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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Brca1
breast cancer 1, early onset
MGI:104537
115 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Bard1tm1Thl/Bard1tm1Thl
Brca1tm1Arge/Brca1tm1Arge
involves: 129S/SvEv * 129S1/Sv
abnormal developmental patterning J:84329
abnormal embryonic tissue morphology J:84329
prenatal lethality J:84329
Bard1tm2Thl/Bard1tm2Thl
Brca1tm1Thl/Brca1tm1Thl
Waptm1(cre)Arge/0
involves: 129/Sv * 129S1/Sv * C57BL/6J
increased mammary adenocarcinoma incidence J:134977
Brca1tm1Aash/Brca1tm1Aash
Trp53tm1Brd/Trp53+
Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA
abnormal mammary gland development J:119996
increased mammary gland ductal carcinoma incidence J:119996
increased mammary gland tumor incidence J:119996
increased salivary adenocarcinoma incidence J:119996
Brca1tm1Arge/Brca1tm1Arge
Brca2tm1Arge/Brca2tm1Arge
involves: 129S/SvEv * C57BL/6
abnormal embryonic tissue morphology J:40594
embryonic lethality, complete penetrance J:40594
Brca1tm1Arge/Brca1tm1Arge
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
embryonic growth retardation J:40594
prenatal lethality J:40594
Brca1tm1Bhk/Brca1+
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
C.129-Cdkn2ctm1Yxi Brca1tm1Bhk
abnormal mammary gland morphology J:198018
increased mammary adenocarcinoma incidence J:198018
increased mammary gland tumor incidence J:198018
increased metastatic potential J:198018
Brca1tm1Bhk/Brca1tm1Bhk
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
C.129-Cdkn2ctm1Yxi Brca1tm1Bhk
lethality throughout fetal growth and development, complete penetrance J:198018
Brca1tm1Brn/Brca1+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * BALB/cJ * FVB/N
increased mammary gland tumor incidence J:126551
Brca1tm1Brn/Brca1tm1.1Jjon
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal tumor morphology J:178595
abnormal tumor pathology J:178595
decreased mammary gland tumor incidence J:178595
decreased skin tumor incidence J:178595
decreased tumor latency J:178595
Brca1tm1Brn/Brca1tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
increased ovary tumor incidence J:189304
Brca1tm1Brn/Brca1tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
abnormal oviduct morphology J:189304
hemorrhagic ascites J:189304
increased carcinoma incidence J:189304
increased metastatic potential J:189304
increased ovarian carcinoma incidence J:189304
increased ovary tumor incidence J:189304
Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * BALB/cJ * FVB/N
increased mammary gland tumor incidence J:126551
Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd
increased cell proliferation J:117113
Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * BALB/cJ * FVB/N
increased mammary gland tumor incidence J:126551
Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
abnormal tumor morphology J:178595
abnormal tumor pathology J:178595
increased mammary gland tumor incidence J:178595
increased skin tumor incidence J:178595
increased tumor latency J:178595
Brca1tm1Cxd/Brca1tm1Cxd
Trp53tm1Brd/Trp53tm1Brd
involves: 129S6/SvEvTac * 129S7/SvEvBrd
abnormal chromosome number J:51834
abnormal embryonic tissue morphology J:51834
decreased embryo size J:51834
embryonic lethality during organogenesis, complete penetrance J:51834
spontaneous chromosome breakage J:51834
Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-cre)5132Jlj/0
Tg(KRT5-E2F1)2Dgj/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal epidermal layer morphology J:85354
decreased tumor latency J:85354
increased keratinocyte proliferation J:85354
increased skin tumor incidence J:85354
increased squamous cell carcinoma incidence J:85354
preweaning lethality, incomplete penetrance J:85354
Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-E2F1)2Dgj/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal epidermal layer morphology J:85354
increased keratinocyte proliferation J:85354
increased mouth tumor incidence J:85354
increased papilloma incidence J:85354
increased reproductive system tumor incidence J:85354
increased skin tumor incidence J:85354
increased squamous cell carcinoma incidence J:85354
