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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnnt2
troponin T2, cardiac
MGI:104597
62 phenotypes from 12 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tg(Myh6-Tnnt2)117Lnwd/0
involves: C57BL/6 		abnormal cardiac muscle relaxation J:48301
abnormal cardiovascular system physiology J:48301
abnormal heart atrium morphology J:48301
abnormal myocardial fiber morphology J:48301, J:56911
abnormal myocardial fiber physiology J:48301
abnormal Z line morphology J:56911
decreased cardiac muscle contractility J:48301
decreased heart left ventricle weight J:48301
decreased heart weight J:48301
decreased myocardial fiber number J:48301
decreased myocardial fiber size J:48301
disorganized myocardium J:48301
myocardial fiber degeneration J:48301, J:56911
Tg(Myh6-Tnnt2)117Lnwd/Tg(Myh6-Tnnt2)117Lnwd
involves: C57BL/6 		perinatal lethality, complete penetrance J:48301
Tg(Myh6-Tnnt2)191Lnwd/0
involves: C57BL/6 		abnormal cardiac muscle relaxation J:48301
abnormal cardiovascular system physiology J:48301
abnormal heart atrium morphology J:48301
abnormal myocardial fiber morphology J:48301
abnormal myocardial fiber physiology J:48301
decreased cardiac muscle contractility J:48301
decreased heart weight J:48301
decreased myocardial fiber number J:48301
decreased myocardial fiber size J:48301
dilated heart atrium J:48301
disorganized myocardium J:48301
myocardial fiber degeneration J:48301
premature death J:48301
Tg(Myh6-Tnnt2*)1Feah/0
129S.FVB-Tg(Myh6-Tnnt2*)1Feah 		dilated cardiomyopathy J:137964
Tg(Myh6-Tnnt2*)1Feah/0
Tnnt2tm1Feah/Tnnt2+
involves: 129S/SvEv * 129S6/SvEvTac * FVB/N 		abnormal heart electrocardiography waveform feature J:137964
abnormal myocardial fiber physiology J:137964
congestive heart failure J:137964
decreased cardiac muscle contractility J:137964
dilated cardiomyopathy J:137964
dilated heart J:137964
increased heart rate J:137964
prolonged HV interval J:137964
prolonged QRS complex duration J:137964
prolonged QT interval J:137964
Tg(Myh6-Tnnt2*R92L)1Jcf/0
B6.Cg-Tg(Myh6-Tnnt2*R92L)1Jcf 		abnormal heart morphology J:104369
abnormal heart ventricle morphology J:104369
abnormal myocardial fiber morphology J:104369
cardiomyopathy J:104369
decreased cardiac muscle contractility J:104369
decreased cardiac muscle relaxation J:104369
decreased left ventricle systolic pressure J:104369
increased heart atrium size J:104369
myocardial fiber degeneration J:104369
Tg(Myh6-Tnnt2*R92Q)1Lnwd/0
involves: C57BL/6 		abnormal heart atrium morphology J:56911
abnormal heart ventricle morphology J:56911
abnormal sarcomere morphology J:56911
cardiac hypertrophy J:56911
decreased heart left ventricle size J:56911
Tg(Myh6-Tnnt2*R92Q)2Lnwd/0
involves: C57BL/6 		abnormal cardiac muscle contractility J:56911
abnormal cardiac muscle relaxation J:56911
abnormal heart atrium morphology J:56911
abnormal heart ventricle morphology J:56911
abnormal myocardial fiber morphology J:56911
abnormal myocardial fiber physiology J:56911
abnormal sarcomere morphology J:56911
cardiac hypertrophy J:56911
cardiac interstitial fibrosis J:56911
decreased heart left ventricle size J:56911
decreased myocardial fiber size J:56911
heart inflammation J:56911
increased cardiac muscle contractility J:56911
increased heart rate J:56911
myocardial fiber degeneration J:56911
perivascular fibrosis J:56911
Tg(Myh6-Tnnt2*R92Q)3Lnwd/0
involves: C57BL/6 		abnormal heart atrium morphology J:56911
abnormal heart ventricle morphology J:56911
abnormal myocardial fiber morphology J:56911
abnormal sarcomere morphology J:56911
cardiac hypertrophy J:56911
cardiac interstitial fibrosis J:56911
decreased heart left ventricle size J:56911
heart inflammation J:56911
myocardial fiber degeneration J:56911
myocardial fiber disarray J:56911
perivascular fibrosis J:56911
Tg(Myh6-Tnnt2*R92W)1Jcf/0
B6.Cg-Tg(Myh6-Tnnt2*R92W)1Jcf 		abnormal heart left ventricle morphology J:104369
abnormal heart morphology J:104369
abnormal myocardial fiber morphology J:104369
cardiomyopathy J:104369
decreased cardiac muscle contractility J:104369
decreased cardiac muscle relaxation J:104369
decreased heart weight J:104369
decreased left ventricle developed pressure J:104369
decreased left ventricle systolic pressure J:104369
decreased myocardial fiber size J:104369
dilated sarcoplasmic reticulum J:104369
myocardial fiber degeneration J:104369
small heart J:104369
Tnnt2tm1Feah/Tnnt2tm1Feah
involves: 129S6/SvEvTac * FVB/N 		abnormal heart development J:137964
abnormal myocardial fiber morphology J:137964
decreased cardiac muscle contractility J:137964
embryonic growth retardation J:137964
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:137964
embryonic lethality during organogenesis, complete penetrance J:137964
pericardial effusion J:137964
Tnnt2tm1Mmto/Tnnt2+
involves: 129S/SvEv 		no abnormal phenotype detected J:141967
Tnnt2tm1Mmto/Tnnt2tm1Mmto
involves: 129S/SvEv 		abnormal embryonic tissue morphology J:141967
abnormal sarcomere morphology J:141967
absent atrioventricular cushions J:141967
absent heartbeat J:141967
decreased embryo size J:141967
dilated heart J:141967
embryonic lethality during organogenesis, complete penetrance J:141967
failure of heart looping J:141967
Tnnt2tm2.1Feah/Tnnt2+
involves: 129S6/SvEvTac * FVB/N 		abnormal action potential J:243725
abnormal cardiovascular system physiology J:243725
abnormal heart echocardiography feature J:243725
abnormal myocardial fiber physiology J:243725
decreased cardiac muscle contractility J:243725
decreased heart rate J:243725
decreased survivor rate J:243725
dilated cardiomyopathy J:243725
dilated heart left ventricle J:243725
premature death J:243725
ventricular tachycardia J:243725
Tnnt2tm2Mmto/Tnnt2+
involves: 129S/SvEv * C57BL/6 		abnormal cardiovascular system physiology J:137784
abnormal heart left ventricle morphology J:137784
abnormal myocardial fiber physiology J:137784
cardiac interstitial fibrosis J:137784
decreased heart left ventricle muscle contractility J:137784
decreased left ventricle systolic pressure J:137784
enlarged heart J:137784
premature death J:137784
prolonged QT interval J:137784
Tnnt2tm2Mmto/Tnnt2tm2Mmto
involves: 129S/SvEv * C57BL/6 		abnormal cardiac muscle contractility J:137784
abnormal cardiovascular system physiology J:137784
abnormal heart left ventricle morphology J:137784
abnormal myocardial fiber physiology J:137784
cardiac interstitial fibrosis J:137784
decreased heart left ventricle muscle contractility J:137784
decreased left ventricle systolic pressure J:137784
enlarged heart J:137784
premature death J:137784
prolonged QT interval J:137784
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory