL/6 		normal neoplasm J:177853
Brca1tm2Cxd/Brca1tm2Cxd
involves: 129S6/SvEvTac * NIH Black Swiss 		no abnormal phenotype detected J:54533
Brca1tm2Cxd/Brca1tm2Cxd
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		chromosome breakage J:197442
Brca1tm2Cxd/Brca1tm2Cxd
Tg(Fshr-cre)1Ldu/0
involves: C57BL/6 * C57BL/6J * DBA/2 		kidney cyst J:97090
ovary cyst J:97090
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * C57BL/6 * FVB 		abnormal mammary gland duct morphology J:132088
increased mammary gland epithelial cell proliferation J:132088
increased mammary gland tumor incidence J:132088
mammary gland alveolar hyperplasia J:132088
ureter obstruction J:132088
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cell cycle checkpoint function J:63282
abnormal cell death J:63282
abnormal immune system organ morphology J:63282
abnormal T cell number J:63282
decreased double-positive T cell number J:63282
decreased single-positive T cell number J:63282
decreased T cell proliferation J:63282
decreased thymocyte number J:63282
increased cellular sensitivity to gamma-irradiation J:63282
increased double-negative T cell number J:63282
increased tumor incidence J:90512
Brca1tm2Mak/Brca1tm2Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		increased mammary gland tumor incidence J:90512
Brca1tm2Rjbr/Brca1tm2Rjbr
involves: 129 		increased tumor incidence J:197743
Brca1tm2Rjbr/Brca1tm2Rjbr
involves: 129 * C57BL/6 		abnormal centrosome morphology J:177853
decreased fibroblast proliferation J:177853
early cellular replicative senescence J:177853
increased tumor incidence J:177853
male infertility J:177853
normal mortality/aging J:177853
Brca1tm3.1Rjbr/Brca1tm3.1Rjbr
involves: 129 * C57BL/6 		arrest of spermatogenesis J:177853
azoospermia J:177853
normal cellular phenotype J:177853
decreased body weight J:177853
male infertility J:177853
normal mortality/aging J:177853
normal neoplasm J:177853
small testis J:177853
Brca1tm4.1Rjbr/Brca1tm4.1Rjbr
involves: 129 * C57BL/6 		normal reproductive system phenotype J:177853
Brca1tm5.1Cxd/Brca1tm5.1Cxd
involves: 129S6/SvEvTac * FVB/N 		abnormal branching of the mammary ductal tree J:155810
abnormal coat/hair pigmentation J:155810
abnormal hair follicle morphology J:155810
abnormal hair growth J:155810
abnormal mammary gland development J:155810
abnormal mammary gland lobule morphology J:155810
abnormal small intestinal villus morphology J:155810
decreased body weight J:155810
decreased hair follicle number J:155810
decreased small intestinal villus height J:155810
decreased subcutaneous adipose tissue amount J:155810
decreased survivor rate J:155810
dermatitis J:155810
hyperactivity J:155810
increased cellular sensitivity to gamma-irradiation J:155810
increased incidence of tumors by ionizing radiation induction J:155810
increased liver tumor incidence J:155810
increased lymphoma incidence J:155810
increased mammary gland apoptosis J:155810
increased mammary gland epithelial cell proliferation J:155810
increased mammary gland tumor incidence J:155810
increased mortality induced by gamma-irradiation J:155810
increased T cell derived lymphoma incidence J:155810
mammary gland hyperplasia J:155810
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory