Pml Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pml
promyelocytic leukemia
MGI:104662

17 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pml^tm1.1Ews/Pml^tm1.1Ews FVB.129P2-Pml^tm1.1Ews	abnormal double-strand DNA break repair	J:262172
	abnormal PML bodies	J:262172
	elevated level of mitotic sister chromatid exchange	J:262172
	increased cellular sensitivity to ionizing radiation	J:262172
	increased hematopoietic stem cell number	J:262172
	normal neoplasm	J:262172
Pml^tm1.1Ews/Pml^tm1.1Ews involves: 129 * 129P2/OlaHsd	increased B cell derived lymphoma incidence	J:262172
Pml^tm1.1Ews/Pml^tm1.1Ews involves: 129 * 129P2/OlaHsd	increased T cell derived lymphoma incidence	J:262172
Pml^tm1Ppp/Pml^tm1Ppp FVB.129S7-Pml^tm1Ppp	abnormal double-strand DNA break repair	J:262172
Pml^tm1Ppp/Pml^tm1Ppp FVB.129S7-Pml^tm1Ppp	increased hematopoietic stem cell number	J:262172
Pml^tm1Ppp/Pml^tm1Ppp involves: 129S7/SvEvBrd	abnormal cell physiology	J:46381
	abnormal immune system cell morphology	J:46381
	abnormal myelopoiesis	J:46381
	decreased granulocyte number	J:46381
	decreased leukocyte cell number	J:46381
	increased fibroblast proliferation	J:46381
	increased lymphoma incidence	J:46381
	increased susceptibility to bacterial infection	J:46381
	increased tumor incidence	J:46381

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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