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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rora
RAR-related orphan receptor alpha
MGI:104661
107 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rorasg-3J/Rorasg-3J
C57BL/6J-Rorasg-3J/J 		abnormal cerebellar Purkinje cell layer J:87349
decreased body size J:87349
impaired balance J:87349
impaired limb coordination J:87349
impaired righting response J:87349
Rorasg/Rora+
involves: C57BL 		abnormal cerebellar granule layer morphology J:1431
abnormal cerebellar layer morphology J:1431
abnormal cerebellum morphology J:1431
abnormal inferior olivary complex morphology J:1431
decreased cerebellar granule cell number J:1431
decreased Purkinje cell number J:1431
small cerebellum J:1431
Rorasg/Rora+
involves: C57BL/6J 		abnormal spatial learning J:30686
Rorasg/Rorasg
involves: C57BL 		abnormal cerebellar granule cell morphology J:5968
abnormal cerebellar granule layer morphology J:5968
abnormal cerebellar layer morphology J:5968
abnormal cerebellar Purkinje cell layer J:5968
abnormal cerebellum deep nucleus morphology J:6554
abnormal cerebellum morphology J:6088
abnormal Purkinje cell dendrite morphology J:5968
abnormal Purkinje cell differentiation J:5968
abnormal Purkinje cell morphology J:6185, J:6260
abnormal synaptic glutamate release J:6875
decreased aspartic acid level J:6875
decreased gamma-aminobutyric acid level J:6875
decreased Purkinje cell size J:5968
decreased taurine level J:6875
delaminated Purkinje cell layer J:5968
increased noradrenaline level J:164122
small cerebellum J:6875
thin cerebellar granule layer J:5968
thin cerebellar molecular layer J:5968
Rorasg/Rorasg
involves: C57BL/6 		abnormal cerebellum morphology J:6930
abnormal estrous cycle J:1960
abnormal external female genitalia morphology J:1960
abnormal female reproductive system physiology J:1960
abnormal fertility/fecundity J:14535
abnormal immune system organ morphology J:2228
abnormal immune system physiology J:2228
abnormal inferior olivary complex morphology J:20982, J:28468
abnormal lipid homeostasis J:52105
abnormal lung compliance J:135863
abnormal macrophage physiology J:28095
abnormal maternal nurturing J:14497
abnormal olfaction J:39053, J:107925
abnormal respiratory mucosa morphology J:135863
abnormal sexual interaction J:14535, J:26698
abnormal spatial learning J:30012
abnormal vasoconstriction J:109735
abnormal vasodilation J:109735
atherosclerotic lesions J:52105
decreased circulating cholesterol level J:52105
decreased circulating HDL cholesterol level J:52105
decreased mean systemic arterial blood pressure J:109735
delayed estrous cycle J:1960
normal immune system phenotype J:52105
increased angiogenesis J:115425
increased IgE level J:135863
increased interleukin-1 secretion J:28095
increased susceptibility to atherosclerosis J:52105
lung inflammation J:135863
prolonged estrus J:1960
prolonged metestrus J:1960
reduced female fertility J:1960
spleen atrophy J:2228
normal taste/olfaction phenotype J:15645
thymus atrophy J:2228
Rorasg/Rorasg
involves: obese stock 		abnormal brain morphology J:13140
abnormal cerebellar foliation J:13140
abnormal cerebellar granule cell morphology J:5304
abnormal cerebellar granule layer morphology J:13140
abnormal cerebellar layer morphology J:5304
abnormal cerebellar molecular layer J:13140
abnormal cerebellum morphology J:6068, J:13140
abnormal cochlear VIII nucleus morphology J:121314
abnormal gait J:13140
abnormal hormone level J:28467
abnormal limb posture J:13140
abnormal motor capabilities/coordination/movement J:13140
abnormal motor learning J:46854
abnormal nervous system physiology J:28478
abnormal olfactory bulb external plexiform layer morphology J:55239
abnormal olfactory bulb glomerular layer morphology J:55239
abnormal olfactory bulb granule cell layer morphology J:55239
abnormal olfactory bulb granule cell morphology J:55239
abnormal olfactory bulb internal plexiform layer morphology J:55239
abnormal olfactory bulb layer morphology J:55239
abnormal olfactory bulb mitral cell layer morphology J:55239
abnormal olfactory bulb morphology J:55239
abnormal olfactory bulb outer nerve layer morphology J:55239
abnormal Purkinje cell morphology J:121314
ataxia J:13140, J:18435
decreased body size J:13140
decreased cerebellar granule cell number J:5304
decreased grip strength J:46854
decreased locomotor activity J:13140
impaired coordination J:13140, J:46854
limb grasping J:46854
postnatal lethality, incomplete penetrance J:13140
small cerebellum J:5304, J:13140
small olfactory bulb J:55239
thin cerebellar molecular layer J:13140
tremors J:13140
Roratm1b(EUCOMM)Wtsi/Rora+
C57BL/6N-Roratm1b(EUCOMM)Wtsi/Ieg 		decreased startle reflex J:211773
increased circulating alkaline phosphatase level J:211773
Roratm1b(EUCOMM)Wtsi/Roratm1b(EUCOMM)Wtsi
C57BL/6N-Roratm1b(EUCOMM)Wtsi/Ieg 		preweaning lethality, incomplete penetrance J:211773
Roratm1Mba/Roratm1Mba
involves: 129P2/OlaHsd * C57BL/6 		abnormal cerebellar Purkinje cell layer J:46854
abnormal excitatory postsynaptic currents J:46854
abnormal motor learning J:46854
abnormal Purkinje cell dendrite morphology J:46854
absent cerebellar granule cells J:46854
absent duvet hair J:46854
ataxia J:46854
decreased grip strength J:46854
decreased Purkinje cell number J:46854
ectopic Purkinje cell J:46854
impaired coordination J:46854
lethality at weaning, incomplete penetrance J:46854
limb grasping J:46854
Purkinje cell degeneration J:46854
retarded hair growth J:46854
small cerebellum J:46854
sparse hair J:46854
thin cerebellar granule layer J:46854
Roratm1Vgi/Roratm1Vgi
involves: 129S1/Sv * 129X1/SvJ * ICR 		decreased Purkinje cell number J:46140
ectopic Purkinje cell J:46140
impaired balance J:46140
postnatal lethality, complete penetrance J:46140
small cerebellum J:46140
tremors J:46140
Roratmgc26/Roratmgc26
involves: D7R75M 		abnormal brain interneuron morphology J:171777
abnormal cerebellar granule layer morphology J:171777
abnormal cerebellar molecular layer J:171777
abnormal cerebellum external granule cell layer morphology J:171777
abnormal cerebellum morphology J:81149
abnormal neuron proliferation J:171777
abnormal Purkinje cell morphology J:171777
abnormal radial glial cell morphology J:171777
absent cerebellar granule layer J:81149
ataxia J:81149, J:171777
decreased cerebellar granule cell number J:171777
decreased cerebellar granule cell precursor proliferation J:171777
decreased Purkinje cell size J:171777
ectopic cerebellar granule cells J:171777
ectopic Purkinje cell J:171777
hindlimb paralysis J:81149, J:171777
postnatal lethality, incomplete penetrance J:81149, J:171777
reduced cerebellar foliation J:171777
small cerebellum J:171777
thin cerebellar molecular layer J:171777
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory