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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tle4
transducin-like enhancer of split 4
MGI:104633
49 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tle4em1(IMPC)Mbp/Tle4em1(IMPC)Mbp
C57BL/6NCrl-Tle4em1(IMPC)Mbp/Mmucd 		abnormal auditory brainstem response J:211773
abnormal cholesterol homeostasis J:211773
abnormal eye morphology J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
abnormal lymph node morphology J:211773
abnormal rectum morphology J:211773
abnormal skin morphology J:211773
decreased bone mineral content J:211773
decreased grip strength J:211773
decreased heart weight J:211773
decreased lean body mass J:211773
decreased locomotor activity J:211773
decreased prepulse inhibition J:211773
enlarged liver J:211773
enlarged lymph nodes J:211773
impaired glucose tolerance J:211773
increased total body fat amount J:211773
male infertility J:211773
small kidney J:211773
Tle4tm1.2Dasw/Tle4tm1.2Dasw
B6.129S6(Cg)-Tle4tm1.2Dasw 		abnormal hematopoietic stem cell physiology J:219243
abnormal long bone epiphyseal plate morphology J:219243
abnormal long bone epiphyseal plate proliferative zone J:219243
abnormal long bone hypertrophic chondrocyte zone J:219243
abnormal lymphopoiesis J:219243
abnormal thymus morphology J:219243
decreased B cell number J:219243
decreased body weight J:219243
decreased bone marrow cell number J:219243
decreased bone mineral content J:219243
decreased common myeloid progenitor cell number J:219243
decreased compact bone thickness J:219243
decreased DN2 thymocyte number J:219243
decreased double-positive T cell number J:219243
decreased follicular B cell number J:219243
decreased hematopoietic stem cell number J:219243
decreased leukocyte cell number J:219243
decreased long bone epiphyseal plate size J:219243
decreased lymphocyte cell number J:219243
decreased pre-pro B cell number J:219243
decreased spleen B cell follicle number J:219243
decreased trabecular bone mass J:219243
normal immune system phenotype J:219243
increased NK T cell number J:219243
increased thymocyte apoptosis J:219243
postnatal growth retardation J:219243
premature death J:219243
spleen hypoplasia J:219243
thymus atrophy J:219243
thymus hypoplasia J:219243
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory