Dst Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dst
dystonin
MGI:104627

98 phenotypes from 27 alleles in 31 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dst^dt-23J/Dst^dt-23J Not Specified	axonal dystrophy	J:11718
Dst^dt-23Rbrc/Dst^dt-23Rbrc involves: C3H/HeN * C57BL/6	abnormal brainstem morphology	J:251779
	abnormal locomotor activation	J:251779
	abnormal muscle physiology	J:251779
	abnormal neuron morphology	J:251779
	abnormal posture	J:251779
	abnormal sensory neuron morphology	J:251779
	abnormal spinal cord morphology	J:251779
	abnormal spinal nerve morphology	J:251779
	axonal spheroids	J:251779
	decreased locomotor activity	J:251779
	decreased myelin sheath thickness	J:251779
	dystonia	J:251779
	impaired limb coordination	J:251779
	impaired righting response	J:251779
	muscular atrophy	J:251779
	neurodegeneration	J:251779
	premature death	J:251779
	slow postnatal weight gain	J:251779
Dst^dt-24J/Dst^dt-24J involves: C57BL/6	axonal dystrophy	J:11718
Dst^dt-27J/Dst⁺ B10.PL/(73NS)Sn-Dst^dt-27J/J	abnormal axon morphology	J:48174
	abnormal myelination	J:48174
	abnormal Schwann cell morphology	J:48174
Dst^dt-27J/Dst^dt-27J B10.PL/(73NS)Sn-Dst^dt-27J/J	abnormal axon morphology	J:48174, J:91505
	abnormal axonal transport	J:91505
	abnormal dorsal root ganglion morphology	J:91505
	abnormal dorsal spinal root morphology	J:47356, J:91495
	abnormal myelin sheath morphology	J:48174
	abnormal myelination	J:48174
	abnormal nervous system physiology	J:91505
	abnormal Schwann cell morphology	J:48174
	abnormal sciatic nerve morphology	J:91505
	abnormal sensory neuron morphology	J:47356
	abnormal somatic nervous system morphology	J:91505
	axon degeneration	J:91495, J:91505
	demyelination	J:48174, J:91495, J:91505
	peripheral nervous system degeneration	J:47356
Dst^dt-30J/Dst^dt-30J C57BL/6J-Dst^dt-30J/J	dystonia	J:155853
	neurodegeneration	J:155853
	premature death	J:155853
Dst^dt-31J/Dst^dt-31J involves: DBA/1LacJ	dystonia	J:155854
Dst^dt-31J/Dst^dt-31J involves: DBA/1LacJ	premature death	J:155854
Dst^dt-32J/Dst^dt-32J involves: 129S/Sv * 129S2/SvPas	abnormal somatic nervous system morphology	J:51014
	fecal incontinence	J:51014
	limb grasping	J:51014
	postnatal lethality	J:51014
	urinary incontinence	J:51014
Dst^dt-33J/Dst^dt-33J 129S1/Sv	ataxia	J:61053
	impaired coordination	J:61053
	postnatal lethality, complete penetrance	J:61053
	seizures	J:61053
Dst^dt-35J/Dst^dt-35J involves: 129S4/SvJae * C57BL/6	abnormal motor capabilities/coordination/movement	J:115254
Dst^dt-36J/Dst^dt-36J C57BL/6J-Dst^dt-36J/J	abnormal posture	J:82238
Dst^dt-37J/Dst^dt-37J C57BL/6J-Dst^dt-37J/J	axonal dystrophy	J:82238
	chromatolysis	J:82238
	decreased body size	J:82238
	decreased bone marrow cell number	J:82238
	decreased skeletal muscle fiber size	J:82238
	demyelination	J:82238
	dystonia	J:82238
	impaired righting response	J:82238
Dst^dt-38J/Dst^dt-38J involves: BALB/cByJ * C57BL/6J	abnormal posture	J:82238
	decreased body size	J:82238
	muscle spasm	J:82238
	normal reproductive system phenotype	J:82238
	weakness	J:82238
Dst^dt-39J/Dst^dt-39J involves: NOD	abnormal motor coordination/balance	J:157224
	cachexia	J:157224
	dystonia	J:157224
Dst^dt-alb/Dst^dt-alb BALB/cByJ-Dst^dt-alb	abnormal nervous system morphology	J:64441
	abnormal neuron morphology	J:6316
	dystonia	J:64441
Dst^dt-J/Dst^dt-J B6C3Fe a/a-Dst^dt-J/J	abnormal eye distance/ position	J:106403
	abnormal motor coordination/balance	J:106403
	abnormal postural reflex	J:106403
	abnormal posture	J:106403
	abnormal response to tactile stimuli	J:106403
	abnormal skin pigmentation	J:106403
	ataxia	J:106403
	decreased aggression	J:106403
	decreased body weight	J:106403
	decreased startle reflex	J:106403
	enophthalmos	J:106403
	impaired balance	J:106403
	impaired coordination	J:106403
	positive geotaxis	J:106403
	tremors	J:106403
Dst^dt-J/Dst^dt-J C3HeB/FeJ-Dst^dt-J	abnormal motor coordination/balance	J:24773
	abnormal posture	J:24773
	athetotic walking movements	J:24773
	postnatal lethality, complete penetrance	J:24773
Dst^dt/Dst^dt involves: C57BL/6 * Q	demyelination	J:6491
Dst^dt/Dst^dt involves: Q	dystonia	J:5674
	impaired limb coordination	J:5674
	limb grasping	J:5674
