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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccr1
C-C motif chemokine receptor 1
MGI:104618
45 phenotypes from 2 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccr1tm1Cge/Ccr1tm1Cge
C.129S4-Ccr1tm1Cge 		decreased airway responsiveness J:95242
decreased CD4-positive, alpha-beta T cell number J:95242
decreased CD8-positive, alpha-beta T cell number J:95242
decreased interleukin-13 secretion J:95242
decreased susceptibility to Riboviria infection J:95242
Ccr1tm1Cge/Ccr1tm1Cge
involves: 129S4/SvJae 		abnormal renal glomerulus morphology J:115119
decreased tumor necrosis factor secretion J:43569
glomerular crescent J:115119
glomerulonephritis J:115119
glomerulosclerosis J:115119
normal immune system phenotype J:115119
impaired neutrophil recruitment J:43569
increased blood urea nitrogen level J:115119
increased IgG2a level J:115119
increased interferon-gamma secretion J:115119
increased susceptibility to type IV hypersensitivity reaction J:115119
increased tumor necrosis factor secretion J:115119
increased urine protein level J:115119
lung inflammation J:43569
Ccr1tm1Cge/Ccr1tm1Cge
involves: 129S4/SvJae * BALB/c 		abnormal chemokine secretion J:169909
abnormal circulating chemokine level J:169909
abnormal macrophage physiology J:169909
decreased circulating interferon-gamma level J:169909
decreased interleukin-10 secretion J:169909
decreased susceptibility to bacterial infection J:169909
decreased susceptibility to bacterial infection induced morbidity/mortality J:169909
decreased tumor necrosis factor secretion J:169909
increased interleukin-12 secretion J:169909
increased macrophage nitric oxide production J:169909
increased tumor necrosis factor secretion J:169909
Ccr1tm1Cge/Ccr1tm1Cge
involves: 129S4/SvJae * C57BL/6 		cecum inflammation J:107677
decreased susceptibility to bacterial infection J:107677
decreased susceptibility to experimental autoimmune encephalomyelitis J:63952
normal immune system phenotype J:63952
increased length of allograft survival J:59235
Ccr1tm1Gao/Ccr1tm1Gao
B6.129S4-Ccr1tm1Gao 		abnormal cellular extravasation J:104744
abnormal leukocyte adhesion J:104744
abnormal response to cardiac infarction J:104744
bronchiolitis J:162707
increased susceptibility to Coronaviridae infection J:162707
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:162707
Ccr1tm1Gao/Ccr1tm1Gao
involves: 129S4/SvJae 		abnormal Kupffer cell morphology J:152548
Ccr1tm1Gao/Ccr1tm1Gao
involves: 129S4/SvJae * C57BL/6 		abnormal neutrophil physiology J:41324
granulomatous inflammation J:41324
normal immune system phenotype J:41324
impaired hematopoiesis J:41324
increased susceptibility to fungal infection J:41324
increased susceptibility to parasitic infection J:41324
Ccr1tm1Gao/Ccr1tm1Gao
involves: C57BL/6 		decreased mast cell number J:94599
decreased susceptibility to type III hypersensitivity reaction J:94599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory