Mafb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mafb
MAF bZIP transcription factor B
MGI:104555

75 phenotypes from 11 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(CAG-Mafb,-tdTomato)Good}/Gt(ROSA)26Sor⁺ Tg(Neurog1-cre)1Jejo/0 involves: 129S4/SvJae * C57BL/6J * SJL/J	abnormal cochlear ganglion morphology	J:207904
	abnormal inner hair cell synaptic ribbon morphology	J:207904
	normal nervous system phenotype	J:207904
	postnatal lethality, incomplete penetrance	J:207904
Mafb^em1Hts/Mafb⁺ involves: C57BL/6J	no abnormal phenotype detected	J:296168
Mafb^em1Hts/Mafb^em1Hts involves: C57BL/6J	abnormal podocyte foot process morphology	J:296168
	abnormal podocyte morphology	J:296168
	abnormal renal glomerulus morphology	J:296168
	expanded mesangial matrix	J:296168
	postnatal lethality, complete penetrance	J:296168
Mafb^em1Staka/Mafb^em1Staka involves: C57BL/6J	abnormal renal tubule morphology	J:279108
	decreased body weight	J:279108
	glomerulosclerosis	J:279108
	increased urine microalbumin level	J:279108
	podocyte foot process effacement	J:279108
	podocyte microvillus transformation	J:279108
Mafb^kr/Mafb^kr CBA.Cg-Mafb^kr	abnormal cell cycle	J:5392
	abnormal cell cycle checkpoint function	J:5392
	abnormal endolymphatic duct morphology	J:5392
	abnormal otic vesicle development	J:5392
	abnormal semicircular canal morphology	J:5392
	absent endolymphatic duct	J:5392
	inner ear cyst	J:5392
Mafb^kr/Mafb^kr involves: C3H/HeJ * C57BL/6J * CBA/CaJ	abnormal hyoid bone greater horn morphology	J:4596
	abnormal pharyngeal arch development	J:4596
	abnormal rhombomere morphology	J:4596
	ectopic bone	J:4596
	ectopic pharyngeal arch	J:4596
Mafb^kr/Mafb^kr Not Specified	abnormal bony labyrinth	J:13001
	abnormal cochlear sensory epithelium morphology	J:13001
	abnormal hindbrain development	J:1490
	abnormal inner ear morphology	J:13001
	abnormal membranous labyrinth morphology	J:13001
	abnormal neural tube morphology	J:1490, J:13001
	abnormal otic capsule development	J:13001
	abnormal otic vesicle development	J:13001, J:15032
	abnormal rhombomere 4 morphology	J:1490, J:13001
	abnormal rhombomere 5 morphology	J:1490
	circling	J:15032
	head tossing	J:15032
	hyperactivity	J:15032
	inner ear cyst	J:15032
	reduced female fertility	J:15032
	reduced male fertility	J:15032
Mafb^m1Gsb/Mafb^m1Gsb B6.Cg-Mafb^m1Gsb	abnormal endocrine pancreas development	J:132598
Mafb^tm1.1Good/Mafb^tm1.1Good involves: 129S4/SvJae * C57BL/6 * SJL	no abnormal phenotype detected	J:207904
Mafb^tm1.1Good/Mafb^tm1Jeng Foxg1^tm1(cre)Skm/Foxg1⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	apnea	J:207904
	normal hearing/vestibular/ear phenotype	J:207904
	neonatal lethality, complete penetrance	J:207904
	normal nervous system phenotype	J:207904
Mafb^tm1.1Good/Mafb^tm1Jeng Tg(Neurog1-cre)1Jejo/0 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	abnormal cochlear ganglion morphology	J:207904
	abnormal inner hair cell synaptic ribbon morphology	J:207904
	normal hearing/vestibular/ear phenotype	J:207904
	increased or absent threshold for auditory brainstem response	J:207904
	normal mortality/aging	J:207904
	normal nervous system phenotype	J:207904
Mafb^tm1.1Mardu/Mafb^tm1.1Mardu involves: C57BL/6J	normal embryo phenotype	J:311539
	normal growth/size/body region phenotype	J:311539
	normal skeleton phenotype	J:311539
Mafb^tm1.2Good/Mafb⁺ Tg(Isl1-EGFP)1Slp/0 involves: 129S4/SvJae BALB/c * C57BL/6	abnormal abducens nerve morphology	J:237642
	abnormal innervation pattern to muscle	J:237642
Mafb^tm1.2Good/Mafb^tm1.2Good involves: 129S4/SvJae * C57BL/6 * SJL	abnormal kidney development	J:207904
	cyanosis	J:207904
	inner ear cyst	J:207904
	neonatal lethality, complete penetrance	J:207904
	respiratory distress	J:207904
Mafb^tm1.2Good/Mafb^tm1.2Good Tg(Isl1-EGFP)1Slp/0 involves: 129S4/SvJae BALB/c * C57BL/6	abnormal hindbrain morphology	J:237642
	abnormal innervation pattern to muscle	J:237642
	abnormal oculomotor nerve morphology	J:237642
	absent abducens nerve	J:237642
	fusion of glossopharyngeal and vagus nerve	J:237642
Mafb^tm1.2Mardu/Mafb^tm1.2Mardu involves: C57BL/6 * C57BL/6J * CBA	neonatal lethality, complete penetrance	J:311539
	normal skeleton phenotype	J:311539
Mafb^tm1Jeng/Mafb^tm1Jeng involves: 129P2/OlaHsd * C57BL/6J	abnormal kidney morphology	J:111415
	abnormal renal tubule morphology	J:111415
	anuria	J:111415
	decreased renal glomerulus number	J:111415
	fused podocyte foot processes	J:111415
	normal immune system phenotype	J:111415
	increased circulating creatinine level	J:111415
	increased renal tubule apoptosis	J:111415
	inner ear cyst	J:111415
	kidney cortex cyst	J:111415
	kidney hemorrhage	J:111415
	neonatal lethality, complete penetrance	J:111415
Mafb^tm1Mhs/Mafb^tm1Mhs involves: 129S1/Sv * 129X1/SvJ	abnormal brainstem morphology	J:85746
	abnormal breathing pattern	J:85746
	abnormal nervous system physiology	J:85746
	abnormal respiration	J:85746
	apnea	J:85746
	cyanosis	J:85746
	normal nervous system phenotype	J:85746
	perinatal lethality, complete penetrance	J:85746
	respiratory distress	J:85746
	respiratory failure	J:85746

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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