Cdkn1c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdkn1c
cyclin dependent kinase inhibitor 1C
MGI:104564

107 phenotypes from 6 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn1c^{tm1.1(KOMP)Vlcg}/Cdkn1c⁺ C57BL/6N-Cdkn1c^{tm1.1(KOMP)Vlcg}/MbpMmucd	edema	J:211773
Cdkn1c^{tm1.1(KOMP)Vlcg}/Cdkn1c^{tm1.1(KOMP)Vlcg} C57BL/6N-Cdkn1c^{tm1.1(KOMP)Vlcg}/MbpMmucd	edema	J:211773
Cdkn1c^{tm1.1(KOMP)Vlcg}/Cdkn1c^{tm1.1(KOMP)Vlcg} C57BL/6N-Cdkn1c^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
Cdkn1c^tm1Bbd/Cdkn1c⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal intestine morphology	J:40142
	abnormal suckling behavior	J:40142
	absent gastric milk in neonates	J:40142
	cleft palate	J:40142
	lethality throughout fetal growth and development, incomplete penetrance	J:40142
	neonatal lethality, incomplete penetrance	J:40142
	paternal imprinting	J:40142
	short limbs	J:40142
Cdkn1c^tm1Bbd/Cdkn1c^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal bone ossification	J:40142
	abnormal digestive system development	J:40142
	abnormal duodenum morphology	J:40142
	abnormal hard palate morphology	J:40142
	abnormal ileum morphology	J:40142
	abnormal intestine morphology	J:40142
	abnormal long bone epiphysis morphology	J:40142
	abnormal midbrain morphology	J:88146
	abnormal soft palate morphology	J:40142
	abnormal suckling behavior	J:40142
	absent gastric milk in neonates	J:40142
	absent jejunum	J:40142
	cleft palate	J:40142
	delayed endochondral bone ossification	J:40142
	increased midbrain apoptosis	J:88146
	lethality throughout fetal growth and development, incomplete penetrance	J:40142
	meteorism	J:40142
	neonatal lethality, incomplete penetrance	J:40142
	palatal shelves fail to meet at midline	J:40142
	short limbs	J:40142
Cdkn1c^tm1Bbd/Cdkn1c^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal craniofacial bone morphology	J:40142
	abnormal digestive system morphology	J:40142
	abnormal limb bone morphology	J:40142
	abnormal skeleton development	J:40142
	lethality throughout fetal growth and development, incomplete penetrance	J:40142
	neonatal lethality, incomplete penetrance	J:40142
Cdkn1c^tm1Kat/Cdkn1c⁺ involves: 129P2/OlaHsd	abnormal placenta labyrinth morphology	J:102331
	abnormal renal glomerulus morphology	J:102331
	abnormal renal tubule morphology	J:102331
	abnormal trophoblast giant cell morphology	J:102331
	cortical renal glomerulopathies	J:102331
	increased placenta weight	J:102331
	increased systemic arterial systolic blood pressure	J:102331
	increased urine protein level	J:102331
	thrombocytopenia	J:102331
Cdkn1c^tm1Kat/Cdkn1c⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal intestine morphology	J:61190
	abnormal kidney morphology	J:102331
	abnormal renal glomerulus morphology	J:102331
	cleft secondary palate	J:61190
	cyanosis	J:61190
	dysphagia	J:61190
	increased systemic arterial blood pressure	J:102331
	increased urine protein level	J:102331
	lethality throughout fetal growth and development, incomplete penetrance	J:61190
	neonatal lethality, incomplete penetrance	J:61190
	paternal imprinting	J:61190
	respiratory distress	J:61190
	short gestation period	J:61190
	thrombocytopenia	J:102331
Cdkn1c^tm1Kat/Cdkn1c⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal abdominal wall morphology	J:147145
	abnormal intestine morphology	J:147145
	abnormal kidney papilla morphology	J:147145
	abnormal lens development	J:147145
	abnormal long bone epiphyseal plate morphology	J:147145
	abnormal placenta morphology	J:147145
	abnormal rib morphology	J:147145
	abnormal vertebrae morphology	J:147145
	cataract	J:147145
	cleft palate	J:147145
	decreased length of long bones	J:147145
	delayed bone ossification	J:147145
	embryonic growth retardation	J:147145
	enlarged adrenal glands	J:147145
	neonatal lethality, incomplete penetrance	J:147145
	omphalocele	J:147145
	paternal imprinting	J:147145
	postnatal growth retardation	J:147145
	uterus atresia	J:147145
	uterus atrophy	J:147145
Cdkn1c^tm1Kat/Cdkn1c^tm1Kat involves: 129P2/OlaHsd	abnormal placenta labyrinth morphology	J:102331
	abnormal renal glomerulus morphology	J:102331
	abnormal renal tubule morphology	J:102331
	abnormal trophoblast giant cell morphology	J:102331
	cortical renal glomerulopathies	J:102331
	increased placenta weight	J:102331
	increased systemic arterial systolic blood pressure	J:102331
	increased urine protein level	J:102331
	thrombocytopenia	J:102331
Cdkn1c^tm1Kat/Cdkn1c^tm1Kat involves: 129P2/OlaHsd * C57BL/6	abnormal endochondral bone ossification	J:61190
	abnormal female reproductive system morphology	J:61190
	abnormal fertility/fecundity	J:61190
	abnormal gland morphology	J:61190
	abnormal humerus morphology	J:61190
	abnormal intestine morphology	J:61190
	abnormal intramembranous bone ossification	J:61190
	abnormal male reproductive system morphology	J:61190
	abnormal placenta labyrinth morphology	J:102331, J:102344
	abnormal prostate gland development	J:61190
	abnormal seminal vesicle development	J:61190
	abnormal spleen white pulp morphology	J:61190
	abnormal spongiotrophoblast layer morphology	J:102331, J:102344
	abnormal testis development	J:61190
	abnormal trophoblast giant cell morphology	J:102331
	abnormal uterus development	J:61190
	absent gastric milk in neonates	J:61190
	cleft secondary palate	J:61190
	cyanosis	J:61190
	decreased body size	J:61190
	decreased body weight	J:61190
	delayed sexual maturation	J:61190
	dysphagia	J:61190
	enlarged placenta	J:102344
	female infertility	J:61190
	hydrometra	J:61190
	increased atretic ovarian follicle number	J:61190
	increased placenta weight	J:102331
	lethality throughout fetal growth and development, incomplete penetrance	J:61190
	meteorism	J:61190
	neonatal lethality, incomplete penetrance	J:61190
	postnatal lethality, incomplete penetrance	J:61190
	respiratory distress	J:61190
	vagina atresia	J:61190
Cdkn1c^tm1Sje/Cdkn1c⁺ involves: 129 * C57BL/6	postnatal lethality, complete penetrance	J:108700
Cdkn1c^tm1Sje/Cdkn1c⁺ involves: 129S2/SvHsd * 129S7/SvEvBrd	abnormal brown adipose tissue morphology	J:232408
	abnormal interscapular fat pad morphology	J:232408
	decreased brown adipose tissue amount	J:232408
	neonatal lethality, complete penetrance	J:232408
Cdkn1c^tm1Sje/Cdkn1c⁺ involves: 129S7/SvEvBrd * C57BL/6	enlarged adrenal glands	J:40203
	lethality throughout fetal growth and development, incomplete penetrance	J:104004
	paternal imprinting	J:40203
	postnatal lethality, incomplete penetrance	J:40203
Cdkn1c^tm1Sje/Cdkn1c^tm1Sje either: (involves: 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * ICR)	abnormal lens epithelium morphology	J:63217
	abnormal retina morphology	J:63217
Cdkn1c^tm1Sje/Cdkn1c^tm1Sje involves: 129S7/SvEvBrd * C57BL/6	abnormal ileum morphology	J:40203
	abnormal jejunum morphology	J:40203
	abnormal kidney medulla development	J:40203
	abnormal long bone epiphysis morphology	J:40203
	abnormal long bone morphology	J:40203
	abnormal skeletal muscle morphology	J:40203
	decreased fetal size	J:40203
	decreased length of long bones	J:40203
	herniated abdominal wall	J:40203
	increased diameter of long bones	J:40203
	increased lens epithelium apoptosis	J:40203
	lens vacuoles	J:40203
	lethality throughout fetal growth and development, incomplete penetrance	J:40203
	meteorism	J:40203
	omphalocele	J:40203
	palatal shelves fail to meet at midline	J:40203
	postnatal lethality, complete penetrance	J:40203
	normal renal/urinary system phenotype	J:104004
	respiratory distress	J:40203
	small inner medullary pyramid	J:40203
	split sternum	J:40203
Cdkn1c^tm2.1Kei/Cdkn1c⁺ B6.129P2-Cdkn1c^tm2.1Kei	no abnormal phenotype detected	J:176209
Cdkn1c^tm2.1Kei/Cdkn1c⁺ Tg(EIIa-cre)C5379Lmgd/0 B6.Cg-Cdkn1c^tm2.1Kei Tg(EIIa-cre)C5379Lmgd	kidney papillary atrophy	J:176209
Cdkn1c^tm2.1Kei/Cdkn1c⁺ Tg(Mx1-cre)1Cgn/0 B6.Cg-Cdkn1c^tm2.1Kei Tg(Mx1-cre)1Cgn	abnormal hematopoietic stem cell physiology	J:176209
	decreased hematopoietic stem cell number	J:176209
Gt(ROSA)26Sor^{tm1(Cdkn1c)Jfpa}/Gt(ROSA)26Sor⁺ Myl2^tm1(cre)Krc/Myl2⁺ involves: 129S7/SvEvBrd * C57BL/6	abnormal heart left ventricle pressure	J:197451
	decreased myocardial infarct size	J:197451
	increased coronary flow rate	J:197451

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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