Ptx3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptx3
pentraxin related gene
MGI:104641

17 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptx3^tm1Mant/Ptx3^tm1Mant either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal dendritic cell physiology	J:85080
	abnormal macrophage physiology	J:85080
	abnormal professional antigen presenting cell physiology	J:85080
	abnormal T-helper 1 physiology	J:85080
	impaired macrophage phagocytosis	J:85080
	increased susceptibility to bacterial infection	J:85080
	increased susceptibility to fungal infection	J:85080
	lung inflammation	J:85080
	reduced female fertility	J:85080
Ptx3^tm1Mant/Ptx3^tm1Mant involves: 129 * C57BL/6J	decreased litter size	J:91829
Ptx3^tm1Mant/Ptx3^tm1Mant involves: 129 * C57BL/6J	reduced female fertility	J:91829
Ptx3^tm1Mant/Ptx3^tm1Mant involves: 129S1/Sv * 129X1/SvJ	abnormal cumulus oophorus morphology	J:91829
	absent cumulus expansion	J:91829, J:126717
	female infertility	J:91829
	impaired fertilization	J:91829
	normal reproductive system phenotype	J:91829
Ptx3^tm1Zuk/Ptx3^tm1Zuk involves: 129S7/SvEvBrd	female infertility	J:76877
Ptx3^tm1Zuk/Ptx3^tm1Zuk involves: 129S7/SvEvBrd * C57BL/6J	abnormal cumulus oophorus morphology	J:76877
	absent cumulus expansion	J:76877
	decreased litter size	J:76877
	decreased superovulation rate	J:76877
	impaired fertilization	J:76877
	increased susceptibility to Coronaviridae infection	J:188421
	reduced female fertility	J:76877

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24