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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdkn1b
cyclin dependent kinase inhibitor 1B
MGI:104565
127 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccnd1tm1Dsn/Ccnd1tm1Dsn
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129 * C57BL/6 		abnormal corpus luteum morphology J:66707
abnormal reflex J:66707
normal craniofacial phenotype J:66707
disorganized retina layers J:66707
normal endocrine/exocrine gland phenotype J:66707
enlarged spleen J:66707
enlarged testis J:66707
enlarged thymus J:66707
female infertility J:66707
increased body weight J:66707
increased pituitary adenoma incidence J:66707
normal mortality/aging J:66707
thymus hyperplasia J:66707
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129S4/SvJaeSor 		abnormal bone marrow cell physiology J:192031
decreased double-positive T cell number J:192031
decreased T cell proliferation J:192031
thymus hypoplasia J:192031
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Rb1tm2Brn/Rb1tm2Brn
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA 		normal immune system phenotype J:192031
Cdk2tm1Kald/Cdk2tm1Kald
Cdk4tm1Kiyo/Cdk4tm1Kiyo
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv * C57BL/6 		decreased cell proliferation J:108720
lethality throughout fetal growth and development, complete penetrance J:108720
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv * 129S2/SvPas 		abnormal junctional epithelium morphology J:102001
decreased circulating testosterone level J:115443
decreased prostate gland anterior lobe weight J:115443
decreased prostate gland dorsolateral lobe weight J:115443
decreased prostate gland ventral lobe weight J:115443
decreased seminal vesicle weight J:115443
hepatic steatosis J:118516
impaired glucose tolerance J:118516
increased body weight J:115443, J:118516
increased brain weight J:118516
increased brown adipose tissue amount J:118516
increased circulating cholesterol level J:118516
increased food intake J:118516
increased inguinal fat pad weight J:118516
increased kidney weight J:118516
increased lean body mass J:118516
increased parametrial fat pad weight J:118516
increased total body fat amount J:118516
increased white fat cell number J:118516
insulin resistance J:118516
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129S2/SvPas * 129S4/SvJaeSor 		abnormal crypts of Lieberkuhn morphology J:111081
abnormal enterocyte proliferation J:111081
abnormal ileum morphology J:111081
abnormal response to injury J:111081
abnormal small intestinal villus morphology J:111081
Cdkn1btm1Ako/Cdkn1b+
KitW-v/KitW-v
involves: 129S1/Sv * C57BL/6J 		abnormal ovary physiology J:236161
increased ovary adenoma incidence J:236161
increased ovary tumor incidence J:236161
premature death J:236161
Cdkn1btm1Ako/Cdkn1b+
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0
129S1.Cg-Cdkn1btm1Ako Tg(TPO-cre)1Shk Ptentm2.1Ppp 		increased thyroid adenoma incidence J:165293
increased thyroid carcinoma incidence J:165293
premature death J:165293
Cdkn1btm1Ako/Cdkn1btm1Ako
Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2 		ataxia J:50053
decreased tumor-free survival time J:50053
dehydration J:50053
enlarged adrenal glands J:50053
enlarged heart J:50053
enlarged pituitary gland J:50053
enlarged spleen J:50053
enlarged testis J:50053
enlarged thymus J:50053
increased carcinoma incidence J:50053
increased pituitary adenoma incidence J:50053
pituitary intermediate lobe hyperplasia J:50053
weight loss J:50053
Cdkn1btm1Ako/Cdkn1btm1Ako
KitW-v/KitW-v
involves: 129S1/Sv * C57BL/6J 		abnormal ovary physiology J:236161
increased ovary adenoma incidence J:236161
increased ovary tumor incidence J:236161
Cdkn1btm1Ako/Cdkn1btm1Ako
Men1tm1.1Ctre/Men1+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		increased adrenal gland tumor incidence J:120835
increased lung adenoma incidence J:120835
increased pancreas tumor incidence J:120835
increased parathyroid gland tumor incidence J:120835
increased pituitary gland tumor incidence J:120835
increased testis tumor incidence J:120835
increased thyroid tumor incidence J:120835
increased tumor incidence J:120835
Cdkn1btm1Ako/Cdkn1btm1Ako
Men1tm1.1Ctre/Men1tm1.1Ctre
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 		embryonic lethality, complete penetrance J:120835
Cdkn1btm1Ako/Cdkn1btm1Ako
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(TPO-cre)1Shk/0
129S1.Cg-Cdkn1btm1Ako Tg(TPO-cre)1Shk Ptentm2.1Ppp 		premature death J:165293
respiratory distress J:165293
thyroid gland hyperplasia J:165293
Cdkn1btm1Jro/Cdkn1btm1Jro
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CD-1 * FVB/N 		abnormal tumor pathology J:318035
decreased tumor growth/size J:318035
normal growth/size/body region phenotype J:318035
increased osteosarcoma incidence J:318035
increased tumor-free survival time J:318035
normal reproductive system phenotype J:318035
Cdkn1btm1Kin/Cdkn1b+
Leprdb/Leprdb
involves: C57BL/6J * C57BLKS/J 		abnormal pancreatic islet morphology J:96047
decreased body temperature J:96047
hyperglycemia J:96047
hyperlipidemia J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
obese J:96047
polyphagia J:96047
Cdkn1btm1Kin/Cdkn1b+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		enlarged pancreatic islets J:96047
increased circulating glucose level J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
Cdkn1btm1Kin/Cdkn1btm1Kin
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		enlarged pancreatic islets J:96047
increased circulating glucose level J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
Cdkn1btm1Kin/Cdkn1btm1Kin
Leprdb/Leprdb
involves: C57BL/6J * C57BLKS/J 		abnormal pancreatic islet morphology J:96047
decreased body temperature J:96047
hyperlipidemia J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
obese J:96047
polyphagia J:96047
Cdkn1btm1Kin/Cdkn1btm1Kin
Skp2tm1Kin/Skp2tm1Kin
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:74265
Cdkn1btm1Kin/Cdkn1btm1Kin
Zfp949tm1Htno/Zfp949tm1Htno
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal embryo turning J:259302
decreased cell proliferation J:259302
decreased embryo size J:259302
embryonic lethality during organogenesis, complete penetrance J:259302
Cdkn1btm1Mlf/Cdkn1b+
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
hydrocephaly J:205254
increased gastrointestinal tumor incidence J:205254
increased hemangiosarcoma incidence J:205254
increased lymphoma incidence J:205254
increased medulloblastoma incidence J:205254
increased rhabdomyosarcoma incidence J:205254
increased tumor incidence J:205254
premature death J:205254
Cdkn1btm1Mlf/Cdkn1b+
Myctm1Atp/Myc+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N 		decreased body size J:73369
Cdkn1btm1Mlf/Cdkn1b+
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
involves: 129 * C57BL/6 * CBA * FVB 		increased T cell derived lymphoma incidence J:88323
Cdkn1btm1Mlf/Cdkn1b+
Vsx2tm1.1Eml/Vsx2tm1.1Eml
involves: 129 * C57BL/6 		abnormal eye morphology J:190452
Cdkn1btm1Mlf/Cdkn1b+
Tg(TG-TPR/NTRK1)#Rstn/0
involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J 		increased thyroid carcinoma incidence J:210015
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Cdkn2dtm1Maro/Cdkn2dtm1Maro
involves: 129X1/SvJ * C57BL/6 		abnormal behavior J:58522
abnormal mitosis J:58522
abnormal neuron morphology J:58522
bradykinesia J:58522
cachexia J:58522
decreased body size J:58522
dehydration J:58522
impaired righting response J:58522
increased cell proliferation J:58522
increased mitotic index J:58522
increased neuron apoptosis J:58522
limb grasping J:58522
muscle hypertonia J:58522
normal nervous system phenotype J:58522
paresis J:58522
photosensitivity J:58522
postnatal lethality, complete penetrance J:58522
respiratory distress J:58522
seizures J:58522
tremors J:58522
weight loss J:58522
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Myctm1Atp/Myc+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N 		decreased body size J:73369
decreased T cell proliferation J:73369
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Myctm1Atp/Myctm1Atp
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N 		prenatal lethality, complete penetrance J:73369
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		increased prostate intraepithelial neoplasia incidence J:89571
preneoplasia J:89571
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
hydrocephaly J:205254
increased gastrointestinal tumor incidence J:205254
increased hemangiosarcoma incidence J:205254
increased lymphoma incidence J:205254
increased medulloblastoma incidence J:205254
increased rhabdomyosarcoma incidence J:205254
increased tumor incidence J:205254
premature death J:205254
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Rbx1Gt(XB674)Byg/Rbx1Gt(XB674)Byg
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J 		normal cellular phenotype J:147759
embryonic lethality during organogenesis, complete penetrance J:147759
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Tg(KRT5-CDK4)2303Mlrp/0
involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN 		enlarged thymus J:107588
thymus hyperplasia J:107588
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Tg(MMTV-vHaras)SH1Led/0
involves: 129S4/SvJaeSor * C57BL/6J * CD-1 		increased tumor growth/size J:80271
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Tg(TG-TPR/NTRK1)#Rstn/0
involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J 		increased thyroid carcinoma incidence J:210015
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Trp53tm1Brd/Trp53tm1Brd
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J 		decreased tumor-free survival time J:87536
increased sarcoma incidence J:87536
increased T cell derived lymphoma incidence J:87536
increased tumor incidence J:87536
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Trp53tm1Brd/Trp53tm1Brd
involves: C3H * C57BL/6J * NIH 		decreased tumor-free survival time J:87536
increased sarcoma incidence J:87536
increased T cell derived lymphoma incidence J:87536
increased tumor incidence J:87536
Cdkn1btm2Kin/Cdkn1btm2Kin
Rassf5tm1Kina/Rassf5tm1Kina
involves: C57BL/6 * CBA 		normal immune system phenotype J:168749
increased urine protein level J:168749
normal neoplasm J:168749
Cdkn1btm3Jro/Cdkn1b+
involves: 129S4/SvJaeSor 		increased body size J:103819
Cdkn1btm3Jro/Cdkn1btm3Jro
involves: 129S4/SvJaeSor 		enlarged spleen J:103819
enlarged thymus J:103819
increased body size J:103819
increased body weight J:103819
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
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11/12/2024
MGI 6.24 		The Jackson Laboratory