increased tumor incidence J:85354
Brca1tm1Cxd/Brca1tm2Cxd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
increased mammary gland tumor incidence J:54533
Brca1tm1Mak/Brca1tm1Mak
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas
embryonic lethality during organogenesis, complete penetrance J:41254
Brca1tm1Mak/Brca1tm1Mak
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas
abnormal allantois morphology J:41254
abnormal visceral yolk sac morphology J:41254
decreased embryo size J:41254
embryonic growth retardation J:41254
embryonic lethality during organogenesis, complete penetrance J:41254
failure of initiation of embryo turning J:41254
Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * C57BL/6 * FVB/N
decreased tumor latency J:177853
Brca1tm1Thl/Brca1tm2Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * C57BL/6 * FVB/N
decreased tumor latency J:177853
Brca1tm1Thl/Brca1tm3.1Rjbr
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * C57BL/6 * FVB/N
decreased tumor latency J:177853
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Cdkn1atm1Led/Cdkn1atm1Led
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
neonatal lethality, complete penetrance J:81559
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Gadd45atm1Ajf/Gadd45atm1Ajf
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6
abnormal centrosome morphology J:91673
aneuploidy J:91673
embryonic growth retardation J:91673
exencephaly J:91673
prenatal lethality, complete penetrance J:91673
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Parp1tm1Zqw/Parp1tm1Zqw
involves: 129S2/SvPas * 129S6/SvEvTac
abnormal centrosome morphology J:139260
abnormal chromosome morphology J:139260
aneuploidy J:139260
decreased cell proliferation J:139260
decreased embryo size J:139260
decreased telomere length J:139260
exencephaly J:139260
lethality throughout fetal growth and development, complete penetrance J:139260
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Shld1em1Nus/Shld1em1Nus
involves: 129S6/SvEvTac * C57BL/6NCrl
abnormal class switch recombination J:307190
chromosomal instability J:307190
normal mortality/aging J:307190
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd
abnormal cell cycle checkpoint function J:70271
abnormal esophageal epithelium morphology J:122899
abnormal stomach epithelium morphology J:122899
normal endocrine/exocrine gland phenotype J:70271
enlarged thymus J:81541
increased carcinoma incidence J:122899
increased embryonic tissue cell apoptosis J:70271
increased fibroblast proliferation J:70271
increased incidence of tumors by chemical induction J:122899
increased mammary gland tumor incidence J:70271
increased susceptibility to xenobiotic induced morbidity/mortality J:122899
increased T cell derived lymphoma incidence J:81541
normal mortality/aging J:70271
premature death J:81541
respiratory distress J:81541
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
abnormal bone structure J:81559
abnormal male meiosis J:82308
abnormal spermatid morphology J:82308
abnormal spermatogenesis J:82308
abnormal trabecular bone morphology J:81559
arrest of male meiosis J:82308
azoospermia J:82308
decreased body weight J:81559
decreased cell proliferation J:81559
decreased compact bone thickness J:81559
decreased subcutaneous adipose tissue amount J:81559
decreased total body fat amount J:81559
delayed hair regrowth J:81559
impaired wound healing J:81559
increased male germ cell apoptosis J:82308
increased physiological sensitivity to xenobiotic J:81559
increased tumor incidence J:81559
kyphosis J:81559
meiotic nondisjunction J:82308
muscular atrophy J:81559
osteoporosis J:81559
premature aging J:81559
premature death J:81559
small testis J:82308
thin dermal layer J:81559
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53tm1Brd/Trp53tm1Brd
involves: 129S6/SvEvTac * 129S7/SvEvBrd
increased T cell derived lymphoma incidence J:81541
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
decreased tumor latency J:177853
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129 * 129S6/SvEvTac
abnormal class switch recombination J:307190
chromosomal instability J:307190
Brca1tm2.1Cxd/Brca1tm2Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
decreased tumor latency J:177853
Brca1tm2.1Cxd/Brca1tm3.1Rjbr
Trp53tm3Tyj/Trp53+
Waptm1(cre)Arge/Wap+
involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
increased tumor latency J:177853
Brca1tm2Cxd/Brca1+
Tg(KRT5-E2F1)2Dgj/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal epidermal layer morphology J:85354
increased keratinocyte proliferation J:85354
increased skin tumor incidence J:85354
increased squamous cell carcinoma incidence J:85354
increased tumor incidence J:85354
Brca1tm2Cxd/Brca1tm2Cxd
Pkmtm1.1Mgvh/Pkmtm1.1Mgvh
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
decreased tumor-free survival time J:205213
increased liver tumor incidence J:205213
increased mammary gland tumor incidence J:205213
increased metastatic potential J:205213
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
increased mammary gland tumor incidence J:132088
mammary gland alveolar hyperplasia J:132088
preneoplasia J:132088
Brca1tm2Cxd/Brca1tm2Cxd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)4Mam/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
increased mammary gland epithelial cell proliferation J:132088
increased mammary gland tumor incidence J:132088
mammary gland alveolar hyperplasia J:132088
preneoplasia J:132088
ureter obstruction J:132088
Brca1tm2Cxd/Brca1tm2Cxd
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S6/SvEvTac
normal cellular phenotype J:197442
Brca1tm2Mak/Brca1tm2Mak
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
decreased thymocyte number J:63282
normal immune system phenotype J:63282
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
normal cellular phenotype J:90512
chromosomal instability J:90512
normal immune system phenotype J:90512
increased T cell derived lymphoma incidence J:90512
Brca1tm2Mak/Brca1tm2Mak
Chek2tm1Mak/Chek2tm1Mak
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
increased mammary adenocarcinoma incidence J:90512
Brca1tm2Mak/Brca1tm2Mak
Tg(BCL2)36Wehi/?
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
chromosomal instability J:63282
normal immune system phenotype J:63282
spontaneous chromosome breakage J:63282
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Tg(TcrLCMV)327Sdz/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal T cell number J:63282
decreased double-positive T cell number J:63282
decreased T cell proliferation J:63282
decreased thymocyte number J:63282
increased double-negative T cell number J:63282
Brca1tm2Mak/Brca1tm2Mak
Tg(Lck-cre)548Jxm/?
Trp53tm1Brd/Trp53tm1Brd
involves: 129P2/OlaHsd * C57BL/6 * CBA
chromosomal instability J:63282
normal immune system phenotype J:63282
increased T cell derived lymphoma incidence J:90512
premature death J:90512
spontaneous chromosome breakage J:63282
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53+
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
increased mammary adenocarcinoma incidence J:90512
Brca1tm2Mak/Brca1tm2Mak
Trp53tm1Brd/Trp53tm1Brd
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
increased tumor incidence J:90512
Brca1tm3Cxd/Brca1tm3Cxd
involves: 129S6/SvEvTac * FVB/N
abnormal awl hair morphology J:94114
abnormal branching of the mammary ductal tree J:94114
abnormal cell cycle J:94114
abnormal ovary morphology J:94114
increased body weight J:94114
increased hepatoma incidence J:94114
increased incidence of tumors by ionizing radiation induction J:94114
increased lipoma incidence J:94114
increased lymphoma incidence J:94114
increased mammary gland tumor incidence J:94114
increased tumor incidence J:94114
uterus hyperplasia J:94114
Brca1tm4Cxd/Brca1tm4Cxd
involves: 129S6/SvEvTac * NIH Black Swiss
abnormal cell cycle J:112308
abnormal centrosome morphology J:112308
abnormal mammary gland duct morphology J:112308
abnormal mammary gland epithelium morphology J:112308
abnormal mammary gland morphology J:112308
abnormal uterine cervix squamous epithelium morphology J:112308
endometrium hyperplasia J:112308
increased mammary gland ductal carcinoma incidence J:112308
increased mammary gland tumor incidence J:112308
mammary gland duct hyperplasia J:112308
mammary gland hyperplasia J:112308
normal mortality/aging J:112308

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory