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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dll1
delta like canonical Notch ligand 1
MGI:104659
91 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dll1m1Mhda/Dll1+
C3HeB/FeJ-Dll1m1Mhda 		decreased body height J:150183
decreased body weight J:150183
decreased bone mineral content J:150183
decreased bone mineral density J:150183
decreased circulating cholesterol level J:150183
decreased circulating triglyceride level J:150183
decreased heart rate J:150183
decreased total body fat amount J:150183
hyperactivity J:150183
normal immune system phenotype J:150183
increased basal metabolism J:150183
increased blood uric acid level J:150183
increased lean body mass J:150183
increased mean systemic arterial blood pressure J:150183
increased systemic arterial diastolic blood pressure J:150183
increased systemic arterial systolic blood pressure J:150183
premature death J:150183
Dll1m1Mhda/Dll1m1Mhda
C3HeB/FeJ-Dll1m1Mhda 		decreased body weight J:150183
preweaning lethality, incomplete penetrance J:150183
Dll1m594592Hubr/Dll1m594592Hubr
involves: C57BL/6 * FVB/N 		abnormal direction of heart looping J:173681
abnormal heart morphology J:173681
abnormal neural tube morphology J:173681
abnormal somite shape J:173681
caudal body truncation J:166883, J:173681
short tail J:173681
situs inversus J:166883, J:173681
Dll1tm1.1(cre/ERT2)Cle/Dll1+
Not Specified 		no abnormal phenotype detected J:193937
Dll1tm1.1Hri/Dll1tm1.1Hri
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal pancreas development J:184814
Dll1tm1.1Mjo/Dll1+
Not Specified 		abnormal vertebrae morphology J:186213
Dll1tm1Gos/Dll1+
C3Fe.129-Dll1tm1Gos 		abnormal defecation J:150183
abnormal enzyme/coenzyme activity J:150183
abnormal Q wave J:150183
decreased B-1 B cell number J:150183
decreased basal metabolism J:150183
decreased blood uric acid level J:150183
decreased body height J:150183
decreased body weight J:150183
decreased bone mineral content J:150183
decreased bone mineral density J:150183
decreased CD4-positive, alpha-beta T cell number J:150183
decreased CD8-positive, alpha-beta T cell number J:150183
decreased circulating cholesterol level J:150183
decreased circulating total protein level J:150183
decreased circulating triglyceride level J:150183
decreased food intake J:150183
decreased heart rate J:150183
decreased IgA level J:150183
decreased IgG1 level J:150183
decreased IgG2b level J:150183
decreased IgG3 level J:150183
decreased lean body mass J:150183
decreased locomotor activity J:150183
decreased lumbar vertebrae number J:150183
decreased total body fat amount J:150183
increased B cell number J:150183
increased basal metabolism J:150183
increased bone mineral density J:150183
increased CD8-positive, alpha-beta T cell number J:150183
increased mean systemic arterial blood pressure J:150183
increased susceptibility to weight loss J:150183
increased systemic arterial diastolic blood pressure J:150183
increased systemic arterial systolic blood pressure J:150183
Dll1tm1Gos/Dll1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone mineral density J:150183
decreased CD4-positive, alpha-beta T cell number J:150183
increased B cell number J:150183
increased basal metabolism J:150183
increased susceptibility to weight loss J:150183
Dll1tm1Gos/Dll1tm1Gos
involves: 129S1/Sv * 129X1/SvJ 		abnormal neuron differentiation J:156172
decreased neuronal precursor cell number J:156172
embryonic lethality during organogenesis, complete penetrance J:156172
increased motor neuron number J:156172
increased neuron number J:156172
Dll1tm1Gos/Dll1tm1Gos
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal brain development J:39633
abnormal direction of embryo turning J:80018
abnormal direction of heart looping J:80018
abnormal neuron differentiation J:39633
abnormal notochord morphology J:80018
abnormal pancreas development J:57072
abnormal paraxial mesoderm morphology J:39633
abnormal primitive node morphology J:80018
abnormal somatic nervous system morphology J:39633
abnormal somite border morphology J:39633
abnormal somite development J:39633
abnormal somite shape J:39633
abnormal spinal nerve morphology J:39633
absent embryonic cilia J:80018
embryonic lethality during organogenesis, complete penetrance J:39633
enlarged floor plate J:80018
fused dorsal root ganglion J:39633
hemorrhage J:39633
incomplete somite formation J:39633
Dll1tm1Gos/Dll1tm2Gos
involves: 129S1/Sv * 129X1/SvJ 		abnormal capillary branching pattern J:148902
abnormal muscle morphology J:148902
abnormal myogenesis J:148902
abnormal skin vasculature morphology J:148902
aorta stenosis J:148902
artery stenosis J:148902
decreased skeletal muscle mass J:148902
perinatal lethality J:148902
Dll1tm1Gos/Dll1tm2Gos
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal axial skeleton morphology J:119082
abnormal myoblast differentiation J:119082
abnormal myotube differentiation J:119082
abnormal somite development J:132241
decreased body length J:119082
decreased skeletal muscle mass J:119082
no spontaneous movement J:119082
perinatal lethality, complete penetrance J:119082
Dll1tm1Mjo/Dll1tm1Mjo
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cochlear hair cell morphology J:107414
abnormal utricular macula morphology J:107414
abnormal vestibular saccular macula morphology J:107414
decreased cochlea coiling J:107414
increased cochlear inner hair cell number J:107414
increased cochlear outer hair cell number J:107414
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129 		abnormal capillary branching pattern J:148902
abnormal skin vasculature morphology J:148902
aorta stenosis J:148902
artery stenosis J:148902
Dll1tm1Mjo/Dll1tm1Mjo
Tg(KRT5-cre)1Tak/?
Tg(Mx1-cre)1Cgn/?
involves: 129 * C3H * C57BL/6 * CBA 		normal immune system phenotype J:90630
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Mx1-cre)1Cgn/?
involves: 129 * C57BL/6 * CBA 		absent marginal zone B cells J:90630
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Six2-EGFP/cre)1Amc/0
involves: 129 * C57BL/6 * CD-1 		abnormal nephron morphogenesis J:198632
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12/10/2024
MGI 6.24 		The Jackson Laboratory