	neurodegeneration	J:5674
	premature death	J:5674
Dst^dt/Dst^dt Q-Dst^dt	abnormal nervous system morphology	J:5330
	axonal dystrophy	J:5330
	dystonia	J:64095
	gliosis	J:5330
	neurodegeneration	J:5330
	paresis	J:64095
	premature death	J:64095
Dst^em1Dcr/Dst^em1Dcr C57BL/6J-Dst^em1Dcr/Dcr	normal integument phenotype	J:352178
Dst^em3Dcr/Dst^em3Dcr C57BL/6J-Dst^em3Dcr/Dcr	normal integument phenotype	J:352178
Dst^em4Dcr/Dst^em4Dcr C57BL/6J-Dst^em4Dcr/Dcr	normal integument phenotype	J:352178
Dst^em5Dcr/Dst^em5Dcr C57BL/6J-Dst^em5Dcr/Dcr	normal integument phenotype	J:352178
Dst^{Gt(E182H05)Wrst}/Dst^{Gt(E182H05)Wrst} B6NCrj.129P2-Dst^{Gt(E182H05)Wrst}	abnormal brainstem morphology	J:251779
	abnormal neuron morphology	J:251779
	abnormal neuron physiology	J:228781
	abnormal posture	J:251779
	abnormal spinal cord morphology	J:251779
	abnormal trigeminal motor nucleus morphology	J:228781
	axon degeneration	J:228781
	axonal spheroids	J:251779
	decreased brain size	J:228781
	decreased myelin sheath thickness	J:228781
	demyelination	J:228781
	dystonia	J:228781, J:251779
	impaired limb coordination	J:228781
	neurodegeneration	J:228781, J:251779
	premature death	J:228781
	small dorsal root ganglion	J:228781
Dst^{Gt(E182H05)Wrst}/Dst^{Gt(E182H05)Wrst} involves: 129P2/OlaHsd * ICR	abnormal muscle electrophysiology	J:228781, J:251779
Dst^m1Btlr/Dst^m1Btlr C57BL/6J-Dst^m1Btlr	ataxia	J:218961
Dst^m1Btlr/Dst^m1Btlr C57BL/6J-Dst^m1Btlr	decreased body weight	J:218961
Dst^m2Btlr/Dst^m2Btlr C57BL/6J-Dst^m2Btlr	normal behavior/neurological phenotype	J:218962
	head tilt	J:218962
	stereotypic behavior	J:218962
Dst^m3Btlr/Dst^m3Btlr C57BL/6J-Dst^m3Btlr	ataxia	J:218968
Dst^m3Btlr/Dst^m3Btlr C57BL/6J-Dst^m3Btlr	impaired limb coordination	J:218968
Dst^Tg4/Dst⁺ involves: CD-1	abnormal axon morphology	J:48174
	abnormal myelination	J:48174
	abnormal Schwann cell morphology	J:48174
Dst^Tg4/Dst^Tg4 involves: C57BL/6 * CD-1	abnormal axon morphology	J:209161
	abnormal dorsal root ganglion morphology	J:209161
	abnormal gait	J:209161
	abnormal muscle spindle morphology	J:209161
	abnormal neuromuscular synapse morphology	J:209161
	abnormal sensory neuron morphology	J:209161
	axon degeneration	J:209161
	blepharoptosis	J:209161
	conjunctivitis	J:209161
	impaired coordination	J:209161
	limb grasping	J:209161
	neuron degeneration	J:209161
	postnatal lethality	J:209161
	slow postnatal weight gain	J:209161
	small dorsal root ganglion	J:209161
Dst^Tg4/Dst^Tg4 involves: CD-1	abnormal axon morphology	J:48174
	abnormal circumvallate papillae morphology	J:104592
	abnormal dorsal root ganglion morphology	J:91495
	abnormal dorsal spinal root morphology	J:17844, J:47356
	abnormal glossopharyngeal ganglion morphology	J:104592
	abnormal gustatory papilla taste bud morphology	J:104592
	abnormal muscle physiology	J:55704
	abnormal myelin sheath morphology	J:48174
	abnormal myelination	J:17844, J:48174
	abnormal nervous system physiology	J:48174
	abnormal Schwann cell morphology	J:48174
	abnormal sensory neuron morphology	J:47356
	abnormal skeletal muscle fiber mitochondrial morphology	J:55704
	abnormal skeletal muscle fiber morphology	J:55704
	abnormal vagus nerve morphology	J:104592
	abnormal Z line morphology	J:55704
	impaired limb coordination	J:17844
	impaired skeletal muscle contractility	J:55704
	muscle weakness	J:55704
	peripheral nervous system degeneration	J:47356
	postnatal lethality	J:17844
Dst^{tm1b(EUCOMM)Wtsi}/Dst⁺ C57BL/6N-Dst^{tm1b(EUCOMM)Wtsi}/Bay	abnormal embryo size	J:211773
	abnormal retina blood vessel morphology	J:211773
	persistence of hyaloid vascular system	J:211773
	unresponsive to tactile stimuli	J:211773
Dst^{tm1b(EUCOMM)Wtsi}/Dst^{tm1b(EUCOMM)Wtsi} C57BL/6N-Dst^{tm1b(EUCOMM)Wtsi}/Bay	preweaning lethality, incomplete penetrance	J:211773
	unresponsive to tactile stimuli	J:211773
Dst^tm1Efu/Dst^tm1Efu involves: C57BL/6	abnormal myelin sheath morphology	J:24974
	alopecia	J:24974
	axon degeneration	J:24974
	blistering	J:24974
	delayed wound healing	J:24974
	dystonia	J:24974
	impaired righting response	J:24974
	kinked tail	J:24974
	muscular atrophy	J:24974
	premature death	J:24974

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24