Atoh1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Atoh1
atonal bHLH transcription factor 1
MGI:104654

30 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Atoh1^tm1(cre)Gan/Atoh1^tm1(cre)Gan involves: 129S6/SvEvTac * C57BL/6	neonatal lethality, complete penetrance	J:160667
Atoh1^{tm1(cre/ERT2)Mhos}/Atoh1^{tm1(cre/ERT2)Mhos} Not Specified	abnormal cochlear VIII nucleus morphology	J:149533
	abnormal glutaminergic neuron morphology	J:149533
Atoh1^tm1Hzo/Atoh1^tm1Hzo involves: 129S7/SvEvBrd	abnormal cerebellar Purkinje cell layer	J:44241
	abnormal cerebellum external granule cell layer morphology	J:44241
	absent cerebellar foliation	J:44241
	cyanosis	J:44241
	neonatal lethality, complete penetrance	J:44241
	respiratory failure	J:44241
	small cerebellum	J:44241
Atoh1^tm2Hzo/Atoh1^tm2Hzo Not Specified	abnormal cerebellar Purkinje cell layer	J:60393
	abnormal cerebellum external granule cell layer morphology	J:60393
	abnormal hindbrain development	J:105186
	absent cerebellar foliation	J:60393
	absent cochlear hair cells	J:55694
	absent vestibular hair cells	J:55694
	cyanosis	J:60393
	decreased pulmonary respiratory rate	J:155760
	neonatal lethality, complete penetrance	J:60393, J:155760
	normal nervous system phenotype	J:60393
	respiratory failure	J:60393
	small cerebellum	J:60393
Atoh1^tm2Hzo/Atoh1^tm3.1Hzo involves: 129S7/SvEvBrd * C57BL/6J * FVB/N * SJL	neonatal lethality, complete penetrance	J:128312
Atoh1^tm2Hzo/Atoh1^tm3Hzo Tg(Fabp1-cre)1Jig/0 involves: 129S7/SvEvBrd * C57BL/6J * FVB/N * SJL	abnormal small intestine crypts of Lieberkuhn morphology	J:128312
	impaired intestine regeneration	J:128312
	normal mortality/aging	J:128312
Atoh1^tm2Hzo/Atoh1^tm3Hzo Tg(Vil1-cre)997Gum/0 involves: 129S7/SvEvBrd * C57BL/6J * SJL	postnatal lethality, complete penetrance	J:128312
Atoh1^tm3Hzo/Atoh1^tm1Hzo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ involves: 129 * 129S7/SvEvBrd	thin external granule cell layer	J:155047
Atoh1^tm3Hzo/Atoh1^tm3Hzo involves: 129S7/SvEvBrd	decreased neuronal precursor proliferation	J:155047
Atoh1^trhl/Atoh1^trhl B6.Cg-Atoh1^trhl	abnormal cerebellum external granule cell layer morphology	J:209662
	abnormal distortion product otoacoustic emission	J:209662
	abnormal gait	J:209662
	abnormal pinna reflex	J:209662
	absent cerebellar foliation	J:209662
	cochlear inner hair cell degeneration	J:209662
	cochlear outer hair cell degeneration	J:209662
	deafness	J:209662
	decreased inner hair cell stereocilia number	J:209662
	decreased outer hair cell stereocilia number	J:209662
	impaired hearing	J:209662
	increased or absent threshold for auditory brainstem response	J:209662
	normal mortality/aging	J:209662
	small cerebellum	J:209662

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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