Il15ra Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il15ra
interleukin 15 receptor, alpha chain
MGI:104644

21 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl B6.129X1-Il15ra^tm1.1Nsl	abnormal T cell activation	J:92705
	abnormal T cell proliferation	J:92705
	increased interleukin-2 secretion	J:92705
	increased T cell proliferation	J:92705
Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl involves: 129X1/SvJ * C57BL/6	abnormal T cell apoptosis	J:73738
	decreased CD8-positive, alpha-beta T cell number	J:73738
	decreased memory T cell number	J:73738
	decreased NK cell number	J:73738
	decreased NK T cell number	J:73738
	decreased single-positive T cell number	J:73738
	increased CD4-positive, alpha-beta T cell number	J:73738
	increased thymocyte apoptosis	J:73738
	lymph node hypoplasia	J:73738
Il15ra^tm1Ama/Il15ra^tm1Ama involves: 129X1/SvJ	abnormal NK cell physiology	J:119213
	decreased CD8-positive, alpha-beta T cell number	J:142570
	decreased CD8-positive, gamma-delta intraepithelial T cell number	J:155298
	decreased memory T cell number	J:142570
	decreased NK cell number	J:119213, J:142570
	decreased NK T cell number	J:142570
	decreased T cell proliferation	J:142570
	impaired natural killer cell mediated cytotoxicity	J:142570
Il15ra^tm1Ama/Il15ra^tm2.1Ama Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	abnormal immune system physiology	J:155298
	abnormal NK cell differentiation	J:155298
	abnormal NK cell physiology	J:155298
	decreased CD8-positive, alpha-beta T cell number	J:155298
	decreased memory T cell number	J:155298
	decreased NK cell number	J:155298
Il15ra^tm1Ama/Il15ra^tm2.1Ama Lyz2^tm1(cre)Ifo/0 Tg(Itgax-cre)1-1Reiz/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	abnormal immune system physiology	J:155298
	decreased CD8-positive, alpha-beta T cell number	J:155298
	decreased memory T cell number	J:155298
	decreased NK cell number	J:155298
Il15ra^tm1Ama/Il15ra^tm2.1Ama Tg(Itgax-cre)1-1Reiz/0 involves: 129X1/SvJ * C57BL/6J * CBA	abnormal NK cell differentiation	J:155298
	abnormal NK cell physiology	J:155298
	abnormal T cell subpopulation ratio	J:155298
	decreased CD8-positive, alpha-beta T cell number	J:155298
	decreased memory T cell number	J:155298
	decreased NK cell number	J:155298
Il15ra^tm1Ama/Il15ra^tm2.1Ama Tg(Vil1-cre)997Gum/0 involves: C57BL/6J * SJL	decreased CD8-positive, gamma-delta intraepithelial T cell number	J:155298
Il15ra^tm1Nsl/Il15ra^tm1Nsl involves: 129X1/SvJ	no abnormal phenotype detected	J:73738

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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