Ptx3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptx3
pentraxin related gene
MGI:104641

17 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptx3^tm1Mant/Ptx3^tm1Mant either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal dendritic cell physiology	J:85080
	abnormal macrophage physiology	J:85080
	abnormal professional antigen presenting cell physiology	J:85080
	abnormal T-helper 1 physiology	J:85080
	impaired macrophage phagocytosis	J:85080
	increased susceptibility to bacterial infection	J:85080
	increased susceptibility to fungal infection	J:85080
	lung inflammation	J:85080
	reduced female fertility	J:85080
Ptx3^tm1Mant/Ptx3^tm1Mant involves: 129 * C57BL/6J	decreased litter size	J:91829
Ptx3^tm1Mant/Ptx3^tm1Mant involves: 129 * C57BL/6J	reduced female fertility	J:91829
Ptx3^tm1Mant/Ptx3^tm1Mant involves: 129S1/Sv * 129X1/SvJ	abnormal cumulus oophorus morphology	J:91829
	absent cumulus expansion	J:91829, J:126717
	female infertility	J:91829
	impaired fertilization	J:91829
	normal reproductive system phenotype	J:91829
Ptx3^tm1Zuk/Ptx3^tm1Zuk involves: 129S7/SvEvBrd	female infertility	J:76877
Ptx3^tm1Zuk/Ptx3^tm1Zuk involves: 129S7/SvEvBrd * C57BL/6J	abnormal cumulus oophorus morphology	J:76877
	absent cumulus expansion	J:76877
	decreased litter size	J:76877
	decreased superovulation rate	J:76877
	impaired fertilization	J:76877
	increased susceptibility to Coronaviridae infection	J:188421
	reduced female fertility	J:76877

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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