Procr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Procr
protein C receptor, endothelial
MGI:104596

32 phenotypes from 7 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Meox2^tm1(cre)Sor/Meox2⁺ Procr^tm1Cte/Procr^tm2Cte involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6	prenatal lethality, complete penetrance	J:119529
Meox2^tm1(cre)Sor/Meox2⁺ Procr^tm2Cte/Procr^tm2Cte involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Black Swiss * C57BL/6	abnormal hematopoietic system morphology/development	J:119529
	decreased circulating fibrinogen level	J:119529
	increased circulating C-reactive protein level	J:119529
	thrombocytopenia	J:119529
Procr^{tm1.1(cre/ERT2)Yaz}/Procr^{tm1.1(cre/ERT2)Yaz} involves: 129P2/OlaHsd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:217483
Procr^tm1.1Pcl/Procr⁺ involves: 129S2/SvPas * C57BL/6	abnormal circulating protein level	J:225914
Procr^tm1.1Pcl/Procr^tm1.1Pcl involves: 129S2/SvPas * C57BL/6	abnormal circulating protein level	J:225914
	bone marrow failure	J:225914
	decreased bone marrow cell number	J:225914
	enlarged spleen	J:225914
	extramedullary hematopoiesis	J:225914
	normal hematopoietic system phenotype	J:225914
	increased circulating interleukin-6 level	J:225914
	increased spleen red pulp amount	J:225914
	increased spleen weight	J:225914
	increased splenocyte number	J:225914
	increased susceptibility to endotoxin shock	J:225914
	increased susceptibility to induced thrombosis	J:225914
	normal mortality/aging	J:225914
	thrombocytopenia	J:225914
Procr^tm1Cte/Procr⁺ B6.129S7-Procr^tm1Cte	abnormal blood coagulation	J:144388
Procr^tm1Cte/Procr⁺ B6.129S7-Procr^tm1Cte	thrombocytopenia	J:144388
Procr^tm1Cte/Procr^tm1Cte either: 129S/SvEv-Procr^tm1Cte or (involves: 129S7/SvEvBrd * Black Swiss)	abnormal blood coagulation	J:80043
	abnormal extraembryonic tissue morphology	J:80043
	abnormal placental thrombosis	J:80043
	decreased embryo size	J:80043
	embryonic growth retardation	J:80043
	embryonic lethality during organogenesis, complete penetrance	J:80043
	incomplete embryo turning	J:80043
Procr^tm1Cte/Procr^tm1Cte involves: 129S7/SvEvBrd	prenatal lethality, incomplete penetrance	J:119529
Procr^tm1Cte/Procr^tm1Cte Tg(Tek-Procr)1Cte/0 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:119529
Procr^tm1Fjc/Procr^tm1Fjc involves: 129X1/SvJ	no abnormal phenotype detected	J:80955
Procr^tm2Cte/Procr^tm3Cte Meox2^tm1(cre)Sor/Meox2⁺ involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	normal mortality/aging	J:144388
Procr^tm3Cte/Procr^tm3Cte involves: 129S7/SvEvBrd * C57BL/6	prenatal lethality, complete penetrance	J:144388
Tg(Tek-Procr)1Cte/0 B6.FVB-Tg(Tek-Procr)1Cte	abnormal acute phase protein level	J:119637
	abnormal blood coagulation	J:119637
	abnormal enzyme/coenzyme level	J:119637
	abnormal immune system physiology	J:119637
	abnormal inflammatory response	J:119637
	abnormal platelet physiology	J:119637

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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