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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdkn1b
cyclin dependent kinase inhibitor 1B
MGI:104565
93 phenotypes from 9 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv 		abnormal prostate gland dorsolateral lobe morphology J:115443
abnormal prostate gland physiology J:115443
abnormal response/metabolism to endogenous compounds J:115443
abnormal tooth morphology J:102001
decreased circulating testosterone level J:115443
increased body weight J:118516
increased brain weight J:118516
increased brown adipose tissue amount J:118516
increased circulating cholesterol level J:118516
increased inguinal fat pad weight J:118516
increased kidney weight J:118516
increased lung adenocarcinoma incidence J:120835
increased ovary tumor incidence J:236161
increased parametrial fat pad weight J:118516
increased white fat cell number J:118516
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv * C57BL 		abnormal fetal cardiomyocyte proliferation J:57380
decreased myocardial fiber size J:57380
enlarged heart J:57380
heart hyperplasia J:57380
increased heart weight J:57380
increased myocardial fiber number J:57380
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv * C57BL/6 		abnormal corpus luteum morphology J:33401
abnormal pituitary intermediate lobe morphology J:50053
female infertility J:33401
increased body weight J:33401
increased pituitary gland tumor incidence J:50053
increased spleen weight J:33401
increased thymocyte number J:33401
increased thymus weight J:33401
pituitary intermediate lobe hyperplasia J:33401, J:50053
prolonged estrous cycle J:33401
prolonged estrus J:33401
Cdkn1btm1Jro/Cdkn1btm1Jro
involves: 129S4/SvJaeSor * C57BL/6 		decreased cell proliferation J:71780
decreased keratinocyte proliferation J:71780
decreased T cell proliferation J:71780
delayed wound healing J:71780
increased body weight J:71780
Cdkn1btm1Kin/Cdkn1btm1Kin
involves: 129P2/OlaHsd * C57BL/6 		abnormal eye electrophysiology J:33402
abnormal granulosa cell morphology J:33402
abnormal Muller cell morphology J:33402
abnormal ovarian follicle morphology J:33402
abnormal pituitary intermediate lobe morphology J:33402
abnormal retina outer limiting membrane morphology J:33402
abnormal retina photoreceptor morphology J:33402
abnormal retina pigment epithelium morphology J:33402
abnormal uterus morphology J:33402
absent corpus luteum J:33402
absent tertiary ovarian follicles J:33402
adrenal medulla hyperplasia J:33402
disorganized retina layers J:33402
endometrium hyperplasia J:33402
enlarged adrenal glands J:33402
enlarged ovary J:33402
enlarged prostate gland J:33402
enlarged spleen J:33402
enlarged testis J:33402
enlarged thymus J:33402
female infertility J:33402
impaired ovarian folliculogenesis J:33402
increased amacrine cell number J:33402
increased body size J:33402
increased body weight J:33402
increased pituitary adenoma incidence J:33402
increased pituitary gland weight J:33402
increased T cell number J:33402
pituitary intermediate lobe hyperplasia J:33402
testicular hyperplasia J:33402
thymus hyperplasia J:33402
Cdkn1btm1Mlf/Cdkn1b+
involves: 129S4/SvJaeSor 		increased incidence of tumors by chemical induction J:103819
Cdkn1btm1Mlf/Cdkn1b+
involves: 129S4/SvJaeSor * C57BL/6NHsd 		increased cochlear inner hair cell number J:53290
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129S4/SvJaeSor 		abnormal neuron differentiation J:109091
enlarged spleen J:107588
enlarged thymus J:107588
impaired neuronal migration J:109091
increased incidence of tumors by chemical induction J:103819
spleen hypoplasia J:107588
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal cerebral cortex morphology J:33400
abnormal definitive hematopoiesis J:33400
abnormal epithalamus morphology J:33400
abnormal hepatocyte morphology J:33400
abnormal hippocampus morphology J:33400
abnormal retina neuronal layer morphology J:33400
abnormal spleen morphology J:33400
abnormal thymus morphology J:33400
absent corpus luteum J:33400
disorganized retina layers J:33400
enlarged pituitary gland J:33400
enlarged spleen J:33400
enlarged thymus J:33400
female infertility J:33400
increased body weight J:33400
increased pituitary adenoma incidence J:33400
increased T cell proliferation J:33400
pituitary gland hyperplasia J:33400
premature death J:33400
spleen hyperplasia J:33400
thymus hyperplasia J:33400
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129S4/SvJaeSor * C57BL/6NHsd 		abnormal cell proliferation J:53290
abnormal organ of Corti morphology J:53290
abnormal pillar cell morphology J:53290
normal behavior/neurological phenotype J:53290
impaired hearing J:53290
increased body size J:53290
increased cochlear hair cell number J:53290
increased cochlear inner hair cell number J:53290
increased cochlear outer hair cell number J:53290
increased or absent threshold for auditory brainstem response J:53290
increased organ of Corti supporting cell number J:53290
Cdkn1btm2.1Mlf/Cdkn1btm2.1Mlf
involves: 129S4/SvJaeSor 		premature death J:107588
Cdkn1btm2Jro/Cdkn1btm2Jro
involves: 129S4/SvJaeSor * C57BL/6 		decreased incidence of tumors by chemical induction J:103819
Cdkn1btm2Mlf/Cdkn1btm2Mlf
Tg(Pomc1-cre)1Mlf/0
involves: 129S4/SvJaeSor 		increased pituitary gland tumor incidence J:107588
premature death J:107588
Cdkn1btm3Mlf/Cdkn1btm3Mlf
involves: 129S4/SvJaeSor 		increased body size J:107588
increased pituitary gland tumor incidence J:107588
premature death J:107588
Cdkn1btm3Mlf/Cdkn1btm3Mlf
Tg(Pomc1-cre)1Mlf/0
involves: 129S4/SvJaeSor 		decreased tumor incidence J:107588
premature death J:107588
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory